Summary

Name VCAM1
Full Name Vascular cell adhesion protein 1
Synonyms V-CAM 1, VCAM-1, INCAM-100 | L1CAM
Primary ID P19320
Links - -
Type protein
Relations 3
Function Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation.

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Relations

Regulator Mechanism target score ℹ
+ hsa-mir-126-5pdown-regulates quantity by repression img/direct_inhibition.png post transcriptional regulation VCAM1 0.4
Publications: 1 Organism: Homo Sapiens
+ AD/b2 integrinup-regulates activity img/direct-activation.png binding VCAM1 0.59
Publications: 1 Organism: Homo Sapiens
+ VCAM1up-regulates activity img/direct-activation.png binding A4/b1 integrin 0.675
Publications: 1 Organism: Homo Sapiens