| + |
IL7 | up-regulates 
binding
|
IL7R |
0.912 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-163548 |
|
|
Homo sapiens |
Satellite Cell |
| pmid |
sentence |
| 20089933 |
This receptor (il-7r) is a heterodimer consisting of the il-7r chain and the common cytokine ? -chain. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-37012 |
|
|
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 8204885 |
Antibody r34.34 was further found to be directed against an epitope interfering with binding of interleukin-7 (il-7) to pre-alp cells. Expression cloning from a pre-alp cdna library showed that r34.34 antigen is cdw127, the 75- to 80-kd il-7 receptor. Proliferation of the b-lineage all cell lines reh and mieliki was inhibited by il-7, and this effect was specifically reverted by moab r34.34. In addition, antibody r34.34 specifically inhibited il-7-dependent proliferation of normal bcp, pre-alp cells, and peripheral t cells. These results imply that both inhibitory and proliferative effects of il-7 can be mediated through the same receptor on various lineages. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle, Skeletal Muscle, Myotube |
| + |
NOTCH1 | up-regulates quantity by expression 
transcriptional regulation
|
IL7R |
0.328 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-197452 |
|
|
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 22577461 |
E2a positively regulates notch1 expression, which induces the expression of hebalt, bcl11b, and il7r. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL7R | up-regulates
binding
|
JAK1 |
0.623 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-178494 |
|
|
Homo sapiens |
B-lymphocyte |
| pmid |
sentence |
| 18445337 |
For instance, jak1 is associated with the ? Subunits of ?c Cytokines such as il-7r? And IL-4R. jak3 is associated with the ?c20,21. Cytokine binding mediates the trans-phosphorylation of receptor associated jak kinases, which in turn phosphorylate tyrosine residues on the receptors themselves. The receptor phosphotyrosines serve as docking sites for sh2 domain proteins including the stat family of transcription factors which are activated by jak-mediated phosphorylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NOTCH | up-regulates quantity by expression
transcriptional regulation
|
IL7R |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254345 |
|
|
Homo sapiens |
T-lymphocyte |
| pmid |
sentence |
| 22577461 |
Constitutive Notch Activation Upregulates Pax7 and Promotes the Self-Renewal of Skeletal Muscle Satellite Cells |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
IL7R
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