| + |
CD70 | up-regulates 
binding
|
CD27 |
0.765 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-93435 |
|
|
Homo sapiens |
B-lymphocyte |
| pmid |
sentence |
| 12324477 |
The molecule defining the cd70 ag is identical to the recently defined ligand for cd27. Bioassays demonstrated that the cd70 cdna clone expressed in african green monkey kidney cells would induce the proliferation of pha-costimulated t cells. Ramos cells were mixed with increasing numbers of transfected cells that expressed cd70 (cd27l) or cd154 (cd40l), both of which are expressed by activated t cells, in the presence of anti-igm ab. Cd27 ligation as well as cd40 ligation inhibited bcr-mediated apoptosis in a dose-dependent manner. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-36357 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 8120384 |
The molecule defining the cd70 ag is identical to the recently defined ligand for cd27. Bioassays demonstrated that the cd70 cdna clone expressed in african green monkey kidney cells would induce the proliferation of pha-costimulated t cells. Ramos cells were mixed with increasing numbers of transfected cells that expressed cd70 (cd27l) or cd154 (cd40l), both of which are expressed by activated t cells, in the presence of anti-igm ab. Cd27 ligation as well as cd40 ligation inhibited bcr-mediated apoptosis in a dose-dependent manner. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| Tissue: |
Skeletal Muscle, Brain, Heart, Hindbrain |
| + |
CD27 | up-regulates quantity by expression 
transcriptional regulation
|
BCL2L1 |
0.328 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-93320 |
|
|
Homo sapiens |
B-lymphocyte |
| pmid |
sentence |
| 12324477 |
Cd40 ligation up-regulated bcl-2 and bcl-xl as much as 9.7- (p < 0.01) and 6.8-fold (p < 0.01), respectively (fig. 2, b and c). Under similar conditions, cd27 ligation also up-regulated bcl-2 and bcl-xl as much as 5.0- (p < 0.01) and 3.9-fold (p < 0.01), respectively. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CD27 | down-regulates quantity by repression 
transcriptional regulation
|
BIK |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-93323 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12324477 |
Bik expression was weakly but significantly down-regulated by cd27 but up-regulated by cd40. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CD27 | up-regulates quantity by expression
transcriptional regulation
|
BCL2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-93317 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 12324477 |
Cd40 ligation up-regulated bcl-2 and bcl-xl as much as 9.7- (p < 0.01) and 6.8-fold (p < 0.01), respectively (fig. 2, b and c). Under similar conditions, cd27 ligation also up-regulated bcl-2 and bcl-xl as much as 5.0- (p < 0.01) and 3.9-fold (p < 0.01), respectively. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
CD27
- 
- 