Relation Results

Summary

Name ASNS
Full Name Asparagine synthetase [glutamine-hydrolyzing]
Synonyms Cell cycle control protein TS11, Glutamine-dependent asparagine synthetase | TS11
Primary ID P08243
Links - -
Type protein
Relations 12
Pathways Aspartate and asparagine metabolism, Glutamine metabolism
Function

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Type: Score: Layout: SPV 
0.80.80.6410.4190.3810.20.80.80.20.20.8ASNSL-asparagine zwitterionL-glutamate(1-)ATF4ATF3DDIT3SP3AMPL-aspartate(1-)SP1WWTR1L-glutamine zwitterion

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Relations
Regulator
Mechanism
target
score ℹ
+ ASNSup-regulates quantity img/direct-activation.png chemical modification L-asparagine zwitterion 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-267533 Homo sapiens
pmid sentence
Asparagine synthetase (ASNS) converts aspartate and glutamine to asparagine and glutamate in an ATP-dependent reaction. ASNS is present in most, if not all, mammalian organs, but varies widely in basal expression. Human ASNS activity is highly responsive to cellular stress, primarily by increased transcription from a single gene located on chromosome 7.
Publications: 1 Organism: Homo Sapiens
Pathways:Aspartate and asparagine metabolism
+ ASNSup-regulates quantity img/direct-activation.png chemical modification L-glutamate(1-) 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-267535 Homo sapiens
pmid sentence
Asparagine synthetase (ASNS) converts aspartate and glutamine to asparagine and glutamate in an ATP-dependent reaction. ASNS is present in most, if not all, mammalian organs, but varies widely in basal expression. Human ASNS activity is highly responsive to cellular stress, primarily by increased transcription from a single gene located on chromosome 7.
Publications: 1 Organism: Homo Sapiens
Pathways:Aspartate and asparagine metabolism, Glutamine metabolism
+ ATF4down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation ASNS 0.641
Identifier Residue Sequence Organism Cell Line
SIGNOR-253838 Homo sapiens 95D Cell
pmid sentence
C/EBP homology protein (CHOP) interacts with activating transcription factor 4 (ATF4) and negatively regulates the stress-dependent induction of the asparagine synthetase gene.
Publications: 1 Organism: Homo Sapiens
Pathways:Aspartate and asparagine metabolism
+ ATF3up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ASNS 0.419
Identifier Residue Sequence Organism Cell Line
SIGNOR-253746 Homo sapiens
pmid sentence
Transcription from the ASNS (asparagine synthetase) gene is increased in response to either amino acid (amino acid response) or glucose (endoplasmic reticulum stress response) deprivation. the results provide evidence for a potential role of multiple predicted ATF3 isoforms in the transcriptional regulation of the ASNS gene in response to nutrient deprivation.
Publications: 1 Organism: Homo Sapiens
+ ATF4up-regulates quantity by expression img/indirect-activation.png transcriptional regulation ASNS 0.641
Identifier Residue Sequence Organism Cell Line
SIGNOR-253747 Homo sapiens
pmid sentence
Transcription from the asparagine synthetase (A.S.) gene is increased in response to either amino acid (amino acid response) or glucose (endoplasmic reticulum stress response) deprivation. the results provide both in vitro and in vivo evidence for a role of ATF4 in the transcriptional activation of the A.S. gene in response to nutrient deprivation.
Publications: 1 Organism: Homo Sapiens
Pathways:Aspartate and asparagine metabolism
+ DDIT3down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation ASNS 0.381
Identifier Residue Sequence Organism Cell Line
SIGNOR-253837 Homo sapiens HEK-293T Cell
pmid sentence
C/EBP homology protein (CHOP) interacts with activating transcription factor 4 (ATF4) and negatively regulates the stress-dependent induction of the asparagine synthetase gene.
Publications: 1 Organism: Homo Sapiens
+ SP3up-regulates quantity by expression img/direct-activation.png transcriptional regulation ASNS 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-268020 Homo sapiens Hep-G2 Cell
pmid sentence
Sp1 and Sp3 Activate Transcription Driven by the AS Promoter
Publications: 1 Organism: Homo Sapiens
+ ASNSup-regulates quantity img/direct-activation.png chemical modification AMP 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-267534 Homo sapiens
pmid sentence
Asparagine synthetase (ASNS) converts aspartate and glutamine to asparagine and glutamate in an ATP-dependent reaction. ASNS is present in most, if not all, mammalian organs, but varies widely in basal expression. Human ASNS activity is highly responsive to cellular stress, primarily by increased transcription from a single gene located on chromosome 7.
Publications: 1 Organism: Homo Sapiens
Pathways:Aspartate and asparagine metabolism, Glutamine metabolism
+ ASNSdown-regulates quantity img/direct_inhibition.png chemical modification L-aspartate(1-) 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-267531 Homo sapiens
pmid sentence
Asparagine synthetase (ASNS) converts aspartate and glutamine to asparagine and glutamate in an ATP-dependent reaction. ASNS is present in most, if not all, mammalian organs, but varies widely in basal expression. Human ASNS activity is highly responsive to cellular stress, primarily by increased transcription from a single gene located on chromosome 7.
Publications: 1 Organism: Homo Sapiens
Pathways:Aspartate and asparagine metabolism
+ SP1up-regulates quantity by expression img/direct-activation.png transcriptional regulation ASNS 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-268019 Homo sapiens Hep-G2 Cell
pmid sentence
Sp1 and Sp3 Activate Transcription Driven by the AS Promoter
Publications: 1 Organism: Homo Sapiens
+ WWTR1down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation ASNS 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-255608 Homo sapiens Colorectal Cancer Cell
pmid sentence
Efficient knockdown of WWTR1, demonstrated by quantitative real-time PCR, led to upregulation of ASNS and downregulation of SMAD3, LTBR, BAX and BAK1 in WWTR1 knockdown cells, suggesting that these genes may be involved in the repression of cell proliferation.
Publications: 1 Organism: Homo Sapiens
+ ASNSdown-regulates quantity img/direct_inhibition.png chemical modification L-glutamine zwitterion 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-267532 Homo sapiens
pmid sentence
Asparagine synthetase (ASNS) converts aspartate and glutamine to asparagine and glutamate in an ATP-dependent reaction. ASNS is present in most, if not all, mammalian organs, but varies widely in basal expression. Human ASNS activity is highly responsive to cellular stress, primarily by increased transcription from a single gene located on chromosome 7.
Publications: 1 Organism: Homo Sapiens
Pathways:Aspartate and asparagine metabolism, Glutamine metabolism
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