3.0
Summary
| Name |  FOLR1
|
| Full Name | Folate receptor alpha |
| Synonyms | FR-alpha, Adult folate-binding protein, FBP, Folate receptor 1, Folate receptor, adult, KB cells FBP, Ovarian tumor-associated antigen MOv18 | FOLR |
| Primary ID | P15328 |
| Links |  -  -  |
| Type | protein |
| Relations | 1 |
| Function | Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation. |
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Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | FOLR1 | up-regulates quantity 
relocalization
|
(6S)-5-methyltetrahydrofolate(2-) | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |