Relation Results

Summary

Name SFPQ
Full Name Splicing factor, proline- and glutamine-rich
Synonyms 100 kDa DNA-pairing protein, hPOMp100, DNA-binding p52/p100 complex, 100 kDa subunit, Polypyrimidine tract-binding protein-associated-splicing factor, PSF, PTB-associated-splicing factor | PSF
Primary ID P23246
Links - -
Type protein
Relations 10
Function DNA- and RNA binding protein, involved in several nuclear processes. Essential pre-mRNA splicing factor required early in spliceosome formation and fo ...
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Type: Score: Layout: SPV 
0.20.3510.20.4570.4460.6990.20.38GSK3ASFPQGSK3BALKLMX1B/SFPQ/PSPC1 complexTHRAP3NONO/SFPQTHTOP1

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ GSK3Adown-regulates img/direct_inhibition.png phosphorylation SFPQ 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-168382 Thr687 PRGMGPGtPAGYGRG Homo sapiens
pmid sentence
Here we demonstrate that in resting tcells psf is directly phosphorylated by gsk3, thus promoting interaction of psf with trap150, which prevents psf from binding cd45 pre-mrna. Upon tcell activation, reduced gsk3 activity leads to reduced psf phosphorylation, releasing psf from trap150 and allowing it to bind cd45 splicing regulatory elements and repress exon inclusion.
Identifier Residue Sequence Organism Cell Line
SIGNOR-168385 Homo sapiens
pmid sentence
Psf is directly phosphorylated by gsk3, thus promoting interaction of psf with trap150, which prevents psf from binding cd45 pre-mrna. / threonine phosphorylation of psf by gsk3 primarily occurs on residue t687
Publications: 2 Organism: Homo Sapiens
+ GSK3Bdown-regulates img/direct_inhibition.png phosphorylation SFPQ 0.351
Identifier Residue Sequence Organism Cell Line
SIGNOR-168389 Thr687 PRGMGPGtPAGYGRG Homo sapiens
pmid sentence
We conclude that t687 is the primary site of threonine phosphorylation in psf. Gsk3 directly phosphorylates the splicing regulatory protein psf. In this phosphorylated form, psf is sequestered in a complex with trap150, precluding it from binding the ess1 sequence in cd45 alternatively spliced exons. Upon t?_Cell stimulation, reduced gsk3 activity leads to reduced psf phosphorylation, thereby releasing psf from trap150 and allowing it to participate in activation-induced cd45 exon skipping
Identifier Residue Sequence Organism Cell Line
SIGNOR-168392 Homo sapiens
pmid sentence
Psf is directly phosphorylated by gsk3, thus promoting interaction of psf with trap150, which prevents psf from binding cd45 pre-mrna. / threonine phosphorylation of psf by gsk3 primarily occurs on residue t687
Publications: 2 Organism: Homo Sapiens
+ ALKdown-regulates img/direct_inhibition.png phosphorylation SFPQ 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-155298 Tyr293 RRPGEKTyTQRCRLF Homo sapiens Lymphoma Cell
pmid sentence
Furthermore, psf was shown to be a direct substrate of purified alk kinase domain in vitro, and psf tyr293 was identified as the site of phosphorylation. Psf phosphorylation also increased its binding to rna and decreased the psf-mediated suppression of gage6 expression.
Publications: 1 Organism: Homo Sapiens
+ SFPQform complex img/form-complex.png binding LMX1B/SFPQ/PSPC1 complex 0.457
Identifier Residue Sequence Organism Cell Line
SIGNOR-223970 Mus musculus
pmid sentence
LMX1B is part of a transcriptional complex with PSPC1 and PSF. This complex was observed in vitro and in vivo.
Publications: 1 Organism: Mus Musculus
+ THRAP3down-regulates img/direct_inhibition.png binding SFPQ 0.446
Identifier Residue Sequence Organism Cell Line
SIGNOR-168441 Homo sapiens
pmid sentence
Here we demonstrate that in resting tcells psf is directly phosphorylated by gsk3, thus promoting interaction of psf with trap150, which prevents psf from binding cd45 pre-mrna. Upon tcell activation, reduced gsk3 activity leads to reduced psf phosphorylation, releasing psf from trap150 and allowing it to bind cd45 splicing regulatory elements and repress exon inclusion.
Publications: 1 Organism: Homo Sapiens
+ SFPQform complex img/form-complex.png binding NONO/SFPQ 0.699
Identifier Residue Sequence Organism Cell Line
SIGNOR-60560 Homo sapiens
pmid sentence
We show that the psf/p54 dimer has pronounced stimulatory effect on dna catalysis by topoisomerase i
Publications: 1 Organism: Homo Sapiens
+ SFPQdown-regulates quantity by repression img/direct_inhibition.png transcriptional regulation TH 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-271697
pmid sentence
It has been reported that DJ-1 is a neuroprotective transcriptional co-activator that sequesters a transcriptional co-repressor polypyrimidine tract-binding protein-associated splicing factor (PSF) from the TH gene promoter.
Publications: 1
+ SFPQup-regulates img/direct-activation.png binding TOP1 0.38
Identifier Residue Sequence Organism Cell Line
SIGNOR-60563 Homo sapiens
pmid sentence
We show that the psf/p54 dimer has pronounced stimulatory effect on dna catalysis by topoisomerase i
Publications: 1 Organism: Homo Sapiens
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