Name PAM
Full Name Peptidyl-glycine alpha-amidating monooxygenase
Synonyms PAM
Primary ID P19021
Links - -
Type protein
Relations 1
Function Bifunctional enzyme that catalyzes 2 sequential steps in C-terminal alpha-amidation of peptides. The monooxygenase part produces an unstable peptidyl(2-hydroxyglycine) intermediate that is dismutated to glyoxylate and the corresponding desglycine peptide amide by the lyase part. C-terminal amidation of peptides such as neuropeptides is essential for full biological activity.


Modifications Tables


Regulator Mechanism target score
+ img/unknown.png phosphorylation PAM 0.31
Publications: 1 Organism: Homo Sapiens