Name	PZP View Modifications
Full Name	Pregnancy zone protein
Synonyms	C3 and PZP-like alpha-2-macroglobulin domain-containing protein 6 \| CPAMD6
Primary ID	P20742
Links	- -
Type	protein
Relations	4
Function	Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.