Relation Results

Summary

Name FGF6
Full Name Fibroblast growth factor 6
Synonyms FGF-6, Heparin secretory-transforming protein 2, HST-2, HSTF-2, Heparin-binding growth factor 6, HBGF-6 | HST2, HSTF2
Primary ID P10767
Links - -
Type protein
Relations 2
Function Plays an important role in the regulation of cell proliferation, cell differentiation, angiogenesis and myogenesis, and is required for normal muscle ...
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Type: Score: Layout: SPV 
0.7470.726FGF6FGFR2FGFR4

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Relations
Regulator
Mechanism
target
score ℹ
+ FGF6up-regulates img/direct-activation.png binding FGFR2 0.747
Identifier Residue Sequence Organism Cell Line
SIGNOR-42380 Homo sapiens
pmid sentence
The nine known fgf ligands and the four signaling fgf receptors (and their alternatively spliced variants) are expressed in specific spatial and temporal patterns. The activity of this signaling pathway is regulated by ligand binding specificity, heparan sulfate proteoglycans, and the differential signaling capacity of individual fgf receptors.
Publications: 1 Organism: Homo Sapiens
+ FGF6up-regulates img/direct-activation.png binding FGFR4 0.726
Identifier Residue Sequence Organism Cell Line
SIGNOR-18570 Homo sapiens
pmid sentence
Our results establish an fgf binding profile for fgfr-4 with afgf having the highest affinity, followed by k-fgf/hst-1 and bfgf. In addition, fgf-6 was found to bind to fgfr-4 in ligand competition experiments. Ligands binding to fgfr-4 induced receptor autophosphorylation and phosphorylation of a set of cellular polypeptides.
Publications: 1 Organism: Homo Sapiens
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