Summary

Name CXCR1
Full Name C-X-C chemokine receptor type 1
Synonyms CXC-R1, CXCR-1, CDw128a, High affinity interleukin-8 receptor A, IL-8R A, IL-8 receptor type 1 | CMKAR1, IL8RA
Primary ID P25024
Links - -
Type protein
Relations 2
Function Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity.

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Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png binding CXCR1 0.334
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding CXCR1 0.773
Publications: 1 Organism: Homo Sapiens