3.0
Summary
| Name |  NELFE
|
| Full Name | Negative elongation factor E |
| Synonyms | NELF-E, RNA-binding protein RD | RD, RDBP |
| Primary ID | P18615 |
| Links |  -  -  |
| Type | protein |
| Relations | 1 |
| Function | Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II (PubMed:10199401). The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex (PubMed:11940650, PubMed:12612062). Provides the strongest RNA binding activity of the NELF complex and may initially recruit the NELF complex to RNA (PubMed:18303858, PubMed:27282391). |
binding