| + |
KLF6 | up-regulates quantity by expression 
transcriptional regulation
|
ATF3 |
0.407 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266051 |
|
|
Mus musculus |
LNCaP Cell |
| pmid |
sentence |
| 18755691 |
KLF6 binds directly to and activates the ATF3 promoter. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
ATF3 | up-regulates quantity by expression 
transcriptional regulation
|
ASNS |
0.427 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253746 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12881527 |
Transcription from the ASNS (asparagine synthetase) gene is increased in response to either amino acid (amino acid response) or glucose (endoplasmic reticulum stress response) deprivation. the results provide evidence for a potential role of multiple predicted ATF3 isoforms in the transcriptional regulation of the ASNS gene in response to nutrient deprivation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ATF3 | up-regulates quantity by expression
transcriptional regulation
|
PCLAF |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-201850 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23593430 |
P15(paf) is a direct transcriptional target of atf3 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ATF3 | up-regulates quantity by expression
transcriptional regulation
|
GDF15 |
0.446 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253725 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15670751 |
In addition, DIM increased the expression of NAG-1 as well as activating transcription factor 3 (ATF3), and the induction of ATF3 was earlier than that of NAG-1. The DIM treatment increased luciferase activity of NAG-1 in HCT-116 cells transfected with NAG-1 promoter construct. The results suggest that I3C represses cell proliferation through up-regulation of NAG-1 and that ATF3 may play a pivotal role in DIM-induced NAG-1 expression in human colorectal cancer cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
ATF3
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