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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png dephosphorylation PI3K 0.14
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png phosphorylation PI3K 0.22
Publications: 3 Organism: Chlorocebus Aethiops
Pathways:FAP: Insulin-mediated adipogenesis, mTOR in cancer
+ down-regulates activity img/direct_inhibition.png phosphorylation PI3K 0.14
Publications: 1 Organism: Chlorocebus Aethiops
+ down-regulates img/indirect_inhibition.png PI3K 0.14
Publications: 1
+ up-regulates img/direct-activation.png binding PI3K 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/indirect-activation.png AKT1 0.25
Publications: 4 Organism: Homo Sapiens
Tissue: Breast Cancer Cell, Colonic Cancer Cell
+ up-regulates activity img/direct-activation.png binding PIK3CG 0.14
Publications: 1 Organism: Chlorocebus Aethiops
+ down-regulates img/direct_inhibition.png chemical inhibition PI3K 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding PI3K 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle, Myotube
+ up-regulates img/direct-activation.png binding PI3K 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding PI3K 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding PI3K 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding PI3K 0.2
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition PI3K 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition PI3K 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding PI3K 0.2
Publications: 3 Organism: Rattus Norvegicus, Homo Sapiens
Tissue: Skeletal Muscle, Lung Cancer Cell
Pathways:mTOR in cancer
+ up-regulates img/direct-activation.png binding PI3K 0.22
Publications: 1 Organism: Homo Sapiens
Pathways:Integrin Signalling
+ down-regulates img/direct_inhibition.png chemical inhibition PI3K 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition PI3K 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition PI3K 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Breast
+ down-regulates img/direct_inhibition.png chemical inhibition PI3K 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition PI3K 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition PI3K 0.2
Publications: 2 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition PI3K 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates quantity img/direct-activation.png small molecule catalysis, 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate 0.45
Publications: 3 Organism: Homo Sapiens
Pathways:Non-small-cell lung cancer (NSCLC)
+ up-regulates activity img/direct-activation.png binding PI3K 0.22
Publications: 1 Organism: Homo Sapiens
Pathways:Integrin Signalling
+ up-regulates activity img/direct-activation.png binding PI3K 0.2
Publications: 2 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png binding, , phosphorylation PI3K 0.23
Publications: 3 Organism: Mus Musculus, Chlorocebus Aethiops, Homo Sapiens
Pathways:KIT in AML
+ up-regulates activity img/indirect-activation.png AKT 0.4
Publications: 2 Organism: Homo Sapiens
Tissue: Breast Cancer Cell
Pathways:BCR-ABL in AML, FLT3 in AML, KIT in AML, FAP: Insulin-mediated adipogenesis, Integrin Signalling, mTOR in cancer, PI3K/AKT, RTKs in cancer
+ up-regulates img/direct-activation.png binding PI3K 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding PI3K 0.14
Publications: 1 Organism: Mus Musculus
Pathways:FLT3 in AML
+ down-regulates img/direct_inhibition.png chemical inhibition PI3K 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
+ down-regulates img/direct_inhibition.png chemical inhibition PI3K 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding PIK3CD 0.14
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates img/direct-activation.png binding PI3K 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding PI3K 0.28
Publications: 1 Organism: Homo Sapiens
Pathways:RTKs in cancer
+ up-regulates activity img/direct-activation.png phosphorylation AKT 0.4
Publications: 1 Organism: Homo Sapiens
Pathways:BCR-ABL in AML, FLT3 in AML, KIT in AML, FAP: Insulin-mediated adipogenesis, Integrin Signalling, mTOR in cancer, PI3K/AKT, RTKs in cancer
+ up-regulates img/indirect-activation.png Chemotaxis 0.14
Publications: 1
+ up-regulates quantity img/indirect-activation.png superoxide 0.14
Publications: 1
+ down-regulates activity img/indirect_inhibition.png IRS1 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:mTOR in cancer
+ down-regulates img/direct_inhibition.png chemical inhibition PI3K 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding PI3K 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding PI3K 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding PI3K 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:Integrin Signalling
+ up-regulates img/direct-activation.png binding PI3K 0.37
Publications: 2 Organism: Homo Sapiens
Tissue: Breast Cancer Cell
Pathways:PI3K/AKT
+ up-regulates img/direct-activation.png binding PI3K 0.28
Publications: 1 Organism: Homo Sapiens
Pathways:Hepatocellular Tumor, PI3K/AKT
+ down-regulates img/direct_inhibition.png chemical inhibition PI3K 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition PI3K 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition PI3K 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition PI3K 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition PI3K 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png ubiquitination PI3K 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:FLT3 in AML
+ down-regulates img/direct_inhibition.png chemical inhibition PI3K 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding PI3K 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding PI3K 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition PI3K 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png chemical inhibition PI3K 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png RAC1 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Survival 0.2
Publications: 2 Organism: Chlorocebus Aethiops, Homo Sapiens
Tissue: Skeletal Muscle
+ up-regulates img/direct-activation.png binding PI3K 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding PI3K 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates img/direct_inhibition.png dephosphorylation PI3K 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding PI3K 0.14
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates img/direct-activation.png binding PI3K 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/indirect_inhibition.png PI3K 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding PI3K 0.14
Publications: 1 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png binding PI3K 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding PI3K 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding PI3K 0.14
Publications: 1 Organism: Chlorocebus Aethiops
Pathways:Integrin Signalling, PI3K/AKT, RTKs in cancer
+ up-regulates activity img/direct-activation.png binding PI3K 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding PI3K 0.22
Publications: 1 Organism: Homo Sapiens
Pathways:Integrin Signalling, RTKs in cancer
+ up-regulates img/direct-activation.png binding PI3K 0.28
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding PI3K 0.28
Publications: 1 Organism: Homo Sapiens
Pathways:BCR-ABL in AML, FLT3 in AML, KIT in AML
+ down-regulates activity img/direct_inhibition.png phosphorylation BAD 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding PI3K 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation AKT1 0.25
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
+ form complex img/form-complex.png binding PI3K 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:mTOR in cancer
+ form complex img/form-complex.png binding PI3K 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png Proliferation 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
Pathways:BCR-ABL in AML, FLT3 in AML, KIT in AML, Integrin Signalling, mTOR in cancer
+ up-regulates img/direct-activation.png PI3K 0.14
Publications: 1
+ up-regulates img/indirect-activation.png MTOR 0.14
Publications: 1 Organism: Homo Sapiens
Pathways:BCR-ABL in AML, FLT3 in AML, KIT in AML
+ up-regulates activity img/direct-activation.png binding PIK3CB 0.14
Publications: 1 Organism: Chlorocebus Aethiops
+ up-regulates activity img/indirect-activation.png PI3K 0.14
Publications: 1 Organism: Mus Musculus
+ down-regulates img/direct_inhibition.png chemical inhibition PI3K 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PI3K 0.14
Publications: 1 Organism: Homo Sapiens
Tissue: Skeletal Muscle
Pathways:BCR-ABL in AML
+ up-regulates img/indirect-activation.png AKT2 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation BTK 0.14
Publications: 1 Organism: Mus Musculus