Summary

Name MCF2
Full Name Proto-oncogene DBL
Synonyms Proto-oncogene MCF-2 | DBL
Primary ID P10911
Links - -
Type protein
Relations 3
Function Guanine nucleotide exchange factor (GEF) that modulates the Rho family of GTPases. Promotes the conversion of some member of the Rho family GTPase from the GDP-bound to the GTP-bound form. Isoform 1 exhibits no activity toward RHOA, RAC1 or CDC42. Isoform 2 exhibits decreased GEF activity toward CDC42. Isoform 3 exhibits a weak but significant activity toward RAC1 and CDC42. Isoform 4 exhibits significant activity toward RHOA and CDC42. The truncated DBL oncogene is active toward RHOA, RAC1 and CDC42.

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Relations

Regulator Mechanism target score ℹ
+ MCF2up-regulates activity img/direct-activation.png guanine nucleotide exchange factor CDC42 0.769
Publications: 1 Organism: Homo Sapiens
+ MCF2up-regulates activity img/direct-activation.png guanine nucleotide exchange factor RHOA 0.743
Publications: 1 Organism: Homo Sapiens
+ MCF2up-regulates activity img/direct-activation.png guanine nucleotide exchange factor RAC1 0.651
Publications: 1 Organism: Homo Sapiens