| + |
TRAF6 | down-regulates activity 
ubiquitination
|
MYC |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278563 |
Lys148 |
K-->C |
Homo sapiens |
|
| pmid |
sentence |
| 35045331 |
We posited that TRAF6 ubiquitination of MYC at K148 prevents its acetylation, which results in diminished MYC activity ( xref ). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CSNK2A1 | down-regulates quantity by destabilization
phosphorylation
|
MYC |
0.516 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276388 |
Ser267 |
PPTTSSDsEEEQEDE |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 22025562 |
Together, our findings provide evidence for CK1α-mediated destruction of c-Myc and identify c-Myc S252 as a crucial CK1α phosphorylation site for c-Myc degradation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CSNK1A1 | down-regulates quantity by destabilization
phosphorylation
|
MYC |
0.286 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-276387 |
Ser267 |
PPTTSSDsEEEQEDE |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 22025562 |
Together, our findings provide evidence for CK1α-mediated destruction of c-Myc and identify c-Myc S252 as a crucial CK1α phosphorylation site for c-Myc degradation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Wnt in cancer, WNT Signaling, WNT/FLT3 |
| + |
MAPK9 | up-regulates 
phosphorylation
|
MYC |
0.367 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-72104 |
Ser62 |
LLPTPPLsPSRRSGL |
Homo sapiens |
|
| pmid |
sentence |
| 10551811 |
The jnk pathway is selectively involved in the c-myc-mediated apoptosis and that the apoptotic function of c-myc is directly regulated by jnk pathway through phosphorylation at ser-62 and ser-71. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-72108 |
Ser71 |
SRRSGLCsPSYVAVT |
Homo sapiens |
|
| pmid |
sentence |
| 10551811 |
The jnk pathway is selectively involved in the c-myc-mediated apoptosis and that the apoptotic function of c-myc is directly regulated by jnk pathway through phosphorylation at ser-62 and ser-71. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
MAPK1 | up-regulates activity
phosphorylation
|
MYC |
0.727 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-235700 |
Ser62 |
LLPTPPLsPSRRSGL |
Chlorocebus aethiops |
COS Cell |
| pmid |
sentence |
| 8386367 |
Transactivation of gene expression by myc is inhibited by mutation at the phosphorylation sites thr-58 and ser-62. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| Pathways: | Nucleotide Biosynthesis |
| + |
MAPK8 | up-regulates activity
phosphorylation
|
MYC |
0.571 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236018 |
Ser62 |
LLPTPPLsPSRRSGL |
Homo sapiens |
HEK-293 Cell, HeLa Cell |
| pmid |
sentence |
| 10551811 |
The jnk pathway is selectively involved in the c-myc-mediated apoptosis and that the apoptotic function of c-myc is directly regulated by jnk pathway through phosphorylation at ser-62 and ser-71. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236384 |
Ser71 |
SRRSGLCsPSYVAVT |
Homo sapiens |
HEK-293 Cell, HeLa Cell |
| pmid |
sentence |
| 10551811 |
The jnk pathway is selectively involved in the c-myc-mediated apoptosis and that the apoptotic function of c-myc is directly regulated by jnk pathway through phosphorylation at ser-62 and ser-71. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, EGFR Signaling, FLT3-ITD in AML, WNT Signaling, WNT/FLT3 |
| + |
ERK1/2 | up-regulates quantity by stabilization
phosphorylation
|
MYC |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252079 |
Ser62 |
LLPTPPLsPSRRSGL |
Rattus norvegicus |
Embryonic Fibroblast |
| pmid |
sentence |
| 11018017 |
Phosphorylation of Ser 62 is required for Ras-induced stabilization of Myc, likely mediated through the action of ERK. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| Pathways: | Acute Myeloid Leukemia, BCR-ABL in AML, FLT3 in AML, KIT in AML, AML_TRIPLETS, Colorectal Carcinoma, EGFR Signaling, FLT3-ITD in AML, FLT3-ITD signaling, Hepatocellular Tumor, Nucleotide Biosynthesis, Triple mutant AML, NPM1_new, Rhabdomyosarcoma, Thyroid cancer, WNT/FLT3 |
| + |
MAPK3 | up-regulates activity
phosphorylation
|
MYC |
0.698 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-236250 |
Ser62 |
LLPTPPLsPSRRSGL |
in vitro |
|
| pmid |
sentence |
| 32482868 |
ERK1 phosphorylates MYC Ser62 resulting in MYC stabilization and activation |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
PPP2CB | down-regulates
dephosphorylation
|
MYC |
0.279 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-149726 |
Ser62 |
LLPTPPLsPSRRSGL |
Homo sapiens |
|
| pmid |
sentence |
| 16987807 |
Phosphorylation at ser-62 by pro-directed kinases (p-k) is a prerequisite for gsk3-dependent phosphorylation of thr-58. This triggers binding of pin1, subsequently protein phosphatase 2a (pp2a)-dependent dephosphorylation of ser-62, and then recruitment of scf-fbw7 to the thr-58-phosphorylated myc. Scf-fbw7 polyubiquitinylates myc (branching through lys-48), leading to its proteasomal degradation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PAK2 | down-regulates activity
phosphorylation
|
MYC |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278489 |
Thr358 |
ISNNRKCtSPRSSDT |
Homo sapiens |
|
| pmid |
sentence |
| 14749374 |
Here we demonstrate that Pak2 phosphorylates Myc at three sites (T358, S373, and T400) and affects Myc functions both in vitro and in vivo. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278490 |
Thr400 |
T-->E |
Homo sapiens |
|
| pmid |
sentence |
| 14749374 |
Here we demonstrate that Pak2 phosphorylates Myc at three sites (T358, S373, and T400) and affects Myc functions both in vitro and in vivo. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
RNF115 | down-regulates quantity by destabilization
ubiquitination
|
MYC |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278662 |
Thr58 |
T-->P |
Homo sapiens |
|
| pmid |
sentence |
| 22844532 |
These results suggest that Rabring7 antagonizes function of c-Myc possibly through degradation of c-Myc.|Unexpectedly, we found that Rabring7 more strongly binds to c-Myc than to MM-1 (XREF_FIG) and that Rabring7 stimulates poly-ubiquitination of c-Myc in a T58 dependent manner (XREF_FIG). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
BRD4 | down-regulates quantity by destabilization
phosphorylation
|
MYC |
0.577 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262046 |
Thr58 |
KKFELLPtPPLSPSR |
Homo sapiens |
|
| pmid |
sentence |
| 32482868 |
We report that BRD4 phosphorylates MYC at Thr58, leading to MYC ubiquitination and degradation, thereby regulating MYC target genes. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GSK3B | down-regulates quantity by destabilization
phosphorylation
|
MYC |
0.712 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-118844 |
Thr58 |
KKFELLPtPPLSPSR |
Homo sapiens |
|
| pmid |
sentence |
| 14563837 |
Conversely, overexpression of gsk-3 alpha or gsk-3 beta enhances thr-58 phosphorylation and ubiquitination of c-myc |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252080 |
Thr58 |
KKFELLPtPPLSPSR |
Rattus norvegicus |
|
| pmid |
sentence |
| 11018017 |
Phosphorylation of Thr 58, likely mediated by GSK-3 but dependent on the prior phosphorylation of Ser 62, is associated with degradation of Myc. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-138603 |
Thr58 |
KKFELLPtPPLSPSR |
Homo sapiens |
|
| pmid |
sentence |
| 16023596 |
Similar to c-myc, we report here that phosphorylation of c-jun by gsk3 creates a high-affinity binding site for the e3 ligase fbw7, which targets c-jun for polyubiquitination and proteasomal degradation. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens, Rattus Norvegicus |
| Pathways: | Acute Myeloid Leukemia, AML_TRIPLETS, FLT3-ITD signaling, Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition, Triple mutant AML, WNT/FLT3 |
| + |
GSK3A | down-regulates quantity by destabilization
phosphorylation
|
MYC |
0.413 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-138596 |
Thr58 |
KKFELLPtPPLSPSR |
Homo sapiens |
|
| pmid |
sentence |
| 16023596 |
Similar to c-myc, similar to c-myc, we report here that phosphorylation of c-jun by gsk3 creates a high-affinity binding site for the e3 ligase fbw7, which targets c-jun for polyubiquitination and proteasomal degradation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ABL1 | up-regulates activity
phosphorylation
|
MYC |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278196 |
Tyr74 |
Y-->P |
Homo sapiens |
|
| pmid |
sentence |
| 23318434 |
Altogether, our data demonstrate that Pin1 and Abl cooperate to enhance the interaction of Myc with p300 and its resulting acetylation.|These experiments confirmed that Myc Y74 is phosphorylated by Abl, and provided us with a reagent to detect this form of Myc in cells (see below). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Cell cycle: G2/M phase transition |
| + |
MYC | down-regulates quantity by repression
transcriptional regulation
|
CDKN1A |
0.774 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-102740 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12835716 |
C-myc also directly represses transcription of cdk kinase inhibitors including p27kip1, p21cip1, p15ink4b and p16ink4a |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, FLT3-ITD in AML, FLT3-ITD signaling, Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition, Rhabdomyosarcoma |
| + |
TRPC4AP | down-regulates quantity by destabilization
binding
|
MYC |
0.356 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271963 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 20551172 |
We characterize a new Myc-interacting factor, TRPC4AP (transient receptor potential cation channel, subfamily C, member 4-associated protein)/TRUSS (tumor necrosis factor receptor-associated ubiquitous scaffolding and signaling protein), which is the receptor for a DDB1 (damage-specific DNA-binding protein 1)-CUL4 (Cullin 4) E3 ligase complex for selective Myc degradation through the proteasome. TRPC4AP/TRUSS binds specifically to the Myc C terminus and promotes its ubiquitination and destruction through the recognition of evolutionarily conserved domains in the Myc N terminus. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MYC | down-regulates activity
binding
|
YY1 |
0.559 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268795 |
|
|
Mus musculus |
NIH-3T3 Cell |
| pmid |
sentence |
| 8266081 |
Inhibition of transcriptional regulator Yin-Yang-1 by association with c-Myc.Yin-Yang-1 (YY1) regulates the transcription of many genes, including the oncogenes c-fos and c-myc. Depending on the context, YY1 acts as a transcriptional repressor, a transcriptional activator, or a transcriptional initiator. In cotransfections, c-Myc inhibits both the repressor and the activator functions of YY1, which suggests that one way c-Myc acts is by modulating the activity of YY1. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | NOTCH Signaling |
| + |
MYC | up-regulates quantity by expression
transcriptional regulation
|
IMPDH2 |
0.298 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267375 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18677108 |
Analysis of in vivo C-MYC interactions with TS, IMPDH2 and PRPS2 genes confirmed that they are direct C-MYC targets. C-MYC depletion did not significantly affect levels of E2F1 protein reported to regulate expression of many S-phase specific genes, but resulted in the repression of several genes encoding enzymes rate-limiting for dNTP metabolism. These included thymidylate synthase (TS), inosine monophosphate dehydrogenase 2 (IMPDH2) and phosphoribosyl pyrophosphate synthetase 2 (PRPS2). C-MYC depletion also resulted in reduction in the amounts of deoxyribonucleoside triphosphates (dNTPs) and inhibition of proliferation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267377 |
|
|
Homo sapiens |
P493-6 Cell |
| pmid |
sentence |
| 18628958 |
Here, we report that the majority of genes in human purine and pyrimidine biosynthesis pathway were induced and directly bound by c-Myc in the P493-6 human Burkitt's lymphoma model cell line. The mRNA levels of IMPDH1 and IMPDH2, the rate-limiting enzyme in purine de novo synthesis, increased with MYC induction both in vitro and in vivo. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Pathways: | Nucleotide Biosynthesis |
| + |
MYC | up-regulates quantity by expression 
transcriptional regulation
|
ST3GAL3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253962 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22547830 |
We provide evidence that ST3GAL1/3/4 and FUT3 are transcriptionally up-regulated by c-Myc with probable involvement of Ser62 phosphorylation, and that FUT2 is transcriptionally down-regulated through the attenuation of CDX2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PIN1 | up-regulates
binding
|
MYC |
0.558 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-202134 |
|
|
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 23716601 |
Pin1 prolyl isomerase enhances recruitment of serine 62-phosphorylated myc and its coactivators to select promoters during gene activation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MYC | up-regulates quantity
transcriptional regulation
|
SLC2A1 |
0.441 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259987 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 10823814 |
C-Myc directly transactivates genes encoding GLUT1, phosphofructokinase, and enolase and increases glucose uptake in Rat1 fibroblasts. Nuclear run-on studies confirmed that the GLUT1 transcriptional rate is elevated by c-Myc. Our findings suggest that overexpression of the c-Myc oncoprotein deregulates glycolysis through the activation of several components of the glucose metabolic pathway. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
MYC | up-regulates activity
binding
|
DNMT3A |
0.703 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255806 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19786833 |
Based on one of these publications, we here showed that the interaction of Dnmt3a with c-myc promote the specific methylation of CG dinucleotides localized in c-myc boxes of promoter regions of CDKN2a, CCND1 and TIMP2 genes. Acellular experiments corroborated and complemented these results by revealing that the specificity of consensus sequence for DNA methylation of Dnmt3a is increased in presence of c-myc. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, DNMT3A in AML, miRNA in AML, AML_TRIPLETS, Triple mutant AML |
| + |
MYC | down-regulates quantity by repression 
transcriptional regulation
|
HLA-F |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254605 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8206526 |
In melanoma, HLA class I expression is suppressed by overexpression of the c-myc oncogene. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MYC | up-regulates quantity by expression
transcriptional regulation
|
CCNE1 |
0.623 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-49130 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9188852 |
Our results suggest that this activation may involve at least two myc-dependent steps: the induction of cyclin e gene transcription followed by accumulation of cyclin e mrna in a protein synthesis-independent manner and the p27(kip1) association with cyce/cdk2 complexes containing newly synthesised cyce. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MYC | up-regulates quantity by expression
transcriptional regulation
|
SHMT2 |
0.295 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267380 |
|
|
Homo sapiens |
P493-6 Cell |
| pmid |
sentence |
| 18628958 |
Myc regulates the de novo purine and pyrimidine synthetic genes in multiple biological systems. Intriguingly, MYC was found to directly activate the expression of SHMT1, and SHMT2, which are enzymes involved in single carbon metabolism and are essential for dNTP synthesis |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MYC | up-regulates quantity
transcriptional regulation
|
Enolase |
0.422 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267785 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 10823814 |
C-Myc directly transactivates genes encoding GLUT1, phosphofructokinase, and enolase and increases glucose uptake in Rat1 fibroblasts. Nuclear run-on studies confirmed that the GLUT1 transcriptional rate is elevated by c-Myc. Our findings suggest that overexpression of the c-Myc oncoprotein deregulates glycolysis through the activation of several components of the glucose metabolic pathway. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270247 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 10823814 |
C-Myc directly transactivates genes encoding GLUT1, phosphofructokinase, and enolase and increases glucose uptake in Rat1 fibroblasts. Nuclear run-on studies confirmed that the GLUT1 transcriptional rate is elevated by c-Myc. Our findings suggest that overexpression of the c-Myc oncoprotein deregulates glycolysis through the activation of several components of the glucose metabolic pathway. |
|
| Publications: |
2 |
Organism: |
Rattus Norvegicus |
| + |
SMAD3 | down-regulates quantity by repression
transcriptional regulation
|
MYC |
0.675 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251494 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11689553 |
Down-regulation of c-Myc is a critical event for growth inhibition induced by transforming growth factor-β (TGF-β) and is frequently impaired in cancer cells. We determined a Smad-responsive element in the c-mycpromoter. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Colorectal Carcinoma, Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition, Hepatocellular Tumor |
| + |
MYC | down-regulates quantity by repression
transcriptional regulation
|
HECTD4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267144 |
|
|
Homo sapiens |
LNCaP Cell |
| pmid |
sentence |
| 32814769 |
We identified several E3 ligases as strong candidates responsible for AR and MYC protein loss as HECTD4, MYCBP2, and TRIM49. HECTD4 and MYCBP2 target AR and MYC for degradation while TRIM49 appears to promote AR and MYC stability. We have shown that these E3 ligases in turn are directly regulated by MYC. MYC in turn represses the expression of ubiquitin ligases, HECTD4 and MYCBP2 that promote AR and MYC protein degradation, further suppressing MYC and AR in a feed forward loop. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
USP13 | up-regulates quantity by stabilization
deubiquitination
|
MYC |
0.36 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-274124 |
|
|
Homo sapiens |
Glioma Stem Cell |
| pmid |
sentence |
| 27923907 |
In this study, we demonstrate that the deubiquitinase USP13 stabilizes c-Myc by antagonizing FBXL14-mediated ubiquitination to maintain GSC self-renewal and tumorigenic potential. USP13 was preferentially expressed in GSCs, and its depletion potently inhibited GSC proliferation and tumor growth by promoting c-Myc ubiquitination and degradation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MYC | down-regulates quantity by repression
transcriptional regulation
|
HLA-C |
0.259 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254602 |
|
|
Homo sapiens |
Melanoma Cell |
| pmid |
sentence |
| 8206526 |
In melanoma, HLA class I expression is suppressed by overexpression of the c-myc oncogene. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MYC | up-regulates quantity by expression
transcriptional regulation
|
SURF1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254615 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10858544 |
We show that although the Surf-1/Surf-2 promoter does not contain Myc binding sites (E-boxes), Myc over-expression, or the activation of a Myc-oestrogen receptor fusion protein, activates transcription in the Surf-1 direction and that this response to Myc requires a functional YY1 binding site. Our data suggest that the MAP kinase cascade is required for the stimulation of Surf-1 promoter activity and that the Myc-YY1 interaction mediates this response. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MYC | down-regulates quantity by repression
transcriptional regulation
|
CDKN2A |
0.761 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267575 |
|
|
Homo sapiens |
Lymphoma Cell |
| pmid |
sentence |
| 20551174 |
In tissue culture, ectopic expression of Myc suppresses the cell cycle arrest that occurs in response to several anti-mitogenic signals such as transforming growth factor β (TGFβ), since Myc represses expression of the cyclin-dependent kinase inhibitors (CKIs) p15ink4b, p21cip1, and p57kip2 via interaction with Miz1 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, AML1-ETO in AML, DNMT3A in AML, NPM1 in AML, Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition, Triple mutant AML, NPM1_new, Rhabdomyosarcoma |
| + |
SIRT2 | up-regulates quantity by stabilization
|
MYC |
0.476 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255148 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23175188 |
Here we demonstrated that the class III histone deacetylase SIRT2 was upregulated by N-Myc in neuroblastoma cells and by c-Myc in pancreatic cancer cells, and that SIRT2 enhanced N-Myc and c-Myc protein stability and promoted cancer cell proliferation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MYC | down-regulates quantity by repression
transcriptional regulation
|
MYCBP2 |
0.423 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267145 |
|
|
Homo sapiens |
LNCaP Cell |
| pmid |
sentence |
| 32814769 |
We identified several E3 ligases as strong candidates responsible for AR and MYC protein loss as HECTD4, MYCBP2, and TRIM49. HECTD4 and MYCBP2 target AR and MYC for degradation while TRIM49 appears to promote AR and MYC stability. We have shown that these E3 ligases in turn are directly regulated by MYC. MYC in turn represses the expression of ubiquitin ligases, HECTD4 and MYCBP2 that promote AR and MYC protein degradation, further suppressing MYC and AR in a feed forward loop. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FUBP1 | up-regulates quantity by expression
transcriptional regulation
|
MYC |
0.423 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259123 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26490982 |
The human far upstream element (FUSE) binding protein 1 (FUBP1) belongs to an ancient family which is required for proper regulation of the c-Myc proto-oncogene. Our results indicated that FUBP1 may potentially stimulate c-Myc expression in ESCC and its expression may promote ESCC progression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HECTD4 | down-regulates quantity by destabilization
ubiquitination
|
MYC |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267146 |
|
|
Homo sapiens |
LNCaP Cell |
| pmid |
sentence |
| 32814769 |
We identified several E3 ligases as strong candidates responsible for AR and MYC protein loss as HECTD4, MYCBP2, and TRIM49. HECTD4 and MYCBP2 target AR and MYC for degradation while TRIM49 appears to promote AR and MYC stability. We have shown that these E3 ligases in turn are directly regulated by MYC. MYC in turn represses the expression of ubiquitin ligases, HECTD4 and MYCBP2 that promote AR and MYC protein degradation, further suppressing MYC and AR in a feed forward loop. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DLX5 | up-regulates quantity
transcriptional regulation
|
MYC |
0.278 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-241914 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19497851 |
Here we demonstrate by luciferase assay that the MYC promoter is specifically activated by overexpression of DLX5 and that two DLX5 binding sites in the MYC promoter are important for transcriptional activation of MYC. We also show that DLX5 binds to the MYC promoter both in vitro and in vivo and that transfection of a DLX5 expression plasmid promotes the expression of MYC in a dose-dependent manner in mammalian cells |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ARID5B | up-regulates quantity by expression
transcriptional regulation
|
MYC |
0.278 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256156 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 29326336 |
ARID5B transcriptionally activates the oncogene MYC in T-ALL cells |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ZMIZ1 | up-regulates quantity by expression
transcriptional regulation
|
MYC |
0.37 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263939 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 26522984 |
The N-terminal domain (NTD) of Zmiz1 is important for driving Myc transcription and proliferation […] Zmiz1 directly interacted with Notch1 via a tetratricopeptide repeat domain at a special class of Notch-regulatory sites. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
MYC | up-regulates quantity by expression
transcriptional regulation
|
SIRT2 |
0.476 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255146 |
|
|
Homo sapiens |
Pancreatic Cancer Cell |
| pmid |
sentence |
| 23175188 |
Here we demonstrated that the class III histone deacetylase SIRT2 was upregulated by N-Myc in neuroblastoma cells and by c-Myc in pancreatic cancer cells, and that SIRT2 enhanced N-Myc and c-Myc protein stability and promoted cancer cell proliferation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RBPJ/NOTCH | up-regulates quantity by expression
transcriptional regulation
|
MYC |
0.617 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-209593 |
|
|
Homo sapiens |
Lymphoma Cell |
| pmid |
sentence |
| 16847353 |
C-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia/lymphoma |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | NOTCH Signaling |
| + |
MYC | up-regulates quantity
transcriptional regulation
|
Hexokinase |
0.463 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270270 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17785433 |
Here, using the P493-6 Burkitt's lymphoma model with an inducible MYC, we demonstrate that HIF-1 cooperates with dysregulated c-Myc to promote glycolysis by induction of hexokinase 2, which catalyzes the first step of glycolysis, and pyruvate dehydrogenase kinase 1, which inactivates pyruvate dehydrogenase and diminishes mitochondrial respiration. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MYC | down-regulates quantity by repression
transcriptional regulation
|
DKK1 |
0.396 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-245355 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17485441 |
C-Myc suppresses the Wnt inhibitors DKK1 and SFRP1, and derepression of DKK1 or SFRP1 reduces Myc-dependent transforming activity |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | WNT Signaling, WNT/FLT3 |
| + |
MYC | down-regulates activity
|
BRD4 |
0.577 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-262047 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 32482868 |
Conversely, MYC inhibits BRD4's HAT activity, suggesting that MYC regulates its own transcription by limiting BRD4-mediated chromatin remodeling of its locus. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MYC | up-regulates quantity by expression
transcriptional regulation
|
CLK3 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-274123 |
|
|
Homo sapiens |
Cholangiocarcinoma Cell Line |
| pmid |
sentence |
| 32453420 |
C-Myc enhances transcriptional activation of CLK3 promoter in CCA cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
ERG | up-regulates quantity by expression
transcriptional regulation
|
MYC |
0.286 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251554 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25277175 |
Increased expression of ERG or other ETS factors under control of androgen responsive promoter (TMPRSS2) is an inevitable consequence of the fusion events, and it activates transcriptional program that contributes to oncogenesis by upregulating expression of, among others, MYC, EZH2 and SOX9 and repressing NKX3. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Prostate Cancer |
| + |
PML-RARalpha | up-regulates activity
|
MYC |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256374 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19855079 |
We demonstrate that in addition to blocking myeloid differentiation, PLZF-RARα also promotes proliferation/self-renewal via the aberrant regulation of cell cycle–associated genes such as c-Myc, providing a basis for studying the aberrant response of this leukemia subtype to retinoic acid. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, FLT3 in AML |
| + |
MYC | up-regulates quantity by expression
transcriptional regulation
|
CUL1 |
0.495 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-102749 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12835716 |
Furthermore, c-myc activation can also promote the degradation of p27kip1 protein by directly activating the cul1 gene, which encodes a critical component of the ubiquitin ligase scfskp2 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MYC | down-regulates quantity by repression
transcriptional regulation
|
miR-23b |
0.4 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255916 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 16731620 |
Moreover, both loci encoding miR-1, miR-1-1, and miR-1-2, and two of the three encoding miR-133, miR-133a-1 and miR-133a-2, are strongly induced during myogenesis.[…]By using CHIP analysis, we demonstrate that the myogenic factors Myogenin and MyoD bind to regions upstream of these microRNAs and, therefore, are likely to regulate their expression. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
SCF-FBW7 | down-regulates quantity
ubiquitination
|
MYC |
0.582 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-243757 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20852628 |
We now show that the F-box protein Fbw7 interacts with and thereby destabilizes c-Myc in a manner dependent on phosphorylation of MB1. Whereas wild-type Fbw7 promoted c-Myc turnover in cells, an Fbw7 mutant lacking the F-box domain delayed it. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SMAD2/SMAD4 | down-regulates quantity by repression
transcriptional regulation
|
MYC |
0.652 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256291 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11689553 |
To identify this pathway, we analyzed TGF-β-responsive elements in the human c-myc promoter and found that Smad proteins directly bound to an element in the c-myc promoter and suppressed c-myc promoter activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hepatocellular Tumor |
| + |
SCF-betaTRCP | up-regulates quantity
ubiquitination
|
MYC |
0.48 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-243542 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20852628 |
Here we show that SCF²-TrCP binds to Myc by means of a characteristic phosphodegron and ubiquitylates Myc; this results in enhanced Myc stability. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MYC | down-regulates quantity by repression
transcriptional regulation
|
CDKN1B |
0.546 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-107032 |
|
|
Homo sapiens |
Breast Cancer Cell, T-lymphocyte |
| pmid |
sentence |
| 11313917 |
P27(kip1) gene is a target of transcriptional repression by c-myc. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Muscle, Smooth Muscle |
| Pathways: | Acute Myeloid Leukemia, Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition |
| + |
MYC | up-regulates quantity by expression
transcriptional regulation
|
PFK |
0.336 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267587 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 10823814 |
C-Myc directly transactivates genes encoding GLUT1, phosphofructokinase, and enolase and increases glucose uptake in Rat1 fibroblasts. Nuclear run-on studies confirmed that the GLUT1 transcriptional rate is elevated by c-Myc. Our findings suggest that overexpression of the c-Myc oncoprotein deregulates glycolysis through the activation of several components of the glucose metabolic pathway. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
USP28 | up-regulates
deubiquitination
|
MYC |
0.694 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-155590 |
|
|
Homo sapiens |
Breast Cancer Cell |
| pmid |
sentence |
| 17558397 |
Usp28, an ubiquitin-specific protease, binds to myc through an interaction with fbw7alpha, an f-box protein that is part of an scf-type ubiquitin ligase. Therefore, it stabilizes myc. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MYC | down-regulates quantity by repression
transcriptional regulation
|
miR-23a |
0.4 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268045 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19219026 |
Here we report that the c-Myc (hereafter referred to as Myc) oncogenic transcription factor, which is known to regulate microRNAs and stimulate cell proliferation, transcriptionally represses miR-23a and miR-23b, resulting in greater expression of their target protein, mitochondrial glutaminase, in human P-493 B lymphoma cells and PC3 prostate cancer cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SCF-SKP2 | down-regulates quantity
ubiquitination
|
MYC |
0.573 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-243551 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20852628 |
The F-box protein Skp2 mediates c-Myc ubiquitylation by binding to the MB2 domain |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MYC | up-regulates quantity by expression
transcriptional regulation
|
PPAT |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267381 |
|
|
Homo sapiens |
P493-6 Cell |
| pmid |
sentence |
| 18628958 |
PPAT, catalyzing the first step of purine synthesis, and DHODH, an enzyme generating uridine in the middle of the pyrimidine synthesis pathway, were validated as direct c-MYC target genes by all criteria. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Nucleotide Biosynthesis |
| + |
RFX1 | down-regulates quantity by repression
transcriptional regulation
|
MYC |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253829 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12032779 |
Several different transcription factors have been implicated in the down-regulation of c-myc expression during differentiation, including C/EBPalpha, CTCF, BLIMP-1, and RFX1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MYC | up-regulates quantity by expression
transcriptional regulation
|
CDK4 |
0.584 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-102734 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12835716 |
C-myc directly activates transcription of cyclin d1, cyclin d2 and cdk4, and leads to cdk 4/6 activation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CTNNB1 | up-regulates quantity by expression
transcriptional regulation
|
MYC |
0.739 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-19153 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 16510874 |
Beta-cat promotes h3k4 trimethylation at the c-myc gene in vivo. H3k4 trimethylation in vivo requires prior ubiquitination of h2b, and we find that ubiquitin is necessary for transcription initiation on chromatin but not nonchromatin templates in vitro.Chromatin Immunoprecipitation experiments reveal that beta-cat recruits pygopus, bcl-9/legless, and mll/set1-type complexes to the c-myc enhancertogether with the negative wnt regulators, apc, and betatrcp. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, AML1-ETO in AML, FLT3 in AML, Colorectal Carcinoma, FLT3-ITD in AML, FLT3-ITD signaling, Hepatocellular Tumor, Rhabdomyosarcoma, Thyroid cancer, Wnt in cancer, WNT Signaling, WNT/FLT3 |
| + |
MYC | down-regulates quantity by repression
transcriptional regulation
|
HLA-E |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254604 |
|
|
Homo sapiens |
Melanoma Cell |
| pmid |
sentence |
| 8206526 |
In melanoma, HLA class I expression is suppressed by overexpression of the c-myc oncogene. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MYC | up-regulates quantity
transcriptional regulation
|
HK2 |
0.378 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259986 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17785433 |
Here, using the P493-6 Burkitt's lymphoma model with an inducible MYC, we demonstrate that HIF-1 cooperates with dysregulated c-Myc to promote glycolysis by induction of hexokinase 2, which catalyzes the first step of glycolysis, and pyruvate dehydrogenase kinase 1, which inactivates pyruvate dehydrogenase and diminishes mitochondrial respiration. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MYC | up-regulates quantity by expression
transcriptional regulation
|
CCND2 |
0.462 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-27446 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 7526316 |
C-myc directly activates transcription of cyclin d1, cyclin d2 and cdk4, and leads to cdk 4/6 activation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PLK1 | up-regulates activity
phosphorylation
|
MYC |
0.546 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-243522 |
|
|
Homo sapiens |
HEK-293 Cell, Colorectal Adenocarcinoma Cell Line |
| pmid |
sentence |
| 23887393 |
Here, we report that PDK1 directly induces phosphorylation of Polo-like kinase 1 (PLK1), which in turn induces MYC phosphorylation and protein accumulation. We show that PDK1-PLK1-MYC signaling is critical for cancer cell growth and survival, and small-molecule inhibition of PDK1/PLK1 provides an effective approach for therapeutic targeting of MYC dependency |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SMAD3 | down-regulates quantity by repression
transcriptional regulation
|
MYC |
0.675 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-123087 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14993291 |
Smad3 is required for both tgf-beta-induced repression of c-myc and subsequent growth arrest in keratinocytes |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Colorectal Carcinoma, Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition, Hepatocellular Tumor |
| + |
MYC | down-regulates quantity by repression
transcriptional regulation
|
CDKN2A |
0.761 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-102743 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12835716 |
C-myc also directly represses transcription of cdk kinase inhibitors including p27kip1, p21cip1, p15ink4b and p16ink4a |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, AML1-ETO in AML, DNMT3A in AML, NPM1 in AML, Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition, Triple mutant AML, NPM1_new, Rhabdomyosarcoma |
| + |
MYC | up-regulates quantity by stabilization
|
SIRT1 |
0.588 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261558 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26049753 |
Overexpression of c-MYC resulted in SIRT1 deubiquitination, whereas c-MYC knockdown led to decrease in SIRT1 protein stability and expression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, FLT3-ITD in AML |
| + |
MAX | up-regulates
binding
|
MYC |
0.733 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-39137 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8425218 |
In vivo transactivation assays suggest that myc-max and mad-max complexes have opposing functions in transcription and that max plays a central role in this network of transcription factors |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | EGFR Signaling |
| + |
MYC | down-regulates quantity by repression
transcriptional regulation
|
SFRP1 |
0.364 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-245360 |
|
|
Homo sapiens |
IMEC Cell, Mammary Epithelial Cell |
| pmid |
sentence |
| 17485441 |
c-Myc suppresses the Wnt inhibitors DKK1 and SFRP1, and derepression of DKK1 or SFRP1 reduces Myc-dependent transforming activity |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | WNT Signaling, WNT/FLT3 |
| + |
CEBPA | down-regulates quantity by repression
transcriptional regulation
|
MYC |
0.501 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253830 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12032779 |
Several different transcription factors have been implicated in the down-regulation of c-myc expression during differentiation, including C/EBPalpha, CTCF, BLIMP-1, and RFX1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, AML1-ETO in AML, FLT3 in AML, AML_TRIPLETS, FLT3-ITD in AML, Triple mutant AML, NPM1_new |
| + |
CTCF | down-regulates quantity by repression
transcriptional regulation
|
MYC |
0.64 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253827 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12032779 |
Several different transcription factors have been implicated in the down-regulation of c-myc expression during differentiation, including C/EBPalpha, CTCF, BLIMP-1, and RFX1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GH1 | up-regulates quantity by expression
transcriptional regulation
|
MYC |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261627 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15665309 |
Autocrine hGH increased the transcription and subsequent mRNA level and protein expression of c-Myc, Cyclin D1, and Bcl-2 in human mammary epithelial cells |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MYC | up-regulates
|
Proliferation |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-56572 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 9552384 |
C-myc has emerged as one of the central regulators of mammalian cell proliferation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255414 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21408055 |
We have demonstrated that following muscle damage, phosphorylated STAT3 (p-STAT3) in SCs increases early (within one hour), inducing downstream target genes (i.e. GP130 and SOCS3), which further regulate the increase in STAT3 production and response (as induced via IL-6), leading to increased cMyc expression, which drives cell proliferation |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259110 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 7882978 |
These observations indicate that continued late-stage expression of L-myc affected differentiation processes directly, rather than indirectly through deregulated growth control, whereas constitutive c-myc expression inhibited proliferative arrest, but did not appear to disturb differentiation. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens, Mus Musculus |
| Tissue: |
Skeletal Muscle, Lens Fiber |
| Pathways: | Acute Myeloid Leukemia, AML1-ETO in AML, BCR-ABL in AML, DNMT3A in AML, FLT3 in AML, KIT in AML, miRNA in AML, MLL fusion protein in AML, NPM1 in AML, AML_TRIPLETS, Colorectal Carcinoma, EGFR Signaling, FLT3-ITD in AML, FLT3-ITD signaling, Hepatocellular Tumor, mTOR in cancer, Triple mutant AML, NPM1_new, Prostate Cancer, Rhabdomyosarcoma, Thyroid cancer, Wnt in cancer, WNT Signaling, WNT/FLT3 |
| + |
SMAD3/SMAD4 | down-regulates quantity by repression
transcriptional regulation
|
MYC |
0.653 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256290 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11689553 |
To identify this pathway, we analyzed TGF-β-responsive elements in the human c-myc promoter and found that Smad proteins directly bound to an element in the c-myc promoter and suppressed c-myc promoter activity. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hepatocellular Tumor |
| + |
ENO1 | down-regulates quantity by repression
transcriptional regulation
|
MYC |
0.422 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261594 |
|
|
Chlorocebus aethiops |
CV-1 Cell |
| pmid |
sentence |
| 2005901 |
This result suggests that MBP-1 in vivo acts as a sequence-specific repressor. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
LEF1 | up-regulates quantity by expression
transcriptional regulation
|
MYC |
0.625 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-245351 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19653274 |
Expression of Lef-1 FL, but not the newly identified Lef-1 Deltaexon VI, induced the expression of the cell cycle regulating proteins c-myc and cyclin D1 in cooperation with beta-catenin and it enhanced cell proliferation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Colorectal Carcinoma, Hepatocellular Tumor, Wnt in cancer, WNT Signaling, WNT/FLT3 |
| + |
B-WICH complex | up-regulates activity
binding
|
MYC |
0.299 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268842 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 25883140 |
The B-WICH complex allows c-Myc to bind to a site in the IGS. c-Myc requires the B-WICH complex to remodel chromatin for its function. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MYC | up-regulates quantity
transcriptional regulation
|
ENO1 |
0.422 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259989 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 10823814 |
C-Myc directly transactivates genes encoding GLUT1, phosphofructokinase, and enolase and increases glucose uptake in Rat1 fibroblasts. Nuclear run-on studies confirmed that the GLUT1 transcriptional rate is elevated by c-Myc. Our findings suggest that overexpression of the c-Myc oncoprotein deregulates glycolysis through the activation of several components of the glucose metabolic pathway. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
Cullin4-RBX1-DDB1 | down-regulates quantity by destabilization
polyubiquitination
|
MYC |
0.384 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271965 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 20551172 |
We characterize a new Myc-interacting factor, TRPC4AP (transient receptor potential cation channel, subfamily C, member 4-associated protein)/TRUSS (tumor necrosis factor receptor-associated ubiquitous scaffolding and signaling protein), which is the receptor for a DDB1 (damage-specific DNA-binding protein 1)-CUL4 (Cullin 4) E3 ligase complex for selective Myc degradation through the proteasome. TRPC4AP/TRUSS binds specifically to the Myc C terminus and promotes its ubiquitination and destruction through the recognition of evolutionarily conserved domains in the Myc N terminus. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MYC | up-regulates quantity by expression
transcriptional regulation
|
GLS |
0.453 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268038 |
|
|
Homo sapiens |
B-lymphoma Cell Line |
| pmid |
sentence |
| 19219026 |
Here we report that the c-Myc (hereafter referred to as Myc) oncogenic transcription factor, which is known to regulate microRNAs and stimulate cell proliferation, transcriptionally represses miR-23a and miR-23b, resulting in greater expression of their target protein, mitochondrial glutaminase, in human P-493 B lymphoma cells and PC3 prostate cancer cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RLIM | down-regulates quantity by destabilization
ubiquitination
|
MYC |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278551 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 27684546 |
This suggests that RLIM negatively regulates the transcriptional activity of c-Myc.|We further showed that RLIM can promote polyubiquitination of c-Myc in cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MYC | down-regulates activity
binding
|
SMAD3 |
0.675 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-114284 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11804592 |
Through its direct interaction with smads, c-myc binds to the sp1-smad complex on the promoter of the p15(ink4b) gene, thereby inhibiting the tgf-beta-induced transcriptional activity of sp1 and smad/sp1-dependent transcription of the p15(ink4b) gene. These results suggest that oncogenic c-myc promotes cell growth and cancer development partly by inhibiting the growth inhibitory functions of smads. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Colorectal Carcinoma, Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition, Hepatocellular Tumor |
| + |
ZBTB14 | down-regulates quantity by repression
transcriptional regulation
|
MYC |
0.321 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-220537 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 10080939 |
ZF5, which we have cloned as a transcriptional repressor on the mouse c-myc promoter |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
TRIM32 | down-regulates quantity by destabilization
ubiquitination
|
MYC |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-278676 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19269368 |
TRIM32 ubiquitinates and degrades the transcription factor c-Myc but also binds Argonaute-1 and thereby increases the activity of specific microRNAs. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MYC | down-regulates
|
SMAD2 |
0.674 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-114281 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11804592 |
Oncogenic c-myc promotes cell growth and cancer development partly by inhibiting the growth inhibitory functions of smads |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hepatocellular Tumor |
| + |
FBXW7 | down-regulates quantity
ubiquitination
|
MYC |
0.756 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-243545 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20852628 |
We now show that the F-box protein Fbw7 interacts with and thereby destabilizes c-Myc in a manner dependent on phosphorylation of MB1. Whereas wild-type Fbw7 promoted c-Myc turnover in cells, an Fbw7 mutant lacking the F-box domain delayed it. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, DNMT3A in AML, NPM1 in AML, AML_TRIPLETS, Triple mutant AML, NPM1_new |
| + |
MYC | up-regulates quantity by expression
transcriptional regulation
|
CDC25A |
0.617 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-245465 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11154267 |
Expression of Cdc25A is transcriptionally regulated by Myc and E2F-1 , both of which are expressed in MCF-7 cells in response to estrogen |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition |
| + |
GATA6 | up-regulates quantity by expression
|
MYC |
0.375 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253152 |
|
|
Homo sapiens |
CACO-2 Cell |
| pmid |
sentence |
| 24317510 |
Many GATA6-dependent genes lacked nearby binding sites but several strongly dependent, synexpressed and GATA6-bound genes encode TFs such as MYC, HES1, RARB and CDX2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDR2 | up-regulates activity
binding
|
MYC |
0.51 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252000 |
|
|
|
|
| pmid |
sentence |
| 20383333 |
Here we find that cdr2 is cell cycle regulated in tumor cells with protein levels peaking in mitosis. As cells exit mitosis, cdr2 is ubiquitinated by the anaphase promoting complex/cyclosome (APC/C) and rapidly degraded by the proteasome. Previously we showed that cdr2 binds to the oncogene c-myc, and here we extend this observation to show that cdr2 and c-myc interact to synergistically regulate c-myc-dependent transcription during passage through mitosis. |
|
| Publications: |
1 |
| + |
JAK2 | up-regulates quantity by expression
transcriptional regulation
|
MYC |
0.463 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255811 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 12370803 |
In this study, we show that Jak2 is involved in c-Myc induction by inducing c-MYC mRNA and protecting c-Myc protein from 26S proteasome-dependent degradation. These results indicate that c-Myc is a downstream target of activated Jak2 in Bcr-Abl positive cells. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Acute Myeloid Leukemia, AML1-ETO in AML, BCR-ABL in AML, FLT3 in AML, KIT in AML, EGFR Signaling |
| + |
MYC | up-regulates quantity by expression
transcriptional regulation
|
NFE2L2 |
0.532 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267363 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 29731393 |
Oncogenic proteins that regulate proliferation, such as KRAS, BRAF, and MYC increase the transcription of NRF2 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hepatocellular Tumor, Nucleotide Biosynthesis, Pentose phosphate pathway |
| + |
MYC | up-regulates quantity by expression
transcriptional regulation
|
PRPS2 |
0.281 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267376 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18677108 |
Analysis of in vivo C-MYC interactions with TS, IMPDH2 and PRPS2 genes confirmed that they are direct C-MYC targets. C-MYC depletion did not significantly affect levels of E2F1 protein reported to regulate expression of many S-phase specific genes, but resulted in the repression of several genes encoding enzymes rate-limiting for dNTP metabolism. These included thymidylate synthase (TS), inosine monophosphate dehydrogenase 2 (IMPDH2) and phosphoribosyl pyrophosphate synthetase 2 (PRPS2). C-MYC depletion also resulted in reduction in the amounts of deoxyribonucleoside triphosphates (dNTPs) and inhibition of proliferation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Pentose phosphate pathway |
| + |
CNBP | down-regulates quantity by repression
transcriptional regulation
|
MYC |
0.308 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261571 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 23774591 |
These data verified that the binding of CNBP with c-myc promoter G-quadruplex can indeed down-regulate its associated gene expression for a certain period of time. This result with human CNBP is somehow consistent with previous reports that c-myc G-quadruplex serves as a silencer of c-myc transcription [7] and CNBP promotes the formation of c-myc G-quadruplex. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PRDM1 | down-regulates quantity by repression
transcriptional regulation
|
MYC |
0.447 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-99119 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12626569 |
The positive regulatory domain i binding factor 1 (prdi-bf1 or blimp-1) protein represses the transcription of specific target genes, including c-myc, the mhc class ii trans-activator, pax-5, and cd23b |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MYC | up-regulates quantity by expression
transcriptional regulation
|
BCR |
0.37 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272144 |
|
|
Homo sapiens |
K-562 Cell, LAMA-84 Cell |
| pmid |
sentence |
| 26179066 |
In the present study we demonstrate that MYC and its partner MAX bind to the BCR promoter, leading to up-regulation of BCR and BCR/ABL1 at both transcriptional and protein levels.|Here we describe a regulatory pathway modulating BCR and BCR/ABL1 expression, showing that the BCR promoter is under the transcriptional control of the MYC/MAX heterodimer. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RUNX1 | down-regulates quantity by repression
transcriptional regulation
|
MYC |
0.342 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-260093 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 29958106 |
RUNX1 represses MYC expression through direct binding at three downstream enhancer elements |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, FLT3 in AML, KIT in AML, miRNA in AML, MLL fusion protein in AML, NPM1_new |
| + |
TRiC | up-regulates quantity by stabilization
binding
|
MYC |
0.271 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272872 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 36185250 |
Mammalian cells contain an evolutionarily conserved type II chaperonin called chaperonin containing tailless complex polypeptide 1 (CCT) or tailless complex polypeptide 1 ring complex (TRiC). The CCT complex is composed of eight subunits [CCT1-8 (yeast) or CCTα-θ (mammals)] and folds substrates needed for cell invasion and proliferation, such as actin, tubulin, and cell division cycle protein 20 homolog (cdc20), as well as oncoproteins like signal transducer and activator of transcription 3 (STAT3), Kirsten rat sarcoma viral oncogene homolog (KRAS), and Myelocytomatosis (MYC). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SATB1 | down-regulates quantity by repression
transcriptional regulation
|
MYC |
0.406 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-224831 |
|
|
Homo sapiens |
Hematopoietic Stem Cell |
| pmid |
sentence |
| 23563689 |
Satb1 simultaneously repressed sets of genes encoding molecules involved in HSC activation and cellular polarity, including Numb and Myc |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FLT3 | up-regulates quantity by expression
|
MYC |
0.371 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261556 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25280219 |
MYC expression was relatively higher (P <0Æ1) in theFLT3/ITD-positive AML samples compared to non-mutant FLT3 AML. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, AML1-ETO in AML, FLT3 in AML, miRNA in AML, AML_TRIPLETS, FLT3-ITD in AML, FLT3-ITD signaling, Triple mutant AML, NPM1_new, WNT/FLT3 |
| + |
MYC | up-regulates quantity by expression
transcriptional regulation
|
HNRNPA2B1 |
0.363 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268691 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20010808 |
We also demonstrate that the oncogenic transcription factor c-Myc upregulates transcription of PTB, hnRNPA1 and hnRNPA2, |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
JAK2 | up-regulates quantity by stabilization
binding
|
MYC |
0.463 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255810 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 12370803 |
In this study, we show that Jak2 is involved in c-Myc induction by inducing c-MYC mRNA and protecting c-Myc protein from 26S proteasome-dependent degradation. These results indicate that c-Myc is a downstream target of activated Jak2 in Bcr-Abl positive cells. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Acute Myeloid Leukemia, AML1-ETO in AML, BCR-ABL in AML, FLT3 in AML, KIT in AML, EGFR Signaling |
| + |
NSD3 | up-regulates quantity by stabilization
binding
|
MYC |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259199 |
|
|
Homo sapiens |
HEK-293T Cell |
| pmid |
sentence |
| 28205554 |
Indeed, dose-dependent TR-FRET and affinity pull-down assay confirmed the interaction of NSD3-s with MYC. Supporting functional significance of the interaction, co-expression of NSD3-s, but not the MYC-binding defective fragment of NSD3-s (1–347), stabilized MYC protein and increased MYC transcriptional activity as revealed by a MYC-driven reporter assay. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
DOT1L | up-regulates activity
binding
|
MYC |
0.341 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-239362 |
|
|
Homo sapiens |
MCF-10A Cell |
| pmid |
sentence |
| 26199140 |
Our data suggest that the c-Myc-dependent transcriptional switch is modulated by DOT1L, as in the presence of DOT1L c-Myc preferentially forms an active complex with p300 rather than a repressive complex containing HDAC1 and DNMT1 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, MLL fusion protein in AML |
| + |
MYC | up-regulates quantity by expression
transcriptional regulation
|
CCND1 |
0.51 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-102731 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12835716 |
C-myc directly activates transcription of cyclin d1, cyclin d2 and cdk4, and leads to cdk 4/6 activation |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, DNMT3A in AML, AML_TRIPLETS, Triple mutant AML |
| + |
MYC | up-regulates quantity
transcriptional regulation
|
LDHA |
0.575 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259367 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 9192621 |
Our studies have linked c-Myc to the induction of LDH-A, whose expression increases lactate production and is necessary for c-Myc-mediated transformation |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
ESR1 |
transcriptional regulation
|
MYC |
0.721 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253941 |
|
|
Homo sapiens |
Breast Cancer Cell Line |
| pmid |
sentence |
| 11517191 |
ER beta and ER alpha induced the expression of several endogenous genes such as pS2, TGF alpha, or the cyclin kinase inhibitor p21 but, in contrast to ER alpha, ER beta was unable to regulate c-myc proto-oncogene expression |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
Gbeta | up-regulates activity
phosphorylation
|
MYC |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270030 |
|
|
in vitro |
|
| pmid |
sentence |
| 32482868 |
ERK1 phosphorylates MYC Ser62 resulting in MYC stabilization and activation |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
MYC | up-regulates quantity by expression
transcriptional regulation
|
PTBP1 |
0.449 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268689 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20010808 |
We also demonstrate that the oncogenic transcription factor c-Myc upregulates transcription of PTB, hnRNPA1 and hnRNPA2, |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
NSD3 | up-regulates activity
binding
|
MYC |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259200 |
|
|
Homo sapiens |
HEK-293T Cell |
| pmid |
sentence |
| 28205554 |
Indeed, dose-dependent TR-FRET and affinity pull-down assay confirmed the interaction of NSD3-s with MYC. Supporting functional significance of the interaction, co-expression of NSD3-s, but not the MYC-binding defective fragment of NSD3-s (1–347), stabilized MYC protein and increased MYC transcriptional activity as revealed by a MYC-driven reporter assay. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SKP2 | down-regulates quantity
ubiquitination
|
MYC |
0.729 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-243548 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20852628 |
The F-box protein Skp2 mediates c-Myc ubiquitylation by binding to the MB2 domain |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PRDM1 | down-regulates quantity by repression
transcriptional regulation
|
MYC |
0.447 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253828 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12032779 |
Several different transcription factors have been implicated in the down-regulation of c-myc expression during differentiation, including C/EBPalpha, CTCF, BLIMP-1, and RFX1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
STAT3 | up-regulates quantity by expression
|
MYC |
0.747 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255413 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 21408055 |
Additionally, cMyc, a STAT3 downstream gene, was significantly up-regulated in SCs at T24 versus PRE [...]An increase in the number of cMyc+ SCs indicated that human SCs were induced to proliferate under the control of STAT3 signaling. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Tissue: |
Skeletal Muscle |
| Pathways: | Acute Myeloid Leukemia, KIT in AML, EGFR Signaling, FLT3-ITD signaling, Rhabdomyosarcoma |
| + |
MYC | down-regulates quantity by repression
transcriptional regulation
|
CDKN1A |
0.774 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267574 |
|
|
Homo sapiens |
Lymphoma Cell |
| pmid |
sentence |
| 20551174 |
In tissue culture, ectopic expression of Myc suppresses the cell cycle arrest that occurs in response to several anti-mitogenic signals such as transforming growth factor β (TGFβ), since Myc represses expression of the cyclin-dependent kinase inhibitors (CKIs) p15ink4b, p21cip1, and p57kip2 via interaction with Miz1 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, FLT3-ITD in AML, FLT3-ITD signaling, Cell cycle: G1/S phase transition, Cell cycle: G2/M phase transition, Rhabdomyosarcoma |
| + |
MYC | up-regulates quantity by expression
transcriptional regulation
|
CCNA2 |
0.427 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-102728 |
|
|
Homo sapiens |
Leukemia Cell |
| pmid |
sentence |
| 12835716 |
These results suggest that e2f1 and cyclin a2 may be induced by c-myc to mediate the onset of mammary cancer, whereas overexpression of cyclins d1 and e may occur later to facilitate tumor progression. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MYC | up-regulates quantity by expression
transcriptional regulation
|
VEGFA |
0.473 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259369 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 12368264 |
These defects are intrinsic to c-Myc, and are in part associated with a requirement for c-Myc for the expression of vascular endothelial growth factor (VEGF), as VEGF can partially rescue these defects. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | NOTCH Signaling |
| + |
ADSL | up-regulates quantity by expression
|
MYC |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-266614 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 31729379 |
An integrated transcriptomics and metabolomics analysis reveals that ADSL activates the oncogenic cMYC pathway by regulating cMYC protein level via a mechanism requiring ADSL proline 24 hydroxylation. ADSL regulates cMYC protein level through adenosine levels |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Nucleotide Biosynthesis |
| + |
NDN | up-regulates quantity by expression
transcriptional regulation
|
MYC |
0.268 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253381 |
|
|
Mus musculus |
Kidney |
| pmid |
sentence |
| 24349431 |
Deletion mapping demonstrated that the C-terminus of cystin and both termini of necdin are required for their mutual interaction. Speculating that these two proteins may function to regulate gene expression, we developed a luciferase reporter assay and observed that necdin strongly activated the Myc P1 promoter, and cystin did so more modestly. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
MYC | up-regulates quantity by expression
transcriptional regulation
|
ST3GAL4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253959 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22547830 |
We provide evidence that ST3GAL1/3/4 and FUT3 are transcriptionally up-regulated by c-Myc with probable involvement of Ser62 phosphorylation, and that FUT2 is transcriptionally down-regulated through the attenuation of CDX2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MYC | up-regulates quantity by expression
transcriptional regulation
|
USP22 |
0.506 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261560 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 26049753 |
USP22 expression was regulated by c-MYC and contributed to c-MYC mediated reduction in SIRT1 polyubiquitination and degradation. USP22 directly interacted with and removing polyubiquitin chains from SIRT1 to increase SIRT1 protein stabilization and expression. These results support a role for USP22 in MYC-mediated increase in SIRT1 protein stabilization, and indicate that FLT3-ITD, c-MYC and USP22 form an oncogenic network that enhances SIRT1 expression and activity in leukemic cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, FLT3-ITD in AML |
| + |
MYC | up-regulates quantity by expression
transcriptional regulation
|
UBTF |
0.363 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-269644 |
|
|
Homo sapiens |
Granulocyte |
| pmid |
sentence |
| 15282543 |
MAD1 and c-MYC regulate UBF and rDNA transcription during granulocyte differentiation|MAD1 repressed and c-MYC activated rDNA transcription in nuclear run-on assays. Repression of rDNA transcription by MAD1 was associated with its ability to interact directly with the promoter of upstream binding factor (UBF), an rDNA regulatory factor. Conversely, c-MYC activated transcription from the UBF promoter. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, MLL fusion protein in AML |
| + |
HLX | down-regulates quantity by repression
transcriptional regulation
|
MYC |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261624 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20008130 |
In this study, we have identified cell cycle regulatory genes as downstream targets of the homeobox gene HLX in cultured trophoblast cells, namely RB1, MYC, EGR1, CDKN1C, ELK1, CCNB1, and JUN. RB1 and MYC mRNA expression was increased with HLX inactivation, whereas EGR1, CDKN1C, ELK1, CCNB1, and JUN mRNA expression was decreased compared with mock-transfected control cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MYC | up-regulates quantity by expression
transcriptional regulation
|
DHODH |
0.353 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267382 |
|
|
Homo sapiens |
P493-6 Cell |
| pmid |
sentence |
| 18628958 |
PPAT, catalyzing the first step of purine synthesis, and DHODH, an enzyme generating uridine in the middle of the pyrimidine synthesis pathway, were validated as direct c-MYC target genes by all criteria. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Nucleotide Biosynthesis |
| + |
MYC | up-regulates quantity by expression
transcriptional regulation
|
SHMT1 |
0.28 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267379 |
|
|
Homo sapiens |
P493-6 Cell |
| pmid |
sentence |
| 18628958 |
Myc regulates the de novo purine and pyrimidine synthetic genes in multiple biological systems. Intriguingly, MYC was found to directly activate the expression of SHMT1, and SHMT2, which are enzymes involved in single carbon metabolism and are essential for dNTP synthesis |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MYC | up-regulates quantity by expression
transcriptional regulation
|
HNRNPA1 |
0.468 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268690 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 20010808 |
We also demonstrate that the oncogenic transcription factor c-Myc upregulates transcription of PTB, hnRNPA1 and hnRNPA2, |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
mTORC1 | up-regulates
|
MYC |
0.349 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256172 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24856037 |
MTORC1 and mTORC2 converge on c-Myc to control metabolic reprogramming in cancer. mTORC1 and mTORC2 conspire to link growth factor receptor–PI3K signaling with c-Myc-dependent metabolic reprogramming by controlling both c-Myc levels and activity |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | EGFR Signaling, mTOR in cancer, WNT/FLT3 |
| + |
Enolase | down-regulates quantity by repression
transcriptional regulation
|
MYC |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-270308 |
|
|
Chlorocebus aethiops |
CV-1 Cell |
| pmid |
sentence |
| 2005901 |
This result suggests that MBP-1 in vivo acts as a sequence-specific repressor. |
|
| Publications: |
1 |
Organism: |
Chlorocebus Aethiops |
| + |
HIC1 | down-regulates activity
transcriptional regulation
|
MYC |
0.329 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254245 |
|
|
Homo sapiens |
MDA-MB-231 Cell |
| pmid |
sentence |
| 24067369 |
HIC1 suppressing the VEGF and c-Myc promoter activity and the colony formation of MDA-MB 231 cells were STAT3-dependent. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MYC | down-regulates quantity by repression
transcriptional regulation
|
CDKN2B |
0.591 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-102746 |
|
|
Homo sapiens |
Leukemia Cell |
| pmid |
sentence |
| 12835716 |
Miz1 is a zinc finger transcription factor with an n-terminal poz domain. Complexes with myc, bcl-6 or gfi-1 repress expression of genes like cdkn2b (p15(ink4)) or cdkn1a (p21(cip1)). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Cell cycle: G1/S phase transition |
| + |
MYC | up-regulates quantity by expression
transcriptional regulation
|
IMPDH1 |
0.245 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267378 |
|
|
Homo sapiens |
P493-6 Cell |
| pmid |
sentence |
| 18628958 |
Here, we report that the majority of genes in human purine and pyrimidine biosynthesis pathway were induced and directly bound by c-Myc in the P493-6 human Burkitt's lymphoma model cell line. The mRNA levels of IMPDH1 and IMPDH2, the rate-limiting enzyme in purine de novo synthesis, increased with MYC induction both in vitro and in vivo. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Nucleotide Biosynthesis |
| + |
FBXL14 | down-regulates quantity by destabilization
ubiquitination
|
MYC |
0.357 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-274125 |
|
|
Homo sapiens |
Glioma Stem Cell |
| pmid |
sentence |
| 27923907 |
In this study, we demonstrate that the deubiquitinase USP13 stabilizes c-Myc by antagonizing FBXL14-mediated ubiquitination to maintain GSC self-renewal and tumorigenic potential. USP13 was preferentially expressed in GSCs, and its depletion potently inhibited GSC proliferation and tumor growth by promoting c-Myc ubiquitination and degradation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
YY1 | down-regulates quantity by repression
transcriptional regulation
|
MYC |
0.559 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-268794 |
|
|
Mus musculus |
NIH-3T3 Cell |
| pmid |
sentence |
| 8266081 |
Inhibition of transcriptional regulator Yin-Yang-1 by association with c-Myc.Yin-Yang-1 (YY1) regulates the transcription of many genes, including the oncogenes c-fos and c-myc. Depending on the context, YY1 acts as a transcriptional repressor, a transcriptional activator, or a transcriptional initiator. In cotransfections, c-Myc inhibits both the repressor and the activator functions of YY1, which suggests that one way c-Myc acts is by modulating the activity of YY1. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | NOTCH Signaling |
| + |
MYC | up-regulates quantity by expression
transcriptional regulation
|
TYMS |
0.344 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267374 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18677108 |
Analysis of in vivo C-MYC interactions with TS, IMPDH2 and PRPS2 genes confirmed that they are direct C-MYC targets. C-MYC depletion did not significantly affect levels of E2F1 protein reported to regulate expression of many S-phase specific genes, but resulted in the repression of several genes encoding enzymes rate-limiting for dNTP metabolism. These included thymidylate synthase (TS), inosine monophosphate dehydrogenase 2 (IMPDH2) and phosphoribosyl pyrophosphate synthetase 2 (PRPS2). C-MYC depletion also resulted in reduction in the amounts of deoxyribonucleoside triphosphates (dNTPs) and inhibition of proliferation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MYC | up-regulates quantity
transcriptional regulation
|
PFKM |
0.334 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259988 |
|
|
Rattus norvegicus |
|
| pmid |
sentence |
| 10823814 |
C-Myc directly transactivates genes encoding GLUT1, phosphofructokinase, and enolase and increases glucose uptake in Rat1 fibroblasts. Nuclear run-on studies confirmed that the GLUT1 transcriptional rate is elevated by c-Myc. Our findings suggest that overexpression of the c-Myc oncoprotein deregulates glycolysis through the activation of several components of the glucose metabolic pathway. |
|
| Publications: |
1 |
Organism: |
Rattus Norvegicus |
| + |
SMAD4 | down-regulates quantity by repression
transcriptional regulation
|
MYC |
0.63 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251493 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11689553 |
Down-regulation of c-Myc is a critical event for growth inhibition induced by transforming growth factor-β (TGF-β) and is frequently impaired in cancer cells. We determined a Smad-responsive element in the c-mycpromoter. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Colorectal Carcinoma, Hepatocellular Tumor |
| + |
MYC | down-regulates quantity by repression
transcriptional regulation
|
HLA-G |
0.263 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254607 |
|
|
Homo sapiens |
Melanoma Cell |
| pmid |
sentence |
| 8206526 |
In melanoma, HLA class I expression is suppressed by overexpression of the c-myc oncogene. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MYC | down-regulates quantity by repression
transcriptional regulation
|
ITGA7 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-241769 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 14525975 |
This report provides evidence that alpha7 gene expression during muscle differentiation is regulated by the c-Myc transcription factor. In myoblasts, alpha7 is expressed at basal levels, but following conversion to myotubes the expression of the integrin is strongly elevated. The increased alpha7 mRNA and protein levels following myogenic differentiation are inversely correlated with c-Myc expression. Transfection of myoblasts with the c-Myc transcription factor down-regulated alpha7 expression |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
MYCBP2 | down-regulates quantity by destabilization
ubiquitination
|
MYC |
0.423 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-267147 |
|
|
Homo sapiens |
LNCaP Cell |
| pmid |
sentence |
| 32814769 |
We identified several E3 ligases as strong candidates responsible for AR and MYC protein loss as HECTD4, MYCBP2, and TRIM49. HECTD4 and MYCBP2 target AR and MYC for degradation while TRIM49 appears to promote AR and MYC stability. We have shown that these E3 ligases in turn are directly regulated by MYC. MYC in turn represses the expression of ubiquitin ligases, HECTD4 and MYCBP2 that promote AR and MYC protein degradation, further suppressing MYC and AR in a feed forward loop. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TCF4 | up-regulates quantity by expression
transcriptional regulation
|
MYC |
0.379 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253324 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 18852287 |
Association of c-Jun, β-catenin, and TCF4 specifically with the downstream enhancer underlies mitogen stimulation of c-Myc transcription. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Hepatocellular Tumor, WNT/FLT3 |
| + |
MYC | up-regulates quantity by expression
transcriptional regulation
|
CDK6 |
0.464 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-102737 |
|
|
Homo sapiens |
Leukemia Cell |
| pmid |
sentence |
| 12835716 |
The degradation of c-myc protein decreases the expression of the cell cycle regulators cdk4 and cdk6, which reversibly slows down the cell cycle. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia |
| + |
MYC | down-regulates quantity by repression
transcriptional regulation
|
HLA-B |
0.268 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254606 |
|
|
Homo sapiens |
Melanoma Cell |
| pmid |
sentence |
| 8206526 |
In melanoma, HLA class I expression is suppressed by overexpression of the c-myc oncogene. We show here that transcription of the HLA-B locus, which is mainly affected by c-Myc, is downmodulated at the level of initiation of transcription. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EGFR | up-regulates activity
|
MYC |
0.479 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252092 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 26592448 |
Instead our data provide novel evidence that EGFR signaling is needed to activate the oncogenic and pro-proliferative transcription factor c-MYC |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Acute Myeloid Leukemia, EGFR Signaling, FLT3-ITD in AML, Hepatocellular Tumor |
| + |
NOTCH1 | up-regulates quantity by expression
transcriptional regulation
|
MYC |
0.661 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-147944 |
|
|
Homo sapiens |
T-lymphocyte, Leukemia Cell, Lymphoma Cell |
| pmid |
sentence |
| 16847353 |
We identified c-myc as a direct target of notch1 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, FLT3-ITD in AML, FLT3-ITD signaling, NOTCH Signaling |
| + |
MYC | up-regulates quantity by expression
transcriptional regulation
|
BCR-ABL |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-272143 |
|
|
Homo sapiens |
K-562 Cell, LAMA-84 Cell |
| pmid |
sentence |
| 26179066 |
In the present study we demonstrate that MYC and its partner MAX bind to the BCR promoter, leading to up-regulation of BCR and BCR/ABL1 at both transcriptional and protein levels.|Here we describe a regulatory pathway modulating BCR and BCR/ABL1 expression, showing that the BCR promoter is under the transcriptional control of the MYC/MAX heterodimer. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, BCR-ABL in AML |
| + |
MYC | up-regulates quantity by expression
transcriptional regulation
|
MYCT1 |
0.303 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261736 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 11909865 |
MT-MC1 is a widely expressed nuclear protein whose overexpression, unlike that of c-Myc targets reported previously, recapitulates multiple c-Myc phenotypes. These include promotion of apoptosis, alteration of morphology, enhancement of anchorage-independent growth, tumorigenic conversion, promotion of genomic instability, and inhibition of hematopoietic differentiation. The MT-MC1 promoter is a direct c-Myc target; it contains two consensus E-box elements, both of which bind c-Myc. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
MYC | down-regulates quantity by repression
transcriptional regulation
|
PRODH |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254608 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22615405 |
MYC not only inhibited POX/PRODH, but also markedly increased the enzymes of proline biosynthesis from glutamine, including P5C synthase and P5C reductase 1. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
SWI/SNF complex | down-regulates quantity by repression
transcriptional regulation
|
MYC |
0.407 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256292 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 16452181 |
C-myc is a direct target of SWI/SNF complex–dependent promoter repression. These results indicate that repression of c-myc is indeed dependent on the activity of SWI/SNF–related complexes and specifically on complexes that contain ARID1A. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
MYC | up-regulates quantity by expression
transcriptional regulation
|
ST3GAL1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253961 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22547830 |
We provide evidence that ST3GAL1/3/4 and FUT3 are transcriptionally up-regulated by c-Myc with probable involvement of Ser62 phosphorylation, and that FUT2 is transcriptionally down-regulated through the attenuation of CDX2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
FBXW7 | down-regulates quantity by destabilization
ubiquitination
|
MYC |
0.756 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249638 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 15103331 |
We now show that the F-box protein Fbw7 interacts with and thereby destabilizes c-Myc in a manner dependent on phosphorylation of MB1 |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, DNMT3A in AML, NPM1 in AML, AML_TRIPLETS, Triple mutant AML, NPM1_new |
| + |
GPAA1 | up-regulates quantity by expression
transcriptional regulation
|
MYC |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261240 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 32432756 |
GPAA1 may contribute to the malignant progression of childhood ALL via activating c-myc. Luciferase reporter gene assay demonstrated that overexpression of c-myc remarkably attenuated the Luciferase activity of the wild-type GPAA1 vector without attenuating that of the mutant vector or empty vector, further demonstrating that GPAA1 can be targeted by c-myc. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
MYC | up-regulates quantity by expression
transcriptional regulation
|
FUT3 |
0.256 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254612 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 22547830 |
We provide evidence that ST3GAL1/3/4 and FUT3 are transcriptionally up-regulated by c-Myc with probable involvement of Ser62 phosphorylation, and that FUT2 is transcriptionally down-regulated through the attenuation of CDX2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
mTORC2 | up-regulates
|
MYC |
0.36 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-256171 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 24856037 |
MTORC1 and mTORC2 converge on c-Myc to control metabolic reprogramming in cancer. mTORC1 and mTORC2 conspire to link growth factor receptor–PI3K signaling with c-Myc-dependent metabolic reprogramming by controlling both c-Myc levels and activity |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | FLT3-ITD signaling, mTOR in cancer |
| + |
PIM1 | up-regulates activity
phosphorylation
|
MYC |
0.688 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-261557 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 25280219 |
FLT3-ITD kinase may regulate c-MYC through STAT5-induced enhancement of PIM kinases (Choudhary et al., 2009), which can modulate c-MYC stability and activity via phosphorylation (van der Lugt et al., 1995s). This is supported by the observation that FLT3-ITD CD34+ cells showed higher PIM activity compared to cells expressing FLT3-WT, indicated by increased expression of the PIM targets including p-BAD (Ser112), p-4EBP1 (Thr37/46), and p-c-MYC (Ser62) (Figure 6C); and by the observation that siRNA-mediated inhibition of PIM1, but not PIM2, expression resulted in significantly decreased p-c-MYC (Ser62), c-MYC, and SIRT1 expression in MV4-11 cells |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| Pathways: | Acute Myeloid Leukemia, FLT3 in AML, FLT3-ITD in AML, FLT3-ITD signaling |
| + |
SARS1 | down-regulates activity
binding
|
MYC |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259368 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 24940000 |
Using in vitro, cell and animal experiments, we show here that SerRS intervenes by antagonizing c-Myc, the major transcription factor promoting VEGFA expression, through a tandem mechanism. First, by direct head-to-head competition, nuclear-localized SerRS blocks c-Myc from binding to the VEGFA promoter. Second, DNA-bound SerRS recruits the SIRT2 histone deacetylase to erase prior c-Myc-promoted histone acetylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
miR-155 | down-regulates quantity by repression
post transcriptional regulation
|
MYC |
0.4 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-255721 |
|
|
Mus musculus |
|
| pmid |
sentence |
| 19933931 |
On the basis of bioinformatics tools, biochemical assays, and in vivo models, we demonstrate that (1) insulin-like growth factor-1 (IGF-1) and IGF-1 receptor are targets of miR-1 |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| Pathways: | Acute Myeloid Leukemia, miRNA in AML |
| + |
MYC | down-regulates quantity by repression
transcriptional regulation
|
HLA-A |
0.272 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254603 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8206526 |
In melanoma, HLA class I expression is suppressed by overexpression of the c-myc oncogene. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
MYC
- 
- 