Summary

Name IFNAR1
Full Name Interferon alpha/beta receptor 1
Synonyms IFN-R-1, IFN-alpha/beta receptor 1, Cytokine receptor class-II member 1, Cytokine receptor family 2 member 1, CRF2-1, Type I interferon receptor 1 | IFNAR
Primary ID P17181
Links - -
Type protein
Relations 8
Function Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1 (PubMed:2153461, PubMed:7665574, PubMed:10049744, PubMed:14532120, PubMed:15337770, PubMed:21854986). Functions in general as heterodimer with IFNAR2 (PubMed:7665574, PubMed:10049744, PubMed:21854986). Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta-subunits themselves (PubMed:7665574, PubMed:21854986, PubMed:32972995). Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity).

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▶Modifications Tables

Relations

Regulator Mechanism target score ℹ
+ TYK2up-regulates activity img/direct-activation.png phosphorylation IFNAR1 0.908
Publications: 2 Organism: In Vitro, Homo Sapiens
+ IFNW1up-regulates img/direct-activation.png binding IFNAR1 0.716
Publications: 1 Organism: Homo Sapiens
+ IFNB1up-regulates img/direct-activation.png binding IFNAR1 0.862
Publications: 1 Organism: Homo Sapiens
+ IFNA1up-regulates img/direct-activation.png binding IFNAR1 0.65
Publications: 1 Organism: Homo Sapiens
+ IFNAR1form complex img/form-complex.png binding IFNAR 0.903
Publications: 1 Organism: Homo Sapiens
+ IFNB1up-regulates activity img/direct-activation.png binding IFNAR1 0.862
Publications: 1 Organism: Chlorocebus Aethiops
+ IFNAR1up-regulates activity img/direct-activation.png phosphorylation PI3K 0.33
Publications: 1 Organism: Homo Sapiens