3.0
Summary
| Name |  VCAM1
|
| Full Name | Vascular cell adhesion protein 1 |
| Synonyms | V-CAM 1, VCAM-1, INCAM-100 | L1CAM |
| Primary ID | P19320 |
| Links |  -  -  |
| Type | protein |
| Relations | 2 |
| Function | Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation. |
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Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | AD/b2 integrin | up-regulates activity 
binding
|
VCAM1 | 0.573 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | VCAM1 | up-regulates activity
binding
|
A4/b1 integrin | 0.662 |
| Publications: | 1 | Organism: | Homo Sapiens | |