| + |
MARK1 | down-regulates activity 
phosphorylation
|
MAP4 |
0.449 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250169 |
Ser1073 |
KAQAKVGsLDNVGHL |
in vitro |
|
| pmid |
sentence |
| 8631898 |
Here we show that p110mark phosphorylates analogous KXGS sites in the microtubule binding domains of the neuronal MAP2 and the ubiquitous MAP4. Phosphorylation in vitro leads to the dissociation of MAP2 and MAP4 from microtubules and to a pronounced increase in dynamic instability. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250170 |
Ser928 |
SRLATNTsAPDLKNV |
in vitro |
|
| pmid |
sentence |
| 8631898 |
Here we show that p110mark phosphorylates analogous KXGS sites in the microtubule binding domains of the neuronal MAP2 and the ubiquitous MAP4. Phosphorylation in vitro leads to the dissociation of MAP2 and MAP4 from microtubules and to a pronounced increase in dynamic instability. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250171 |
Ser941 |
NVRSKVGsTENIKHQ |
in vitro |
|
| pmid |
sentence |
| 8631898 |
Here we show that p110mark phosphorylates analogous KXGS sites in the microtubule binding domains of the neuronal MAP2 and the ubiquitous MAP4. Phosphorylation in vitro leads to the dissociation of MAP2 and MAP4 from microtubules and to a pronounced increase in dynamic instability. |
|
| Publications: |
3 |
Organism: |
In Vitro |
| + |
CDK1 | down-regulates
phosphorylation
|
MAP4 |
0.512 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-53735 |
Ser696 |
PNKELPPsPEKKTKP |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 9398320 |
Map4 is phosphorylated by cdc2 kinase in mitotic hela/ phosphorylation by cdc2 kinase decreased the microtubule-stabilizing ability of map4, suggesting that there are critical phosphorylation sites among the five major cdc2 kinase-dependent phosphorylation sites [spots 4 (ser-696), 5, 6, 9, and 10 (ser-787)]. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-53739 |
Ser787 |
KAPEKRAsPSKPASA |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 9398320 |
Map4 is phosphorylated by cdc2 kinase in mitotic hela/ phosphorylation by cdc2 kinase decreased the microtubule-stabilizing ability of map4, suggesting that there are critical phosphorylation sites among the five major cdc2 kinase-dependent phosphorylation sites [spots 4 (ser-696), 5, 6, 9, and 10 (ser-787)]. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-77087 |
Ser787 |
KAPEKRAsPSKPASA |
Homo sapiens |
|
| pmid |
sentence |
| 10791892 |
Ser787 in the proline-rich region of human map4 is a critical phosphorylation site that reduces its activity to promote tubulin polymerization. Phosphorylation on ser-787 negatively regulates map4 activity to promote microtubule assembly. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
CDK1 |
phosphorylation
|
MAP4 |
0.512 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277461 |
Ser696 |
PNKELPPsPEKKTKP |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 10791892 |
We have shown that MAP4 is phosphorylated in vivo in mitotic HeLa cells at eight sites. Five of these were phosphorylated by p34cdc2 kinase. Two of the five p34cdc2 kinase phosphorylation sites were shown to be Ser696 and Ser787 in the proline-rich region |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDK1 | down-regulates activity
phosphorylation
|
MAP4 |
0.512 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277459 |
Ser787 |
KAPEKRAsPSKPASA |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 10791892 |
We have shown that MAP4 is phosphorylated in vivo in mitotic HeLa cells at eight sites. Five of these were phosphorylated by p34cdc2 kinase. Two of the five p34cdc2 kinase phosphorylation sites were shown to be Ser696 and Ser787 in the proline-rich region. Mutation of Ser787 to Glu strikingly reduced the MAP4's MT-polymerization activity, while Glu-mutation at Ser696 did not. These results suggest that Ser787 could be the critical phosphorylation site causing MTs to be dynamic at mitosis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TTK | down-regulates quantity by destabilization
phosphorylation
|
MAP4 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277458 |
Ser928 |
SRLATNTsAPDLKNV |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 31253867 |
We further uncovered that Mps1 is a kinase of MAP4, and E7-MAP4 binding blocks Mps1 phosphorylation of MAP4, thereby interrupting phosphorylation-dependent MAP4 degradation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277462 |
Thr927 |
LSRLATNtSAPDLKN |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 31253867 |
We further uncovered that Mps1 is a kinase of MAP4, and E7-MAP4 binding blocks Mps1 phosphorylation of MAP4, thereby interrupting phosphorylation-dependent MAP4 degradation. |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
MAP4 | up-regulates 
|
Microtubule_polimerization |
0.7 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277460 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 10791892 |
We have shown that MAP4 is phosphorylated in vivo in mitotic HeLa cells at eight sites. Five of these were phosphorylated by p34cdc2 kinase. Two of the five p34cdc2 kinase phosphorylation sites were shown to be Ser696 and Ser787 in the proline-rich region. Mutation of Ser787 to Glu strikingly reduced the MAP4's MT-polymerization activity, while Glu-mutation at Ser696 did not. These results suggest that Ser787 could be the critical phosphorylation site causing MTs to be dynamic at mitosis. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
MAP4
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