Summary

Name PZP
Full Name Pregnancy zone protein
Synonyms C3 and PZP-like alpha-2-macroglobulin domain-containing protein 6 | CPAMD6
Primary ID P20742
Links - -
Type protein
Relations 4
Function Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.

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Modifications Tables

Relations

Regulator Mechanism target score
+ down-regulates quantity by destabilization img/direct_inhibition.png cleavage PZP 0.356
Publications: 1 Organism: In Vitro
+ down-regulates quantity by destabilization img/direct_inhibition.png cleavage PZP 0.334
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png binding MMP2 0.334
Publications: 1 Organism: In Vitro
+ down-regulates activity img/direct_inhibition.png binding MMP9 0.356
Publications: 1 Organism: In Vitro