+ |
PRKCB | up-regulates
phosphorylation
|
TYR |
0.421 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-67866 |
Ser523 |
MEKEDYHsLYQSHL |
Homo sapiens |
|
pmid |
sentence |
10347209 |
We conclude that pkc-beta activates tyrosinase directly by phosphorylating serine residues at positions 505 and 509 in the cytoplasmic domain of this melanosome-associated protein. our results strongly suggest that direct phosphorylation of tyrosinase by pkc-_ leads to its activation. |
|
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-67870 |
Ser527 |
DYHSLYQsHL |
Homo sapiens |
Melanoma Cell |
pmid |
sentence |
10347209 |
We conclude that pkc-beta activates tyrosinase directly by phosphorylating serine residues at positions 505 and 509 in the cytoplasmic domain of this melanosome-associated protein. our results strongly suggest that direct phosphorylation of tyrosinase by pkc-_ leads to its activation. |
|
Publications: |
2 |
Organism: |
Homo Sapiens |
+ |
MITF | up-regulates quantity by expression
transcriptional regulation
|
TYR |
0.596 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-254593 |
|
|
Homo sapiens |
Melanocyte |
pmid |
sentence |
10080955 |
Microphthalmia transcription factor MITF, a melanocyte-specific basic helix-loop-helix protein, has been shown to transactivate tyrosinase and TRP-1 genes in vitro by binding to a shared regulatory sequence known as M box. both activation of positive factors such as MITF and inactivation of negative regulatory factors may be required for TRP-1 gene expression during melanocytic differentiation. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |