Relation Results

Summary

Name CD72
Full Name B-cell differentiation antigen CD72
Synonyms Lyb-2
Primary ID P21854
Links - -
Type protein
Relations 1
Function Plays a role in B-cell proliferation and differentiation.

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Type: Score: Layout: SPV 
0.614PTPN6CD72

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Relations
Regulator
Mechanism
target
score ℹ
+ PTPN6down-regulates img/direct_inhibition.png dephosphorylation CD72 0.614
Identifier Residue Sequence Organism Cell Line
SIGNOR-60155 Homo sapiens B-lymphocyte
pmid sentence
Our work clearly identifies cd72 as both an shp-1 binding protein (figure 1,figure 2) and a direct substrate for shp-1 in vivo (figure 3). As tyrosine phosphorylation of cd72 strongly correlates with the ability of the bcr to deliver growth-inhibitory/apoptosis-inducing signals (figure 4), our results suggest that shp-1-catalyzed dephosphorylation of cd72 may antagonize these signals.
Publications: 1 Organism: Homo Sapiens
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