Relation Results

Summary

Name SLC25A4
Full Name ADP/ATP translocase 1
Synonyms ADP,ATP carrier protein 1, ADP,ATP carrier protein, heart/skeletal muscle isoform T1, Adenine nucleotide translocator 1, ANT 1, Solute carrier family 25 member 4 | ANT1
Primary ID P12235
Links - -
Type protein
Relations 2
Function ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell (PubMed:2158665 ...
View More

Viewer

Type: Score: Layout: SPV 
0.2780.272TSPO2SLC25A4PTPN11

Search Tools

Refine search:

  • by mechanism


  • by effect
  • by organism:


  • by tissue:


  • by cell-line

Relations
Regulator
Mechanism
target
score ℹ
+ TSPO2up-regulates activity img/direct-activation.png binding SLC25A4 0.278
Identifier Residue Sequence Organism Cell Line
SIGNOR-261825 Homo sapiens Erythrocyte
pmid sentence
Our results demonstrate the existence of a VDAC-TSPO2-ANT complex that mediates ATP release from RBCs. We previously demonstrated that the translocase protein TSPO2 together with the voltage-dependent anion channel (VDAC) and adenine nucleotide transporter (ANT) were involved in a membrane transport complex in human red blood cells (RBCs). . The present results show that TSPO ligands induce polymerization of VDAC, coupled to activation of ATP release by a supramolecular complex involving VDAC, TSPO2 and ANT.
Publications: 1 Organism: Homo Sapiens
+ PTPN11down-regulates activity img/direct_inhibition.png dephosphorylation SLC25A4 0.272
Identifier Residue Sequence Organism Cell Line
SIGNOR-277124 Homo sapiens
pmid sentence
Specifically, SHP2-mediated dephosphorylation of ANT1 at Tyr 191 is essential for mitochondrial homeostasis and mitigation of NLRP3 inflammasome activation.|The interaction between SHP2 and ANT1 (Fig.\u00a0 xref ), and the opposite effects of SHP2 and ANT1 shRNAs in the activation of NLRP3 inflammasome (Figs.\u00a0 xref and xref ) raised the possibility that the SHP2 may inhibit ANT1 to suppress NLRP3 inflammasome activation.|To further determine which tyrosine phosphorylation site of ANT1 is dephosphorylated by SHP2, we created the dephosphorylated mutant of ANT1, in which tyrosine was replaced with phenylalanine (Y to F mutation).
Publications: 1 Organism: Homo Sapiens
a simple tooltip