Summary

Name FGFR4
Full Name Fibroblast growth factor receptor 4
Synonyms FGFR-4 | JTK2, TKF
Primary ID P22455
Links - -
Type protein
Relations 16
Pathways Rhabdomyosarcoma
Inhibitors BGJ-398; nintedanib; ponatinib
Function Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation. FGFR4 signaling is down-regulated by receptor internalization and degradation; MMP14 promotes internalization and degradation of FGFR4. Mutations that lead to constitutive kinase activation or impair normal FGFR4 inactivation lead to aberrant signaling.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation FGFR4 0.2
Publications: 2 Organism: Homo Sapiens
Pathways:Rhabdomyosarcoma
+ up-regulates activity img/direct-activation.png phosphorylation STAT1 0.355
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation STAT3 0.414
Publications: 1 Organism: Homo Sapiens
Pathways:Rhabdomyosarcoma
+ up-regulates activity img/direct-activation.png phosphorylation FGFR4 0.2
Publications: 1 Organism: In Vitro
Pathways:Rhabdomyosarcoma
+ up-regulates img/direct-activation.png binding FGFR4 0.657
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition FGFR4 0.8
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition FGFR4 0.8
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation FRS2 0.671
Publications: 1 Organism: Rattus Norvegicus
+ up-regulates img/direct-activation.png binding FGFR4 0.72
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation FGFR4 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding FGFR4 0.81
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation FGFR4 0.378
Publications: 1 Organism: Homo Sapiens
Pathways:Rhabdomyosarcoma
+ up-regulates img/direct-activation.png binding FGFR4 0.819
Publications: 1 Organism: Homo Sapiens
Pathways:Rhabdomyosarcoma
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation FGFR4 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition FGFR4 0.8
Publications: 1 Organism: Homo Sapiens