Summary

Name PTPRC
Full Name Receptor-type tyrosine-protein phosphatase C
Synonyms Leukocyte common antigen, L-CA, T200 | CD45
Primary ID P08575
Links - -
Type protein
Relations 27
Pathways T cell activation, Acute Myeloid Leukemia, AML1-ETO in AML
Function Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN. Dephosphorylates LYN, and thereby modulates LYN activity (By similarity).

Viewer

Modifications Tables

Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png phosphorylation PTPRC 0.14
Publications: 4 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png phosphorylation PTPRC 0.14
Publications: 4 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation JAK2 0.28
Publications: 4 Organism: Mus Musculus, Homo Sapiens
Pathways:Acute Myeloid Leukemia, AML1-ETO in AML
+ down-regulates activity img/direct_inhibition.png dephosphorylation JAK1 0.14
Publications: 2 Organism: Mus Musculus
+ down-regulates activity img/direct_inhibition.png dephosphorylation TYK2 0.14
Publications: 2 Organism: Mus Musculus
+ up-regulates img/direct-activation.png phosphorylation PTPRC 0.22
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png dephosphorylation SKAP1 0.35
Publications: 1 Organism: Homo Sapiens
+ down-regulates activity img/direct_inhibition.png dephosphorylation LCK 0.39
Publications: 2 Organism: Homo Sapiens
Pathways:T cell activation
+ down-regulates activity img/direct_inhibition.png dephosphorylation LYN 0.28
Publications: 2 Organism: Mus Musculus
+ up-regulates activity img/direct-activation.png dephosphorylation FYN 0.3
Publications: 1 Organism: Homo Sapiens
Pathways:T cell activation
+ up-regulates img/direct-activation.png dephosphorylation JAK3 0.14
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation PTPRC 0.22
Publications: 1 Organism: Mus Musculus
Pathways:Acute Myeloid Leukemia, AML1-ETO in AML
+ down-regulates activity img/direct_inhibition.png dephosphorylation JAK3 0.14
Publications: 1 Organism: Mus Musculus
+ up-regulates img/direct-activation.png dephosphorylation JAK1 0.14
Publications: 1 Organism: Homo Sapiens