Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-60155 |
|
|
Homo sapiens |
B-lymphocyte |
pmid |
sentence |
9740800 |
Our work clearly identifies cd72 as both an shp-1 binding protein (figure 1,figure 2) and a direct substrate for shp-1 in vivo (figure 3). As tyrosine phosphorylation of cd72 strongly correlates with the ability of the bcr to deliver growth-inhibitory/apoptosis-inducing signals (figure 4), our results suggest that shp-1-catalyzed dephosphorylation of cd72 may antagonize these signals. |
|