3.0
Summary
| Name |  XRCC6View Modifications |
| Full Name | X-ray repair cross-complementing protein 6 |
| Synonyms | 5'-deoxyribose-5-phosphate lyase Ku70, 5'-dRP lyase Ku70, 70 kDa subunit of Ku antigen, ATP-dependent DNA helicase 2 subunit 1, ATP-dependent DNA helicase II 70 kDa subunit, CTC box-binding factor 75 kDa subunit, CTC75, CTCBF, DNA repair protein XRCC6, Lupus Ku autoantigen protein p70, Ku70, Thyroid-lupus autoantigen, TLAA, X-ray repair complementing defective repair in Chinese hamster cells 6 | G22P1 |
| Primary ID | P12956 |
| Links |  -  -  |
| Type | protein |
| Relations | 7 |
| Function | Single-stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold. The XRCC5/6 dimer is probably involved in stabilizing broken DNA ends and bringing them together. The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step. Required for osteocalcin gene expression. Probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks. 5'-dRP lyase activity allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined. The XRCC5/6 dimer together with APEX1 acts as a negative regulator of transcription. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | PRKDC | up-regulates activity 
phosphorylation
|
XRCC6 | 0.939 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | ATM | up-regulates activity
phosphorylation
|
XRCC6 | 0.703 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | XRCC6 | up-regulates activity
relocalization
|
UBE2S | 0.353 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | XRCC6 | up-regulates
relocalization
|
PRKDC | 0.939 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | XRCC6 | form complex 
binding
|
DNA-PK | 0.963 |
| Publications: | 1 | Organism: | Homo Sapiens | |