Summary

Name CSNK2A2
Full Name Casein kinase II subunit alpha'
Synonyms CK II alpha' | CK2A2
Primary ID P19784
Links - -
Type protein
Relations 102
Inhibitors [4,5,6,7-Tetrabromo-2-(Dimethylamino)-1h-Benzimidazol-1-Yl]acetic Acid; Silmitasertib
Function Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation. Can also negatively regulate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic regulator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8. Regulates transcription by direct phosphorylation of RNA polymerases I, II, III and IV. Also phosphorylates and regulates numerous transcription factors including NF-kappa-B, STAT1, CREB1, IRF1, IRF2, ATF1, SRF, MAX, JUN, FOS, MYC and MYB. Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function. Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1. Acts as an ectokinase that phosphorylates several extracellular proteins. During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV.

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Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png phosphorylation PTPRC 0.436
Publications: 4 Organism: Homo Sapiens
+ img/unknown.png phosphorylation HMGA1 0.328
Publications: 3 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation PPP1R1B 0.377
Publications: 2 Organism: In Vitro
+ img/unknown.png phosphorylation EEF1B2 0.337
Publications: 2 Organism: In Vitro
+ img/unknown.png phosphorylation SMC3 0.2
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation KIF1C 0.31
Publications: 1 Organism: In Vitro
+ img/unknown.png phosphorylation CLTB 0.308
Publications: 2 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation SCN2A 0.2
Publications: 3 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation EIF4EBP1 0.333
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PPP1R2 0.307
Publications: 3 Organism: In Vitro
+ down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation SPIB 0.307
Publications: 4 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation CDC37 0.492
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation MYF5 0.307
Publications: 2 Organism: In Vitro
+ img/unknown.png phosphorylation STX1A 0.365
Publications: 1 Organism: Rattus Norvegicus
+ img/unknown.png phosphorylation SAT1 0.324
Publications: 3 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation PPP1R8 0.474
Publications: 2 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation FGF14 0.308
Publications: 2 Organism: Homo Sapiens
+ img/unknown.png phosphorylation MS4A1 0.307
Publications: 3 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation UBE2R2 0.451
Publications: 1 Organism: Homo Sapiens
+ img/unknown.png phosphorylation RGS19 0.328
Publications: 1 Organism: In Vitro
+ img/unknown.png phosphorylation HNRNPC 0.326
Publications: 1 Organism: In Vitro
+ img/unknown.png phosphorylation MYCN 0.368
Publications: 2 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation AQP4 0.339
Publications: 3 Organism: Canis Lupus Familiaris
+ up-regulates activity img/direct-activation.png phosphorylation GTF2A1 0.376
Publications: 4 Organism: In Vitro
+ up-regulates quantity by stabilization img/direct-activation.png phosphorylation CTNNB1 0.469
Publications: 3 Organism: In Vitro
+ img/unknown.png phosphorylation ACACA 0.307
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation GTF2A1L 0.416
Publications: 4 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png phosphorylation PTEN 0.703
Publications: 3 Organism: In Vitro
+ img/unknown.png phosphorylation CASQ2 0.376
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation HDAC2 0.391
Publications: 3 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation HDAC1 0.399
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation WAS 0.348
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation HSPH1 0.328
Publications: 1 Organism: In Vitro
+ img/unknown.png phosphorylation SLC18A2 0.307
Publications: 2 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation XRCC1 0.463
Publications: 3 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation CTDP1 0.375
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation TCF7L2 0.379
Publications: 3 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation SUZ12 0.2
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation BID 0.286
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation EIF2B5 0.371
Publications: 2 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation IL16 0.326
Publications: 1 Organism: In Vitro
+ img/unknown.png phosphorylation CAV1 0.356
Publications: 1 Organism: In Vitro
+ down-regulates img/direct_inhibition.png phosphorylation SET (isoform 2) 0.259
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation HSF1 0.35
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation NOL3 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation KLF1 0.343
Publications: 1 Organism: Mus Musculus
+ img/unknown.png phosphorylation ARRB2 0.31
Publications: 1 Organism: In Vitro
+ up-regulates activity img/direct-activation.png phosphorylation CCAR2 0.2
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png phosphorylation DDX58 0.2
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png phosphorylation NKX3-1 0.317
Publications: 2 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png chemical inhibition CSNK2A2 0.8
Publications: 1 Organism: In Vitro
+ img/unknown.png phosphorylation PTPN1 0.342
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png chemical inhibition CSNK2A2 0.8
Publications: 1 Organism: Homo Sapiens