| + |
JAK1 | up-regulates 
phosphorylation
|
IFNGR1 |
0.691 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-29866 |
Tyr457 |
KAPTSFGyDKPHVLV |
Homo sapiens |
|
| pmid |
sentence |
| 7615558 |
Interferon gamma activation of stat1alpha requires both jak1 and jak2 as well as tyrosine phosphorylation of the alpha chain of the ifngamma receptor. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IFNGR1 | up-regulates activity
binding
|
JAK2 |
0.703 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249505 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23898330 |
In the classical model of IFNgamma signaling, dimeric IFNgamma cross-links the IFNGR1 receptor subunit that results in allosteric changes in receptor cytoplasmic domain. This results in movement of JAK2 from receptor subunit IFNGR2 to IFNGR1. The JAKs autophosphorylate and then phosphorylate IFNGR1 cytoplasmic domain. This results in binding, phosphorylation, and dimer formation of STAT1_. The dimeric STAT1_ dissociates from receptor and undergoes nuclear translocation via an intrinsic NLS for specific gene activation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
JAK1 | up-regulates activity
phosphorylation
|
IFNGR1 |
0.691 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249488 |
|
|
Homo sapiens |
Macrophage |
| pmid |
sentence |
| 19041276 |
The activation of this signaling pathway involves the binding of IFN-g to two IFN-g receptor (IFN-gR) subunits, made up of respective IFNgR1:IFNgR2 pairs, which dimerize upon IFN-g binding to form the IFN-gR complex. Two JAKs, JAK1and JAK2,which bind to each IFN-gR subunits, respectively through their N-terminal domains, both become activated by tyrosine phosphorylation in a JAK2-dependent process. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
JAK2 | up-regulates activity
phosphorylation
|
IFNGR1 |
0.703 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249490 |
|
|
Homo sapiens |
Macrophage |
| pmid |
sentence |
| 23898330 |
In the classical model of IFNgamma signaling, dimeric IFNgamma cross-links the IFNGR1 receptor subunit that results in allosteric changes in receptor cytoplasmic domain. This results in movement of JAK2 from receptor subunit IFNGR2 to IFNGR1. The JAKs autophosphorylate and then phosphorylate IFNGR1 cytoplasmic domain. This results in binding, phosphorylation, and dimer formation of STAT1_. The dimeric STAT1_ dissociates from receptor and undergoes nuclear translocation via an intrinsic NLS for specific gene activation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IFNG | up-regulates activity
binding
|
IFNGR1 |
0.882 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249484 |
|
|
Homo sapiens |
Macrophage |
| pmid |
sentence |
| 23898330 |
In the classical model of IFNgamma signaling, dimeric IFNgamma cross-links the IFNGR1 receptor subunit that results in allosteric changes in receptor cytoplasmic domain. This results in movement of JAK2 from receptor subunit IFNGR2 to IFNGR1. The JAKs autophosphorylate and then phosphorylate IFNGR1 cytoplasmic domain. This results in binding, phosphorylation, and dimer formation of STAT1_. The dimeric STAT1_ dissociates from receptor and undergoes nuclear translocation via an intrinsic NLS for specific gene activation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IFNGR1 | up-regulates
binding
|
JAK2 |
0.703 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-135955 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15864272 |
The only type ii ifn, ifn-, binds a distinct cell-surface receptor, which is known as the type ii ifn receptor. This receptor is also composed of two subunits, ifngr1 and ifngr2, which are associated with jak1 and jak2, respectively. Activation of the jaks that are associated with the type i ifn receptor results in tyrosine phosphorylation of stat2 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-150197 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17063185 |
Interferon- (ifn;type ii ifn) induces reorganization of the ifn-receptor subunits, ifngr1 and ifngr2, activating the janus kinases jak1 and jak2, which are constitutively associated with each subunit, respectively |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
SOCS1 | down-regulates 
binding
|
IFNGR1 |
0.661 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-180140 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18708154 |
Suppressor of cytokine signaling (socs)-1, the key negative regulator of interferon (ifn)-gamma-dependent signaling, is induced in response to ifngamma. Socs-1 binds to and inhibits the ifngamma receptor-associated kinase janus-activated kinase (jak) 2 and inhibits its function in vitrothe binding of socs-1 to tyr441 also blocks the access of stat1 to tyr419 and that this effect may be the principal mechanism of inhibition of downstream signaling |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IFNGR1 | up-regulates
binding
|
JAK1 |
0.691 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-150194 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17063185 |
Interferon- (ifn;type ii ifn) induces reorganization of the ifn-receptor subunits, ifngr1 and ifngr2, activating the janus kinases jak1 and jak2, which are constitutively associated with each subunit, respectively |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-135952 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15864272 |
The only type ii ifn, ifn-g, binds a distinct cell-surface receptor, which is known as the type ii ifn receptor. This receptor is also composed of two subunits, ifngr1 and ifngr2, which are associated with jak1 and jak2, respectively. Activation of the jaks that are associated with the type i ifn receptor results in tyrosine phosphorylation of stat2 |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
IFNGR1 | form complex 
binding
|
IFNGR2/INFGR1 |
0.733 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249485 |
|
|
Homo sapiens |
Macrophage |
| pmid |
sentence |
| 19041276 |
The activation of this signaling pathway involves the binding of IFN-g to two IFN-g receptor (IFN-gR) subunits, made up of respective IFNgR1:IFNgR2 pairs, which dimerize upon IFN-g binding to form the IFN-gR complex. Two JAKs, JAK1and JAK2,which bind to each IFN-gR subunits, respectively through their N-terminal domains, both become activated by tyrosine phosphorylation in a JAK2-dependent process. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IFNG | up-regulates
binding
|
IFNGR1 |
0.882 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-81804 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10986460 |
Molecular interactions among cytokines and cytokine receptors form the basis of many cell-signaling pathways relevant to immune function. Interferon-g (ifng) signals through a multimeric receptor complex consistingof two different but structurally related transmembrane chains: the high-affinityreceptor-binding subunit (ifn-gra) and a species-specific accessory factor (af-1 or ifn-grb). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-95626 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12438563 |
Ifn-g Binds to the ifn-g Receptor binding subunit (ifn-gR1;receptor chain 1), a species-specific cell surface transmembrane receptor chain (41, 42). A second transmembrane protein (ifn-gR2) (4345) is required for signal transduction |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
3.0
IFNGR1
- 
- 