| + |
KAT6A | up-regulates 
acetylation
|
TP53 |
0.685 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-201482 |
Lys120 |
FLHSGTAkSVTCTYS |
Homo sapiens |
Leukemia Cell |
| pmid |
sentence |
| 23431171 |
We show here that moz is an acetyltransferase of p53 at k120 and k382 and colocalizes with p53 in promyelocytic leukemia (pml) nuclear bodies following cellular stress. The moz-pml-p53 interaction enhances moz-mediated acetylation of p53, and this ternary complex enhances p53-dependent p21 expression |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-201486 |
Lys382 |
QSTSRHKkLMFKTEG |
Homo sapiens |
Leukemia Cell |
| pmid |
sentence |
| 23431171 |
We show here that moz is an acetyltransferase of p53 at k120 and k382 and colocalizes with p53 in promyelocytic leukemia (pml) nuclear bodies following cellular stress. The moz-pml-p53 interaction enhances moz-mediated acetylation of p53, and this ternary complex enhances p53-dependent p21 expression |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
KAT6A/KAT6B | up-regulates
acetylation
|
TP53 |
0.502 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217194 |
Lys120 |
FLHSGTAkSVTCTYS |
Homo sapiens |
Leukemia Cell |
| pmid |
sentence |
| 23431171 |
We show here that moz is an acetyltransferase of p53 at k120 and k382 and colocalizes with p53 in promyelocytic leukemia (pml) nuclear bodies following cellular stress. The moz-pml-p53 interaction enhances moz-mediated acetylation of p53, and this ternary complex enhances p53-dependent p21 expression |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217198 |
Lys382 |
QSTSRHKkLMFKTEG |
Homo sapiens |
Leukemia Cell |
| pmid |
sentence |
| 23431171 |
We show here that moz is an acetyltransferase of p53 at k120 and k382 and colocalizes with p53 in promyelocytic leukemia (pml) nuclear bodies following cellular stress. The moz-pml-p53 interaction enhances moz-mediated acetylation of p53, and this ternary complex enhances p53-dependent p21 expression |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
NAT10 | up-regulates quantity by stabilization
acetylation
|
TP53 |
0.33 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272406 |
Lys120 |
FLHSGTAkSVTCTYS |
Homo sapiens |
NCI-H1299 Cell |
| pmid |
sentence |
| 26882543 |
NAT10 acetylates p53 at K120 and stabilizes p53 by counteracting Mdm2 action. In addition, NAT10 promotes Mdm2 degradation with its intrinsic E3 ligase activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TRAF6 | up-regulates activity
ubiquitination
|
TP53 |
0.626 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278728 |
Lys24 |
ETFSDLWkLLPENNV |
Homo sapiens |
|
| pmid |
sentence |
| 27818144 |
Here, we show that TRAF6 E3 ligase is a crucial factor to restrict mitochondrial translocation of p53 and spontaneous apoptosis by promoting K63-linked ubiquitination of p53 at K24 in cytosol, and such ubiquitination limits the interaction between p53 and MCL-1/BAK.|We mutated every conserved lysine (K) residue on p53 and found that TRAF6 preferentially ubiquitinates p53 at K24 in the in vivo ubiquitination assay (XREF_FIG, XREF_SUPPLEMENTARY, XREF_SUPPLEMENTARY and XREF_SUPPLEMENTARY). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | EBV infection, P38 Signaling |
| + |
MKRN1 | down-regulates quantity by destabilization 
polyubiquitination
|
TP53 |
0.423 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271846 |
Lys291 |
TEEENLRkKGEPHHE |
Homo sapiens |
NCI-H1299 Cell |
| pmid |
sentence |
| 19536131 |
Makorin Ring Finger Protein 1 (MKRN1) is a transcriptional co-regulator and an E3 ligase. Here, we show that MKRN1 simultaneously functions as a differentially negative regulator of p53 and p21. In normal conditions, MKRN1 could destabilize both p53 and p21 through ubiquitination and proteasome-dependent degradation. As a result, depletion of MKRN1 induced growth arrest through activation of p53 and p21. K291 and K292 of p53 are required for MKRN1-mediated degradation and ubiquitination of p53 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271847 |
Lys292 |
EEENLRKkGEPHHEL |
Homo sapiens |
NCI-H1299 Cell |
| pmid |
sentence |
| 19536131 |
Makorin Ring Finger Protein 1 (MKRN1) is a transcriptional co-regulator and an E3 ligase. Here, we show that MKRN1 simultaneously functions as a differentially negative regulator of p53 and p21. In normal conditions, MKRN1 could destabilize both p53 and p21 through ubiquitination and proteasome-dependent degradation. As a result, depletion of MKRN1 induced growth arrest through activation of p53 and p21. K291 and K292 of p53 are required for MKRN1-mediated degradation and ubiquitination of p53 |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
E4F1 | up-regulates activity
ubiquitination
|
TP53 |
0.624 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271394 |
Lys319 |
TSSSPQPkKKPLDGE |
Homo sapiens |
U2-OS Cell |
| pmid |
sentence |
| 17110336 |
E4F1 Has an Intrinsic Ubiquitin E3 Ligase Activity that Drives K48-type Ubiquitylation of p53. These data demonstrate that E4F1 stimulates the ubiquitylation of p53 on the lysine cluster K319–K321, i.e., at sites distinct from those targeted by Hdm2. p53 forms Ubiquitylated by E4F1 Are Localized on Chromatin. In striking contrast with Ub-p53 forms stimulated by Hdm2, which are mainly cytosoluble and targeted to the proteasome, we found that E4F1-stimulated Ub-p53 forms are tightly associated with chromatin, suggesting that they could be involved in transcription. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271395 |
Lys321 |
SSPQPKKkPLDGEYF |
Homo sapiens |
U2-OS Cell |
| pmid |
sentence |
| 17110336 |
E4F1 Has an Intrinsic Ubiquitin E3 Ligase Activity that Drives K48-type Ubiquitylation of p53. These data demonstrate that E4F1 stimulates the ubiquitylation of p53 on the lysine cluster K319–K321, i.e., at sites distinct from those targeted by Hdm2. p53 forms Ubiquitylated by E4F1 Are Localized on Chromatin. In striking contrast with Ub-p53 forms stimulated by Hdm2, which are mainly cytosoluble and targeted to the proteasome, we found that E4F1-stimulated Ub-p53 forms are tightly associated with chromatin, suggesting that they could be involved in transcription. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
FBXO11 | down-regulates
neddylation
|
TP53 |
0.686 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-150669 |
Lys320 |
SSSPQPKkKPLDGEY |
Homo sapiens |
|
| pmid |
sentence |
| 17098746 |
Fbxo11 promotes the neddylation of p53 and inhibits its transcriptional activity / we found that fbxo11 also neddylates p53 on two lysines, lys-320 and lys-321 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-150673 |
Lys321 |
SSPQPKKkPLDGEYF |
Homo sapiens |
|
| pmid |
sentence |
| 17098746 |
Fbxo11 promotes the neddylation of p53 and inhibits its transcriptional activity / we found that fbxo11 also neddylates p53 on two lysines, lys-320 and lys-321 |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
EP300 | up-regulates
acetylation
|
TP53 |
0.914 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-84070 |
Lys373 |
SSHLKSKkGQSTSRH |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 11070080 |
P300 acetylates and activates the tumor suppressor p53 after dna damage. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-84074 |
Lys382 |
QSTSRHKkLMFKTEG |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 11070080 |
P300 acetylates and activates the tumor suppressor p53 after dna damage. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, p53 in cancer |
| + |
SIRT1 | down-regulates
deacetylation
|
TP53 |
0.817 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-182515 |
Lys382 |
QSTSRHKkLMFKTEG |
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 19047049 |
Sirt1 has been shown to regulate cell fate in part by deacetylating the p53 protein at lysine 382 and inhibiting p53-mediated transcriptional activation and apoptosis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, FLT3-ITD in AML |
| + |
AURKA | up-regulates
phosphorylation
|
TP53 |
0.791 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-199939 |
Ser106 |
SQKTYQGsYGFRLGF |
Homo sapiens |
|
| pmid |
sentence |
| 23201157 |
Ser-106 phosphorylation of p53 decreases its interaction with mdm2 and prolongs the half-life of p53 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPP1CC | down-regulates activity
dephosphorylation
|
TP53 |
0.313 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248499 |
Ser15 |
PSVEPPLsQETFSDL |
Homo sapiens |
|
| pmid |
sentence |
| 16501611 |
Protein serine/threonine phosphatase-1 dephosphorylates p53 at Ser-15 and Ser-37 to modulate its transcriptional and apoptotic activities|In addition, our results reveal that one of the molecular mechanisms by which PP-1 promotes cell survival is to dephosphorylate p53, and thus negatively regulate p53-dependent death pathway. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248500 |
Ser37 |
NVLSPLPsQAMDDLM |
Homo sapiens |
|
| pmid |
sentence |
| 16501611 |
Protein serine/threonine phosphatase-1 dephosphorylates p53 at Ser-15 and Ser-37 to modulate its transcriptional and apoptotic activities|In addition, our results reveal that one of the molecular mechanisms by which PP-1 promotes cell survival is to dephosphorylate p53, and thus negatively regulate p53-dependent death pathway. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
ATM | up-regulates quantity by stabilization
phosphorylation
|
TP53 |
0.852 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-115340 |
Ser15 |
PSVEPPLsQETFSDL |
Homo sapiens |
|
| pmid |
sentence |
| 11875057 |
In response to ionizing radiation (ir), atm, the gene product mutated in ataxia telangiectasia, stabilizes and activates p53 through phosphorylation of ser15 and (indirectly) ser20. Here we show that phosphorylation of p53 on ser46, a residue important for p53 apoptotic activity, as well as on ser9, in response to ir also is dependent on the atm protein kinase. one pathway involves the phosphorylation of p53 and its negative regulator mdm2 by ataxia telangiectasia mutated (atm) and chk2 causing p53 activation and stabilization. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-167152 |
Ser15 |
PSVEPPLsQETFSDL |
Homo sapiens |
|
| pmid |
sentence |
| 20663147 |
Deltanp63 transcriptionally regulates atm to control p53 serine-15 phosphorylation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-158632 |
Ser15 |
PSVEPPLsQETFSDL |
Homo sapiens |
|
| pmid |
sentence |
| 17967874 |
In this study, we show that the increased interaction between B56gamma and p53 after DNA damage requires ATM-dependent phosphorylation of p53 at Ser15. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-126753 |
Ser15 |
PSVEPPLsQETFSDL |
Homo sapiens |
HaCaT Cell |
| pmid |
sentence |
| 15254178 |
Deltanp63 transcriptionally regulates atm to control p53 serine-15 phosphorylation. We next aimed to identify novel factors that control damage-induced p53 phosphorylation in a keratinocyte model system, and discovered that the epithelial stem cell marker _Np63_ is a novel ATM regulator that controls p53 Serine-15 phosphorylation through transcription of the ATM kinase. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-158636 |
Ser20 |
PLSQETFsDLWKLLP |
Homo sapiens |
NCI-H1299 Cell |
| pmid |
sentence |
| 17967874 |
The increased interaction between B56gamma and p53 after DNA damage requires ATM-dependent phosphorylation of p53 at Ser15. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-126757 |
Ser20 |
PLSQETFsDLWKLLP |
Homo sapiens |
U2-OS Cell |
| pmid |
sentence |
| 15254178 |
Although the stabilization of p53 was apparently concordant with its phosphorylation on N-terminal serine residues in HFFF-2 cells, it did not require the phosphorylation of Ser15 or Ser20 by ATM, a cellular kinase known to phosphorylate and promote the stabilization of p53 in response to DNA damage. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-167156 |
Ser20 |
PLSQETFsDLWKLLP |
Homo sapiens |
HaCaT Cell |
| pmid |
sentence |
| 20663147 |
DeltaNp63alpha depletion by RNAi reduces steady-state ATM mRNA and protein levels, and attenuates p53 Serine-15 phosphorylation. Conversely, ectopic expression of DeltaNp63alpha in p63-null tumour cells stimulates ATM transcription and p53 Serine-15 phosphorylation |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-115344 |
Ser46 |
AMDDLMLsPDDIEQW |
Homo sapiens |
|
| pmid |
sentence |
| 11875057 |
In response to ionizing radiation (ir), atm, the gene product mutated in ataxia telangiectasia, stabilizes and activates p53 through phosphorylation of ser15 and (indirectly) ser20. Here we show that phosphorylation of p53 on ser46, a residue important for p53 apoptotic activity, as well as on ser9, in response to ir also is dependent on the atm protein kinase. one pathway involves the phosphorylation of p53 and its negative regulator mdm2 by ataxia telangiectasia mutated (atm) and chk2 causing p53 activation and stabilization. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-115348 |
Ser9 |
EEPQSDPsVEPPLSQ |
Homo sapiens |
|
| pmid |
sentence |
| 11875057 |
In response to ionizing radiation (ir), atm, the gene product mutated in ataxia telangiectasia, stabilizes and activates p53 through phosphorylation of ser15 and (indirectly) ser20. Here we show that phosphorylation of p53 on ser46, a residue important for p53 apoptotic activity, as well as on ser9, in response to ir also is dependent on the atm protein kinase. one pathway involves the phosphorylation of p53 and its negative regulator mdm2 by ataxia telangiectasia mutated (atm) and chk2 causing p53 activation and stabilization. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-151138 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17157788 |
Atm/atr are generally sensors of dna damage, but, together with the checkpoint kinases chk1 and chk2, they also function as response effectors by phosphorylation of key substrates, such as p53, brca1, and nbs1. In particular, p53 phosphorylation leads to protein accumulation and activation, which in turn promotes cell-cycle arrest or apoptosis. |
|
| Publications: |
10 |
Organism: |
Homo Sapiens |
| Pathways: | Colorectal Carcinoma, FLT3-ITD signaling, Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition, p53 in cancer |
| + |
PRKDC | up-regulates
phosphorylation
|
TP53 |
0.803 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-53030 |
Ser15 |
PSVEPPLsQETFSDL |
Homo sapiens |
|
| pmid |
sentence |
| 9363941 |
We demonstrate that phosphorylation of p53 at serines 15 and 37 impairs the ability of mdm2 to inhibit p53-dependent transactivation. We present evidence that these effects are most likely due to a conformational change induced upon phosphorylation of p53. Our studies provide a plausible mechanism by which the induction of p53 can be modulated by dna-pk (or other protein kinases with similar specificity) in response to dna damage. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Cell cycle: G2/M phase transition |
| + |
AMPK | up-regulates
phosphorylation
|
TP53 |
0.468 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-216475 |
Ser15 |
PSVEPPLsQETFSDL |
Homo sapiens |
|
| pmid |
sentence |
| 15866171 |
Ampk activation induces phosphorylation of p53 on serine 15, and this phosphorylation is required to initiate ampk-dependent cell-cycle arrest |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, IDH-TET in AML, FLT3-ITD signaling, Glycolysis and Gluconeogenesis, NPM1_new |
| + |
PPM1D | down-regulates quantity by destabilization
dephosphorylation
|
TP53 |
0.547 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276943 |
Ser15 |
PSVEPPLsQETFSDL |
Homo sapiens |
|
| pmid |
sentence |
| 18265945 |
Dephosphorylation of p53 at serine 15 by Wip1 also contributes to p53 degradation, as does dephosphorylation of Mdm2, which stabilizes Mdm2, an E3 ubiquitin ligase specific for p53 [ xref ]. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | P38 Signaling |
| + |
STK11 | up-regulates
phosphorylation
|
TP53 |
0.769 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-150830 |
Ser15 |
PSVEPPLsQETFSDL |
Homo sapiens |
|
| pmid |
sentence |
| 17108107 |
We show that lkb1 physically associates with p53 in the nucleus and directly or indirectly phosphorylates p53 ser15 (previously shown to be phosphorylated by amp-dependent kinase) and p53 ser392 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-150834 |
Ser392 |
FKTEGPDsD |
Homo sapiens |
|
| pmid |
sentence |
| 17108107 |
We show that lkb1 physically associates with p53 in the nucleus and directly or indirectly phosphorylates p53 ser15 (previously shown to be phosphorylated by amp-dependent kinase) and p53 ser392 |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | FLT3-ITD signaling |
| + |
ATR | up-regulates quantity by stabilization
phosphorylation
|
TP53 |
0.753 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-115134 |
Ser15 |
PSVEPPLsQETFSDL |
Homo sapiens |
|
| pmid |
sentence |
| 11865061 |
Nhibition of atr kinase activity substantially reduces hypoxia-induced phosphorylation of p53 protein on serine 15 as well as p53 protein accumulation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | FLT3-ITD signaling, Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition, p53 in cancer |
| + |
RPS6KA3 | up-regulates activity
phosphorylation
|
TP53 |
0.334 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-279567 |
Ser15 |
PSVEPPLsQETFSDL |
Homo sapiens |
|
| pmid |
sentence |
| 15867353 |
Here we show that ribosomal S6 kinase 2 (RSK2) activates and phosphorylates p53 (Ser15) in vitro and in vivo and colocalizes with p53 in the nucleus. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPP1CA | down-regulates activity
dephosphorylation
|
TP53 |
0.31 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248556 |
Ser15 |
PSVEPPLsQETFSDL |
Homo sapiens |
|
| pmid |
sentence |
| 16501611 |
Protein serine/threonine phosphatase-1 dephosphorylates p53 at Ser-15 and Ser-37 to modulate its transcriptional and apoptotic activities|In addition, our results reveal that one of the molecular mechanisms by which PP-1 promotes cell survival is to dephosphorylate p53, and thus negatively regulate p53-dependent death pathway. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248557 |
Ser37 |
NVLSPLPsQAMDDLM |
Homo sapiens |
|
| pmid |
sentence |
| 16501611 |
Protein serine/threonine phosphatase-1 dephosphorylates p53 at Ser-15 and Ser-37 to modulate its transcriptional and apoptotic activities|In addition, our results reveal that one of the molecular mechanisms by which PP-1 promotes cell survival is to dephosphorylate p53, and thus negatively regulate p53-dependent death pathway. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
PRKAA1 | up-regulates
phosphorylation
|
TP53 |
0.503 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-135960 |
Ser15 |
PSVEPPLsQETFSDL |
Homo sapiens |
|
| pmid |
sentence |
| 15866171 |
Ampk activation induces phosphorylation of p53 on serine 15, and this phosphorylation is required to initiate ampk-dependent cell-cycle arrest |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NUAK1 | up-regulates
phosphorylation
|
TP53 |
0.564 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-172008 |
Ser15 |
PSVEPPLsQETFSDL |
Homo sapiens |
|
| pmid |
sentence |
| 21317932 |
Here we showed that in the presence of wild-type lkb1, nuak1 directly interacts with and phosphorylates p53 in vitro and in vivo. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-172012 |
Ser392 |
FKTEGPDsD |
Homo sapiens |
|
| pmid |
sentence |
| 21317932 |
Here we showed that in the presence of wild-type lkb1, nuak1 directly interacts with and phosphorylates p53 in vitro and in vivo. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
MAPK14 | up-regulates quantity by stabilization
phosphorylation
|
TP53 |
0.784 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-226614 |
Ser15 |
PSVEPPLsQETFSDL |
Homo sapiens |
JB6 Cl41 Cell |
| pmid |
sentence |
| 10781582 |
Serine 15 phosphorylation of p53 leads to a stabilization of p53 by reducing its interaction with murine double minute 2, a negative regulatory partner[...]These results strongly suggest that both ERKs and p38 kinase have a direct role in UVB-induced phosphorylation of p53 at serine 15 in vivo. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | FLT3-ITD signaling, P38 Signaling |
| + |
MAPK3 | up-regulates
phosphorylation
|
TP53 |
0.715 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-100270 |
Ser15 |
PSVEPPLsQETFSDL |
Homo sapiens |
|
| pmid |
sentence |
| 12955074 |
Mutant p53 is constitutively phosphorylated at serine 15 in uv-induced mouse skin tumors: involvement of erk1/2 map kinase. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PPM1D | down-regulates
dephosphorylation
|
TP53 |
0.547 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-135980 |
Ser15 |
PSVEPPLsQETFSDL |
Homo sapiens |
|
| pmid |
sentence |
| 15870257 |
PPM1D also dephosphorylates p53 at phospho-Ser 15. PPM1D dephosphorylations are correlated with reduced cellular intra-S and G2/M checkpoint activity in response to DNA damage induced by ultraviolet and ionizing radiation. Thus, a primary function of PPM1D may be to reverse the p53 and Chk1-induced DNA damage and cell cycle checkpoint responses and return the cell to a homeostatic state following completion of DNA repair. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | P38 Signaling |
| + |
MAPK14 | up-regulates
phosphorylation
|
TP53 |
0.784 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-105737 |
Ser15 |
PSVEPPLsQETFSDL |
Homo sapiens |
MCF-7 Cell |
| pmid |
sentence |
| 11258706 |
P38 regulates p53, but also in p53-defective tumor cells rewire their checkpoint response and become dependent in the p38/mk2 pathway in mcf-7 cells, p38 kinase activated p53 more effectively than other members of the ras pathway. p53 and p38 kinase exist in the same physical complex, and co-expression of p38 stabilized p53 protein. In vitro, p38 kinase phosphorylated p53 at ser33 and ser46, a newly identified site. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-192057 |
Ser33 |
LPENNVLsPLPSQAM |
Homo sapiens |
MCF-7 Cell |
| pmid |
sentence |
| 22975381 |
P38 regulates p53, but also in p53-defective tumor cells rewire their checkpoint response and become dependent in the p38/mk2 pathway in mcf-7 cells, p38 kinase activated p53 more effectively than other members of the ras pathway. p53 and p38 kinase exist in the same physical complex, and co-expression of p38 stabilized p53 protein. In vitro, p38 kinase phosphorylated p53 at ser33 and ser46, a newly identified site. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-105741 |
Ser33 |
LPENNVLsPLPSQAM |
Homo sapiens |
MCF-7 Cell |
| pmid |
sentence |
| 11258706 |
P38 regulates p53, but also in p53-defective tumor cells rewire their checkpoint response and become dependent in the p38/mk2 pathway in mcf-7 cells, p38 kinase activated p53 more effectively than other members of the ras pathway. p53 and p38 kinase exist in the same physical complex, and co-expression of p38 stabilized p53 protein. In vitro, p38 kinase phosphorylated p53 at ser33 and ser46, a newly identified site. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-155242 |
Ser33 |
LPENNVLsPLPSQAM |
Homo sapiens |
MCF-7 Cell |
| pmid |
sentence |
| 17535811 |
P38 regulates p53, but also in p53-defective tumor cells rewire their checkpoint response and become dependent in the p38/mk2 pathway in mcf-7 cells, p38 kinase activated p53 more effectively than other members of the ras pathway. p53 and p38 kinase exist in the same physical complex, and co-expression of p38 stabilized p53 protein. In vitro, p38 kinase phosphorylated p53 at ser33 and ser46, a newly identified site. |
|
| Publications: |
4 |
Organism: |
Homo Sapiens |
| Pathways: | FLT3-ITD signaling, P38 Signaling |
| + |
SMG1 | up-regulates
phosphorylation
|
TP53 |
0.406 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-125135 |
Ser15 |
PSVEPPLsQETFSDL |
Homo sapiens |
|
| pmid |
sentence |
| 15175154 |
Hsmg-1 is a stress-activated kinase that phosphorylates p53 and hupf1 in vitrothe observation that hsmg-1 exhibits p53 (ser-15) kinase activity in vitro suggested that this pikk might be involved in genotoxic stress-induced p53 phosphorylation and stabilization in intact cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CHEK2 | up-regulates quantity by stabilization
phosphorylation
|
TP53 |
0.803 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-75009 |
Ser15 |
PSVEPPLsQETFSDL |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 10673501 |
Chk1/chk2 and atm/atr also phosphorylate the effector p53, increasing its stability.We Have demonstrated that the human homologs of the checkpoint kinases, chk1 and chk2/hcds1, phosphorylate at least three dna damage-inducible phosphorylation sites in p53. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-75629 |
Ser15 |
PSVEPPLsQETFSDL |
Homo sapiens |
|
| pmid |
sentence |
| 10710310 |
Chk1/chk2 and atm/atr also phosphorylate the effector p53, increasing its stability.We Have demonstrated that the human homologs of the checkpoint kinases, chk1 and chk2/hcds1, phosphorylate at least three dna damage-inducible phosphorylation sites in p53. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-74823 |
Ser15 |
PSVEPPLsQETFSDL |
Homo sapiens |
|
| pmid |
sentence |
| 10656682 |
Chk1/chk2 and atm/atr also phosphorylate the effector p53, increasing its stability.We Have demonstrated that the human homologs of the checkpoint kinases, chk1 and chk2/hcds1, phosphorylate at least three dna damage-inducible phosphorylation sites in p53. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-153463 |
Ser15 |
PSVEPPLsQETFSDL |
Homo sapiens |
|
| pmid |
sentence |
| 17339337 |
Chk1/chk2 and atm/atr also phosphorylate the effector p53, increasing its stability. We have demonstrated that the human homologs of the checkpoint kinases, chk1 and chk2/hcds1, phosphorylate at least three dna damage-inducible phosphorylation sites in p53. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-77144 |
Ser20 |
PLSQETFsDLWKLLP |
Homo sapiens |
|
| pmid |
sentence |
| 10801407 |
The tumour suppressor protein p53 is stabilised and activated in response to ionising radiation. This is known to depend on the kinase atm;recent results suggest atm acts via the downstream kinase chk2/hcds1, which stabilises p53 at least in part by direct phosphorylation of residue serine 20 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-75013 |
Ser366 |
PGGSRAHsSHLKSKK |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 10673501 |
Chk1/chk2 and atm/atr also phosphorylate the effector p53, increasing its stability.We Have demonstrated that the human homologs of the checkpoint kinases, chk1 and chk2/hcds1, phosphorylate at least three dna damage-inducible phosphorylation sites in p53. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-75633 |
Ser366 |
PGGSRAHsSHLKSKK |
Homo sapiens |
LNCaP Cell |
| pmid |
sentence |
| 15659650 |
The cell cycle checkpoint kinases CHK1 and CHK2 have been shown to phosphorylate multiple sites in the N-terminal domain of p53, consequently leading to p53 stabilization and activation. Phosphorylation of at least three of these sites, Ser366, Ser378, and Thr387, was induced by DNA damage. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-75017 |
Ser37 |
NVLSPLPsQAMDDLM |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 10673501 |
Chk1/chk2 and atm/atr also phosphorylate the effector p53, increasing its stability.We Have demonstrated that the human homologs of the checkpoint kinases, chk1 and chk2/hcds1, phosphorylate at least three dna damage-inducible phosphorylation sites in p53. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-75637 |
Ser37 |
NVLSPLPsQAMDDLM |
Homo sapiens |
|
| pmid |
sentence |
| 10710310 |
Chk1/chk2 and atm/atr also phosphorylate the effector p53, increasing its stability.We Have demonstrated that the human homologs of the checkpoint kinases, chk1 and chk2/hcds1, phosphorylate at least three dna damage-inducible phosphorylation sites in p53. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-74831 |
Ser37 |
NVLSPLPsQAMDDLM |
Homo sapiens |
|
| pmid |
sentence |
| 10656682 |
Chk1/chk2 and atm/atr also phosphorylate the effector p53, increasing its stability.We Have demonstrated that the human homologs of the checkpoint kinases, chk1 and chk2/hcds1, phosphorylate at least three dna damage-inducible phosphorylation sites in p53. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-153475 |
Ser37 |
NVLSPLPsQAMDDLM |
Homo sapiens |
|
| pmid |
sentence |
| 15659650 |
The cell cycle checkpoint kinases CHK1 and CHK2 have been shown to phosphorylate multiple sites in the N-terminal domain of p53, consequently leading to p53 stabilization and activation. Phosphorylation of at least three of these sites, Ser366, Ser378, and Thr387, was induced by DNA damage. On activation, both of these kinases also phosphorylate multiple sites in the p53 N-terminal domain. These include Ser15, Thr18, Ser20, and Ser37, which are all DNA-damageinducible sites |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-75641 |
Ser378 |
SKKGQSTsRHKKLMF |
Homo sapiens |
|
| pmid |
sentence |
| 10710310 |
Chk1/chk2 and atm/atr also phosphorylate the effector p53, increasing its stability.We Have demonstrated that the human homologs of the checkpoint kinases, chk1 and chk2/hcds1, phosphorylate at least three dna damage-inducible phosphorylation sites in p53. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-153479 |
Ser378 |
SKKGQSTsRHKKLMF |
Homo sapiens |
B-lymphocyte |
| pmid |
sentence |
| 17339337 |
Chk1/chk2 and atm/atr also phosphorylate the effector p53, increasing its stability.We Have demonstrated that the human homologs of the checkpoint kinases, chk1 and chk2/hcds1, phosphorylate at least three dna damage-inducible phosphorylation sites in p53. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-74835 |
Ser378 |
SKKGQSTsRHKKLMF |
Homo sapiens |
LNCaP Cell |
| pmid |
sentence |
| 15659650 |
The cell cycle checkpoint kinases CHK1 and CHK2 have been shown to phosphorylate multiple sites in the N-terminal domain of p53, consequently leading to p53 stabilization and activation. Phosphorylation of at least three of these sites, Ser366, Ser378, and Thr387, was induced by DNA damage. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-75025 |
Thr18 |
EPPLSQEtFSDLWKL |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 10673501 |
Chk1/chk2 and atm/atr also phosphorylate the effector p53, increasing its stability.We Have demonstrated that the human homologs of the checkpoint kinases, chk1 and chk2/hcds1, phosphorylate at least three dna damage-inducible phosphorylation sites in p53. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-75645 |
Thr18 |
EPPLSQEtFSDLWKL |
Homo sapiens |
|
| pmid |
sentence |
| 10710310 |
Chk1/chk2 and atm/atr also phosphorylate the effector p53, increasing its stability.We Have demonstrated that the human homologs of the checkpoint kinases, chk1 and chk2/hcds1, phosphorylate at least three dna damage-inducible phosphorylation sites in p53. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-74839 |
Thr18 |
EPPLSQEtFSDLWKL |
Homo sapiens |
|
| pmid |
sentence |
| 10656682 |
Chk1/chk2 and atm/atr also phosphorylate the effector p53, increasing its stability.We Have demonstrated that the human homologs of the checkpoint kinases, chk1 and chk2/hcds1, phosphorylate at least three dna damage-inducible phosphorylation sites in p53. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-153483 |
Thr18 |
EPPLSQEtFSDLWKL |
Homo sapiens |
B-lymphocyte |
| pmid |
sentence |
| 17339337 |
Chk1/chk2 and atm/atr also phosphorylate the effector p53, increasing its stability.We Have demonstrated that the human homologs of the checkpoint kinases, chk1 and chk2/hcds1, phosphorylate at least three dna damage-inducible phosphorylation sites in p53. |
|
| Publications: |
18 |
Organism: |
Homo Sapiens |
| Pathways: | FLT3-ITD signaling, Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition, p53 in cancer |
| + |
CHEK1 | up-regulates activity
phosphorylation
|
TP53 |
0.792 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217791 |
Ser15 |
PSVEPPLsQETFSDL |
Homo sapiens |
LNCaP Cell |
| pmid |
sentence |
| 15659650 |
CHK1 and CHK2 phosphorylate the p53 N terminus at Ser15, Thr18, Ser20, and Ser37 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217795 |
Ser20 |
PLSQETFsDLWKLLP |
Homo sapiens |
LNCaP Cell |
| pmid |
sentence |
| 15659650 |
CHK1 and CHK2 phosphorylate the p53 N terminus at Ser15, Thr18, Ser20, and Ser37 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217853 |
Ser366 |
PGGSRAHsSHLKSKK |
Homo sapiens |
LNCaP Cell |
| pmid |
sentence |
| 15659650 |
Phosphorylation by chk1 of at least three of these sites, Ser366, Ser378, and Thr387, was induced by DNA damage. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217799 |
Ser37 |
NVLSPLPsQAMDDLM |
Homo sapiens |
LNCaP Cell |
| pmid |
sentence |
| 15659650 |
CHK1 and CHK2 phosphorylate the p53 N terminus at Ser15, Thr18, Ser20, and Ser37 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217857 |
Ser378 |
SKKGQSTsRHKKLMF |
Homo sapiens |
|
| pmid |
sentence |
| 15659650 |
Phosphorylation by chk1 of at least three of these sites, Ser366, Ser378, and Thr387, was induced by DNA damage. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217803 |
Thr18 |
EPPLSQEtFSDLWKL |
Homo sapiens |
|
| pmid |
sentence |
| 15659650 |
CHK1 and CHK2 phosphorylate the p53 N terminus at Ser15, Thr18, Ser20, and Ser37 |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-217861 |
Thr387 |
HKKLMFKtEGPDSD |
Homo sapiens |
LNCaP Cell |
| pmid |
sentence |
| 15659650 |
Phosphorylation by chk1 of at least three of these sites, Ser366, Ser378, and Thr387, was induced by DNA damage. |
|
| Publications: |
7 |
Organism: |
Homo Sapiens |
| Pathways: | FLT3-ITD signaling, Cell cycle: G2/M phase transition |
| + |
DYRK1A | up-regulates
phosphorylation
|
TP53 |
0.412 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-167407 |
Ser15 |
PSVEPPLsQETFSDL |
Homo sapiens |
Neuron |
| pmid |
sentence |
| 20696760 |
Dyrk1a phosphorylates p53 and inhibits proliferation of embryonic neuronal cells. we found that dyrk1a phosphorylates p53 at ser-15 in vitro and in immortalized rat embryonic hippocampal progenitor h19-7 cells. In addition, dyrk1a-induced p53 phosphorylation at ser-15 led to a robust induction of p53 target genes |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDK5 | up-regulates
phosphorylation
|
TP53 |
0.746 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-156414 |
Ser15 |
PSVEPPLsQETFSDL |
Homo sapiens |
Neuron |
| pmid |
sentence |
| 17591690 |
Here, we demonstrate for the first time that cdk5 interacts with p53 and increases its stability through posttranslational regulation, leading to accumulation of p53, particularly in the nucleus. We show that cdk5 phosphorylates p53 on ser15, ser33 and ser46 in vitro, |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-156418 |
Ser20 |
PLSQETFsDLWKLLP |
Homo sapiens |
Neuron |
| pmid |
sentence |
| 17591690 |
Here, we demonstrate for the first time that cdk5 interacts with p53 and increases its stability through posttranslational regulation, leading to accumulation of p53, particularly in the nucleus. We show that cdk5 phosphorylates p53 on ser15, ser33 and ser46 in vitro, |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-156422 |
Ser33 |
LPENNVLsPLPSQAM |
Homo sapiens |
|
| pmid |
sentence |
| 17591690 |
We show that cdk5 phosphorylates p53 on ser15, ser33 and ser46 cdk5-stabilized p53 protein is transcriptionally active |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-156426 |
Ser46 |
AMDDLMLsPDDIEQW |
Homo sapiens |
Neuron |
| pmid |
sentence |
| 17591690 |
We show that cdk5 phosphorylates p53 on ser15, ser33 and ser46 cdk5-stabilized p53 protein is transcriptionally active |
|
| Publications: |
4 |
Organism: |
Homo Sapiens |
| + |
PPM1D | down-regulates activity
dephosphorylation
|
TP53 |
0.547 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248319 |
Ser15 |
PSVEPPLsQETFSDL |
Homo sapiens |
|
| pmid |
sentence |
| 15870257 |
PPM1D binds Chk1 and dephosphorylates the ATR-targeted phospho-Ser 345, leading to decreased Chk1 kinase activity. PPM1D also dephosphorylates p53 at phospho-Ser 15. PPM1D dephosphorylations are correlated with reduced cellular intra-S and G2/M checkpoint activity in response to DNA damage induced by ultraviolet and ionizing radiation. Thus, a primary function of PPM1D may be to reverse the p53 and Chk1-induced DNA damage and cell cycle checkpoint responses and return the cell to a homeostatic state following completion of DNA repair. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | P38 Signaling |
| + |
ROCK1 | up-regulates quantity
phosphorylation
|
TP53 |
0.404 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280108 |
Ser15 |
PSVEPPLsQETFSDL |
Homo sapiens |
|
| pmid |
sentence |
| 33297931 |
Besides, ROCK1 phosphorylated p53 at ser15 to up-regulate its protein level. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MAPK14 | up-regulates activity
phosphorylation
|
TP53 |
0.784 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-72695 |
Ser15 |
PSVEPPLsQETFSDL |
Homo sapiens |
MCF-7 Cell |
| pmid |
sentence |
| 10581258 |
P38 regulates p53, but also in p53-defective tumor cells rewire their checkpoint response and become dependent in the p38/mk2 pathway in mcf-7 cells, p38 kinase activated p53 more effectively than other members of the ras pathway. p53 and p38 kinase exist in the same physical complex, and co-expression of p38 stabilized p53 protein. In vitro, p38 kinase phosphorylated p53 at ser33 and ser46, a newly identified site. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-72699 |
Ser33 |
LPENNVLsPLPSQAM |
Homo sapiens |
MCF-7 Cell |
| pmid |
sentence |
| 10581258 |
P38 regulates p53, but also in p53-defective tumor cells rewire their checkpoint response and become dependent in the p38/mk2 pathway in mcf-7 cells, p38 kinase activated p53 more effectively than other members of the ras pathway. p53 and p38 kinase exist in the same physical complex, and co-expression of p38 stabilized p53 protein. In vitro, p38 kinase phosphorylated p53 at ser33 and ser46, a newly identified site. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250114 |
Ser392 |
FKTEGPDsD |
|
|
| pmid |
sentence |
| 10747897 |
We demonstrate that anisomycin- and tumor necrosis factor--induced phosphorylation of p53 at Ser-392, which is important for the transcriptional activity of this growth suppressor protein, requires p38 MAP kinase |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-226620 |
Ser46 |
AMDDLMLsPDDIEQW |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 15642743 |
Recombinant p38 phosphorylated recombinant p53 on serine 46 in vitro. Inhibition of p38 MAPK by pharmacological inhibitors, dominant-negative p38, or small interfering RNA, suppressed p53S46P |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-72703 |
Ser46 |
AMDDLMLsPDDIEQW |
Homo sapiens |
MCF-7 Cell |
| pmid |
sentence |
| 10581258 |
P38 regulates p53, but also in p53-defective tumor cells rewire their checkpoint response and become dependent in the p38/mk2 pathway in mcf-7 cells, p38 kinase activated p53 more effectively than other members of the ras pathway. p53 and p38 kinase exist in the same physical complex, and co-expression of p38 stabilized p53 protein. In vitro, p38 kinase phosphorylated p53 at ser33 and ser46, a newly identified site. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-155246 |
Ser46 |
AMDDLMLsPDDIEQW |
Homo sapiens |
MCF-7 Cell |
| pmid |
sentence |
| 17535811 |
P38 regulates p53, but also in p53-defective tumor cells rewire their checkpoint response and become dependent in the p38/mk2 pathway in mcf-7 cells, p38 kinase activated p53 more effectively than other members of the ras pathway. p53 and p38 kinase exist in the same physical complex, and co-expression of p38 stabilized p53 protein. In vitro, p38 kinase phosphorylated p53 at ser33 and ser46, a newly identified site. |
|
| Publications: |
6 |
Organism: |
Homo Sapiens, |
| Pathways: | FLT3-ITD signaling, P38 Signaling |
| + |
PPP1CB | down-regulates activity
dephosphorylation
|
TP53 |
0.283 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248572 |
Ser15 |
PSVEPPLsQETFSDL |
Homo sapiens |
|
| pmid |
sentence |
| 16501611 |
Protein serine/threonine phosphatase-1 dephosphorylates p53 at Ser-15 and Ser-37 to modulate its transcriptional and apoptotic activities|In addition, our results reveal that one of the molecular mechanisms by which PP-1 promotes cell survival is to dephosphorylate p53, and thus negatively regulate p53-dependent death pathway. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248573 |
Ser37 |
NVLSPLPsQAMDDLM |
Homo sapiens |
|
| pmid |
sentence |
| 16501611 |
Protein serine/threonine phosphatase-1 dephosphorylates p53 at Ser-15 and Ser-37 to modulate its transcriptional and apoptotic activities|In addition, our results reveal that one of the molecular mechanisms by which PP-1 promotes cell survival is to dephosphorylate p53, and thus negatively regulate p53-dependent death pathway. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
PP1 | down-regulates activity
dephosphorylation
|
TP53 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-264670 |
Ser15 |
PSVEPPLsQETFSDL |
Homo sapiens |
|
| pmid |
sentence |
| 16501611 |
Protein serine/threonine phosphatase-1 dephosphorylates p53 at Ser-15 and Ser-37 to modulate its transcriptional and apoptotic activities|In addition, our results reveal that one of the molecular mechanisms by which PP-1 promotes cell survival is to dephosphorylate p53, and thus negatively regulate p53-dependent death pathway. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TP53RK | up-regulates
phosphorylation
|
TP53 |
0.773 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-157471 |
Ser15 |
PSVEPPLsQETFSDL |
Homo sapiens |
|
| pmid |
sentence |
| 17712528 |
The intrinsic transcriptional activity of p53 was up-regulated by a transient transfection of prpk to cos-7 cells. Prpk was shown to bind to p53 and to phosphorylate p53 at ser-15. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AURKB | down-regulates
phosphorylation
|
TP53 |
0.733 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-197598 |
Ser183 |
CPHHERCsDSDGLAP |
Homo sapiens |
|
| pmid |
sentence |
| 22611192 |
We show that aurora b phosphorylates p53 at s183, t211, and s215 to accelerate the degradation of p53 through the polyubiquitination-proteasome pathway, thus functionally suppressing the expression of p53 target genes involved in cell cycle inhibition and apoptosis (e.g., p21 and puma). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-197602 |
Ser215 |
DRNTFRHsVVVPYEP |
Homo sapiens |
|
| pmid |
sentence |
| 22611192 |
We show that aurora b phosphorylates p53 at s183, t211, and s215 to accelerate the degradation of p53 through the polyubiquitination-proteasome pathway, thus functionally suppressing the expression of p53 target genes involved in cell cycle inhibition and apoptosis (e.g., p21 and puma). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-168745 |
Ser269 |
GNLLGRNsFEVRVCA |
Homo sapiens |
|
| pmid |
sentence |
| 20959462 |
Importantly, the aurora b-mediated phosphorylation on ser(269) or thr(284) significantly compromises p53 transcriptional activity. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-197606 |
Thr211 |
EYLDDRNtFRHSVVV |
Homo sapiens |
|
| pmid |
sentence |
| 22611192 |
We show that aurora b phosphorylates p53 at s183, t211, and s215 to accelerate the degradation of p53 through the polyubiquitination-proteasome pathway, thus functionally suppressing the expression of p53 target genes involved in cell cycle inhibition and apoptosis (e.g., p21 and puma). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-168749 |
Thr284 |
CPGRDRRtEEENLRK |
Homo sapiens |
|
| pmid |
sentence |
| 20959462 |
Importantly, the aurora b-mediated phosphorylation on ser(269) or thr(284) significantly compromises p53 transcriptional activity. |
|
| Publications: |
5 |
Organism: |
Homo Sapiens |
| + |
CHUK | up-regulates activity
phosphorylation
|
TP53 |
0.419 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-280231 |
Ser20 |
PLSQETFsDLWKLLP |
Homo sapiens |
|
| pmid |
sentence |
| 23343355 |
In the nucleus, IKKalpha enhances p53 mediated GADD45 and BAD gene expressions by phosphorylating p53 at Ser20 and stabilizing p53 protein levels , leading to the induction of apoptosis in response to ROS exposure.|PKC-activated nuclear I\u03baB kinase\u03b1 promotes the stability of p53 protein and mediates reactive oxygen species-induced apoptosis [ ]. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DUSP26 | down-regulates activity
dephosphorylation
|
TP53 |
0.358 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248765 |
Ser20 |
PLSQETFsDLWKLLP |
Homo sapiens |
|
| pmid |
sentence |
| 20562916 |
Dual-specificity phosphatase 26 is a novel p53 phosphatase and inhibits p53 tumor suppressor functions in human neuroblastoma|Inhibiting DUSP26 expression in the IMR-32 neuroblastoma cell line enhanced doxorubicin-induced p53 phosphorylation at Ser20 and Ser37, p21, Puma, Bax expression as well as apoptosis |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248766 |
Ser37 |
NVLSPLPsQAMDDLM |
Homo sapiens |
|
| pmid |
sentence |
| 20562916 |
Dual-specificity phosphatase 26 is a novel p53 phosphatase and inhibits p53 tumor suppressor functions in human neuroblastoma|Inhibiting DUSP26 expression in the IMR-32 neuroblastoma cell line enhanced doxorubicin-induced p53 phosphorylation at Ser20 and Ser37, p21, Puma, Bax expression as well as apoptosis |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
CSNK1D | up-regulates
phosphorylation
|
TP53 |
0.593 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-75889 |
Ser20 |
PLSQETFsDLWKLLP |
Homo sapiens |
|
| pmid |
sentence |
| 10734067 |
Here we show that the direct association between a p53 n-terminal peptide and mdm2 is disrupted by phosphorylation of the peptide on thr(18) but not by phosphorylation at other n-terminal sites, including ser(15) and ser(37). Thr(18) was phosphorylated in vitro by casein kinase (ck1). |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-73266 |
Ser20 |
PLSQETFsDLWKLLP |
Homo sapiens |
|
| pmid |
sentence |
| 10606744 |
Protein kinase ck1 is a p53-threonine 18 kinase which requires prior phosphorylation of serine 15. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-73270 |
Thr18 |
EPPLSQEtFSDLWKL |
Homo sapiens |
|
| pmid |
sentence |
| 10606744 |
Protein kinase ck1 is a p53-threonine 18 kinase which requires prior phosphorylation of serine 15. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
DAPK3 | up-regulates
phosphorylation
|
TP53 |
0.397 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-153495 |
Ser20 |
PLSQETFsDLWKLLP |
Homo sapiens |
B-lymphocyte |
| pmid |
sentence |
| 17339337 |
A cell-free ser(20) phosphorylation site assay was used to identify a broad range of calcium calmodulin kinase superfamily members, including chk2, chk1, dapk-1, dapk-3, drak-1, and ampk, as ser(20) kinases.Evaluation of these calcium calmodulin kinase superfamily members as candidate ser(20) kinases in vivo has shown that only chk1 or dapk-1 can stimulate p53 transactivation and induce ser(20) phosphorylation of p53. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CSNK1A1 |
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4.0
TP53
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