+ |
KEL | up-regulates activity
cleavage
|
EDN3 |
0.663 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-256354 |
Trp117 |
YCHLDIIwINTPEQT |
in vitro |
|
pmid |
sentence |
10438732 |
These data demonstrate that the Kell blood group protein is a proteolytic enzyme that processes big ET-3, generating ET-3, a potent bioactive peptide with multiple biological roles. |
|
Publications: |
1 |
Organism: |
In Vitro |
+ |
CMA1 | up-regulates activity
cleavage
|
EDN3 |
0.382 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-256355 |
Tyr127 |
TPEQTVPyGLSNYRG |
Homo sapiens |
Mast Cell |
pmid |
sentence |
9257865 |
Chymase from human mast cells selectively cleaved big endothelins (ETs) at the Tyr31-Gly32 bond and produced novel trachea-constricting 31-amino acid-length endothelins, ETs(1-31), without any further degradation products. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
EDN3 | up-regulates
binding
|
EDNRB |
0.791 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-36017 |
|
|
Homo sapiens |
|
pmid |
sentence |
8086489 |
These results demonstrate that lys-161 of the receptor is important for high affinity binding with et-3 which, in part, confers the non-selective binding characteristics of the etb receptor for et isopeptides. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
Tissue: |
Ovary |