| + |
Immune complexes | up-regulates activity 
|
FCGR1A |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249521 |
|
|
Homo sapiens |
Macrophage |
| pmid |
sentence |
| 18064051 |
Immune complexes bind to activating Fc receptors (FcR) and inhibitory FcRs that are expressed by innate immune effector cells such as basophils, mast cells, neutrophils, monocytes and macrophages, in which they trigger the indicated effector responses. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SPI1 | up-regulates quantity by expression
transcriptional regulation
|
FCGR1A |
0.539 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255697 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12393465 |
In patients with t(8;21), expression of the cell surface markers CD11b, CD14, and CD64 was less in comparison to patients without t(8;21) (Figure 5B). CD14 and CD64 promoters have putative PU.1 binding sites but not AML1-, C/EBPα-, or MEF-binding sites suggesting that down-regulation of the function of PU.1 by AML1-ETO could possibly be an important step in progression toward leukemia. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FCGR1A | up-regulates
|
M2_polarization |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249524 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24445665 |
Although crosslinking of activating FcgammaRs on monocytes and macrophages induces the production of several pro-inflammatory cytokines and chemokines, immune complex-mediated signalling via activating FcgammaRs together with Toll-like receptor (TLR) triggering induces a specific M2 activation state in macrophages macrophages in this state were termed M2b or regulatory macrophages. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
porfimer | down-regulates activity 
chemical inhibition
|
FCGR1A |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259303 |
|
|
Homo sapiens |
Monocyte |
| pmid |
sentence |
| 2544592 |
Inhibition of the high affinity Fc receptor (Fc gamma RI) on human monocytes by porphyrin photosensitization is highly specific and mediated by the generation of superoxide radicals. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
FCGR1A
- 
- 