| + |
POU3F2 | up-regulates quantity by expression 
transcriptional regulation
|
GNRH1 |
0.284 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254928 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11875100 |
Functional studies demonstrated that Brn-2 increased promoter activity of the human and mouse GnRH genes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GNRH1 | up-regulates activity 
binding
|
EGR1 |
0.456 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254918 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 19106114 |
EGR1 bound to two binding sites on the LHB promoter and this binding was increased by GNRH1. Mutation of either site or knockdown of endogenous EGR1 decreased basal and/or GNRH1-regulated promoter activity. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
triptorelin | up-regulates activity
chemical activation
|
GNRH1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259158 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22416801 |
The comparative effects of degarelix and GnRH agonists were assessed in two studies in a rat model of prostate cancer.14 In a 2‐month study, rats receiving the GnRH agonist, triptorelin (0.5 mg/kg daily), experienced an initial testosterone surge, followed by suppression to castration levels by day 28, which was maintained for the remainder of the study. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GNRH1 | down-regulates activity 
binding
|
AR |
0.473 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259267 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 17202804 |
GnRH antagonizes testosterone activation of the human androgen receptor in SCL60 cells. Gonadotropin-Releasing Hormone Functionally Antagonizes Testosterone Activation of the Human Androgen Receptor in Prostate Cells through Focal Adhesion Complexes Involving Hic-5 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IRF2BPL | up-regulates quantity by expression
transcriptional regulation
|
GNRH1 |
0.429 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267154 |
|
|
Homo sapiens |
Neuron |
| pmid |
sentence |
| 17627301 |
EAP1 encoded a nuclear protein expressed in neurons involved in the inhibitory and facilitatory control of reproduction. EAP1 transactivated genes required for reproductive function, such as GNRH1, and repressed inhibitory genes, such as preproenkephalin. It contained a RING finger domain of the C3HC4 subclass required for this dual transcriptional activity.These results suggest that EAP1 is a transcriptional regulator that, acting within the neuroendocrine brain, contributes to controlling female reproductive function. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PITX2 | down-regulates quantity by repression 
transcriptional regulation
|
GNRH1 |
0.264 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254922 |
|
|
Mus musculus |
LbetaT2 Cell |
| pmid |
sentence |
| 19106114 |
Knockdown of PITX1 or PITX2 isoforms impaired GNRH1 induction, and endogenous PITX1 bound to the candidate PITX binding site on the LHB promoter. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
PITX1 | down-regulates quantity by repression
transcriptional regulation
|
GNRH1 |
0.336 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254921 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 19106114 |
Knockdown of PITX1 or PITX2 isoforms impaired GNRH1 induction, and endogenous PITX1 bound to the candidate PITX binding site on the LHB promoter. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
GNRH1 | up-regulates quantity by expression
transcriptional regulation
|
EGR1 |
0.456 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254917 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 19106114 |
GNRH1 induces expression of early growth response 1 (EGR1), which interacts with steroidogenic factor 1 (SF1) and paired-like homeodomain transcription factor 1 (PITX1) to regulate Lhb promoter activity. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
3.0
GNRH1
- 
- 