Name TYR
Full Name Tyrosinase
Synonyms LB24-AB, Monophenol monooxygenase, SK29-AB, Tumor rejection antigen AB
Primary ID P14679
Links - -
Type protein
Relations 3
Function This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine. In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone.


Modifications Tables


Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation TYR 0.14
Publications: 2 Organism: Homo Sapiens
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation TYR 0.14
Publications: 1 Organism: Homo Sapiens