| + |
IL3RA | up-regulates 
|
STAT5A |
0.556 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-134862 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15795318 |
We previously demonstrated that integrin-dependent adhesion activates stat5a, a well known target of il-3-mediated signaling |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL3RA | up-regulates 
binding
|
JAK2 |
0.598 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-134859 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 15795318 |
Indeed, only upon fibronectin adhesion is janus kinase 2 (jak2) recruited to the beta1 integrin-il-3r complex and triggers il-3r beta common phosphorylation, leading to the formation of docking sites for activated stat5a. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
IL3 | up-regulates
binding
|
IL3RA |
0.884 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-19538 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 1465408 |
These results show the generation of an il-3 analog with increased biological and binding activities and support a model where the c terminus of il-3 interacts with the alpha chain of the il-3 receptor, making this region a useful focus for the development of more potent il-3 agonists or antagonists |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-111404 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11700046 |
The results demonstrate that both the association and dissociation rates for the binding of il-3 to the il-3ralpha are altered by truncation and by amino acid substitution at individual sites. Intracellular signaling studies using k116w and e43n demonstrate that differences in the il-3alpha binding characteristics are reflected in magnitude and kinetics of stat5 phosphorylation. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
3.0
IL3RA
- 
- 