| + |
IL7 | up-regulates 
binding
|
IL7R |
0.912 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-37012 |
|
|
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 8204885 |
Antibody r34.34 was further found to be directed against an epitope interfering with binding of interleukin-7 (il-7) to pre-alp cells. Expression cloning from a pre-alp cdna library showed that r34.34 antigen is cdw127, the 75- to 80-kd il-7 receptor. Proliferation of the b-lineage all cell lines reh and mieliki was inhibited by il-7, and this effect was specifically reverted by moab r34.34. In addition, antibody r34.34 specifically inhibited il-7-dependent proliferation of normal bcp, pre-alp cells, and peripheral t cells. These results imply that both inhibitory and proliferative effects of il-7 can be mediated through the same receptor on various lineages. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-163548 |
|
|
Homo sapiens |
Satellite Cell |
| pmid |
sentence |
| 20089933 |
This receptor (il-7r) is a heterodimer consisting of the il-7r chain and the common cytokine ? -chain. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle, Skeletal Muscle, Myotube |
| + |
IL7 | up-regulates
binding
|
IL2RG |
0.698 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-163545 |
|
|
Homo sapiens |
Satellite Cell |
| pmid |
sentence |
| 20089933 |
This receptor (il-7r) is a heterodimer consisting of the il-7r chain and the common cytokine ? -chain. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-108864 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11418623 |
The common gamma-chain (gamma(c)) is an indispensable subunit of the functional receptor complexes for il-4, il-7, il-9, il-15, il-2, il21 |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle, Skeletal Muscle, Myotube |
3.0
IL7
- 
- 