4.0
Summary
| Name |  HNRNPA2B1
|
| Full Name | Heterogeneous nuclear ribonucleoproteins A2/B1 |
| Synonyms | hnRNP A2/B1 | HNRPA2B1 |
| Primary ID | P22626 |
| Links |  -  -  |
| Type | protein |
| Relations | 3 |
| Function | Heterogeneous nuclear ribonucleoprotein (hnRNP) that associates with nascent pre-mRNAs, packaging them into hnRNP particles. The hnRNP particle arrangement on nascent hnRNA is non-random and sequence-dependent and serves to condense and stabilize the transcripts and minimize tangling and knotting. Packaging plays a role in various processes such as transcription, pre-mRNA processing, RNA nuclear export, subcellular location, mRNA translation and stability of mature mRNAs (PubMed:19099192). Forms hnRNP particles with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleus. Involved in transport of specific mRNAs to the cytoplasm in oligodendrocytes and neurons |
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Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | HNRNPA2B1 | down-regulates quantity by repression 
transcriptional regulation
|
CDK5R1 | 0.2 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | FUS | down-regulates quantity by repression
post transcriptional regulation
|
HNRNPA2B1 | 0.512 |
| Publications: | 1 | Organism: | Mus Musculus | |
| + | MYC | up-regulates quantity by expression 
transcriptional regulation
|
HNRNPA2B1 | 0.358 |
| Publications: | 1 | Organism: | Homo Sapiens | |