| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279866 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 39534872 |
NFE2L2 is stabilized and translocates to the nucleus, where it dimerizes with sMAF proteins. This complex binds to AREs to mediate the transcription of genes involved in iron metabolism, GSH metabolism, and ROS detoxification. The expression of MT1G during ferroptosis is regulated by the NFE2L2 signaling pathway. In the context of cancer, particularly HCC, the upregulation of MT1G has been linked to resistance against sorafenib, a kinase inhibitor commonly used in cancer therapy |
|