3.0
Summary
| Name |  RALAView Modifications |
| Full Name | Ras-related protein Ral-A |
| Synonyms | RALA_HUMAN | RAL |
| Primary ID | P11233 |
| Links |  -  -  |
| Type | protein |
| Relations | 8 |
| Function | Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. The RALA-exocyst complex regulates integrin-dependent membrane raft exocytosis and growth signaling (PubMed:20005108). Key regulator of LPAR1 signaling and competes with GRK2 for binding to LPAR1 thus affecting the signaling properties of the receptor. Required for anchorage-independent proliferation of transformed cells (PubMed:19306925). During mitosis, supports the stabilization and elongation of the intracellular bridge between dividing cells. Cooperates with EXOC2 to recruit other components of the exocyst to the early midbody (PubMed:18756269). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PPP2CB | down-regulates 
dephosphorylation
|
RALA | 0.293 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | RALA | up-regulates activity 
phosphorylation
|
FOXO4 | 0.2 |
| Publications: | 2 | Organism: | Mus Musculus | |
| + | RALA | up-regulates activity
phosphorylation
|
FOXO | 0.2 |
| Publications: | 2 | Organism: | Mus Musculus | |
| + | RalGAP2 | down-regulates activity
guanine nucleotide exchange factor
|
RALA | 0.497 |
| Publications: | 1 | Organism: | Mus Musculus | |
| + | RalGAP1 | down-regulates activity
guanine nucleotide exchange factor
|
RALA | 0.43 |
| Publications: | 1 | Organism: | Mus Musculus | |