| + |
CyclinA2/CDK2 | up-regulates activity 
phosphorylation
|
RRM1 |
0.327 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277522 |
Ser559 |
PYETYEGsPVSKGIL |
Homo sapiens |
|
| pmid |
sentence |
| 32712628 |
Here, we report that RRM1 is phosphorylated at Ser 559 by CDK2/cyclin A during S/G2 phase. And this S559 phosphorylation of RRM1enhances RNR enzymatic activity and is required for maintaining sufficient dNTPs during normal DNA replication. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
mTORC2 | up-regulates activity
phosphorylation
|
RRM1 |
0.308 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277566 |
Ser631 |
IYTRRVLsGEFQIVN |
Homo sapiens |
NCI-H1299 Cell |
| pmid |
sentence |
| 34126361 |
Mechanistically, mTORC2 directly interacted and phosphorylated RNR large subunit RRM1 at Ser 631. Ser631 phosphorylation of RRM1 enhanced its interaction with small subunit RRM2 to maintain sufficient RNR enzymatic activity for efficient DNA replication. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RRM2B | up-regulates activity
binding
|
RRM1 |
0.932 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259366 |
|
|
Homo sapiens |
PC-3 Cell |
| pmid |
sentence |
| 14583450 |
Taken together, we conclude that UV-induced activation of p53R2 transcription and binding of p53R2 to hRRM1 to form RR holoenzyme are impaired in the p53-mutant cell line PC3. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TFDP1 | up-regulates quantity by expression 
transcriptional regulation
|
RRM1 |
0.287 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253866 |
|
|
Homo sapiens |
HEP-3B Cell |
| pmid |
sentence |
| 14618416 |
To assess transactivating activity of E2F1/DP-1, we also analyzed expression of ten putative transcriptional targets of this complex in HCCs. Expression levels of TFDP1 and E2F1 correlated with those of seven transcriptional targets ( TYMS, DHFR, PCNA, RRM1, CCNE1, CDC2, and MYBL2) that play important roles in the G1/S transition, and down-regulation of TFDP1 inhibited growth of Hep3B cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
(2R,3S,4S,5R)-2-(6-amino-2-fluoro-9-purinyl)-5-(hydroxymethyl)oxolane-3,4-diol | down-regulates activity 
chemical inhibition
|
RRM1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258404 |
|
|
in vitro |
|
| pmid |
sentence |
| 7048062 |
In vitro biological activity of 9-beta-D-arabinofuranosyl-2-fluoroadenine and the biochemical actions of its triphosphate on DNA polymerases and ribonucleotide reductase from HeLa cells. 2-F-araATP was a potent inhibitor of ribonucleotide reductase |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
RRM1 | form complex 
binding
|
Ribonucleotide reductase |
0.93 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-259363 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 14583450 |
Ribonucleotide reductase (RR) is responsible for the de novo conversion of the ribonucleoside diphosphates to deoxyribonucleoside diphosphates, which are essential for DNA synthesis and repair.RR consists of two subunits, hRRM1 and hRRM2. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
E2F1 | up-regulates quantity by expression
transcriptional regulation
|
RRM1 |
0.304 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-253852 |
|
|
Homo sapiens |
HEP-3B Cell |
| pmid |
sentence |
| 14618416 |
To assess transactivating activity of E2F1/DP-1, we also analyzed expression of ten putative transcriptional targets of this complex in HCCs. Expression levels of TFDP1 and E2F1 correlated with those of seven transcriptional targets ( TYMS, DHFR, PCNA, RRM1, CCNE1, CDC2, and MYBL2) that play important roles in the G1/S transition, and down-regulation of TFDP1 inhibited growth of Hep3B cells. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
gemcitabine | down-regulates activity
chemical inhibition
|
RRM1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258386 |
|
|
in vitro |
|
| pmid |
sentence |
| 2233693 |
Direct assays of partially purified ribonucleoside diphosphate reductase (EC 1.17.4.1) demonstrated 50% inhibition by 4 microM dFdC 5'-diphosphate; dFdC 5'-triphosphate was much less inhibitory. We conclude that dFdC 5'-diphosphate acts as an inhibitor of ribonucleoside diphosphate reductase. |
|
| Publications: |
1 |
Organism: |
In Vitro |
| + |
clofarabine | down-regulates activity
chemical inhibition
|
RRM1 |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-258357 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 1707752 |
Effects of 2-Chloro-9-(2-deoxy-2-fluoro-β-d-arabinofuranosyl)adenine on K562 Cellular Metabolism and the Inhibition of Human Ribonucleotide Reductase and DNA Polymerases by Its 5′-Triphosphate |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
RRM1
- 
- 