Summary

Name POU3F2
Full Name POU domain, class 3, transcription factor 2
Synonyms Brain-specific homeobox/POU domain protein 2, Brain-2, Brn-2, Nervous system-specific octamer-binding transcription factor N-Oct-3, Octamer-binding protein 7, Oct-7, Octamer-binding transcription factor 7, OTF-7 | BRN2, OCT7, OTF7
Primary ID P20265
Links - -
Type protein
Relations 4
Function Transcription factor that plays a key role in neuronal differentiation (By similarity). Binds preferentially to the recognition sequence which consists of two distinct half-sites, ('GCAT') and ('TAAT'), separated by a non-conserved spacer region of 0, 2, or 3 nucleotides (By similarity). The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Acts downstream of ASCL1, accessing chromatin that has been opened by ASCL1, and promotes transcription of neuronal genes (By similarity).

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Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png binding POU3F2 0.14
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding POU3F2 0.22
Publications: 1 Organism: In Vitro
+ up-regulates quantity by expression img/direct-activation.png transcriptional regulation MITF 0.14
Publications: 1
+ up-regulates quantity by expression img/indirect-activation.png transcriptional regulation GNRH1 0.14
Publications: 1 Organism: Homo Sapiens