| + |
MARK1 | down-regulates activity 
phosphorylation
|
MAP4 |
0.428 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250169 |
Ser1073 |
KAQAKVGsLDNVGHL |
in vitro |
|
| pmid |
sentence |
| 8631898 |
Here we show that p110mark phosphorylates analogous KXGS sites in the microtubule binding domains of the neuronal MAP2 and the ubiquitous MAP4. Phosphorylation in vitro leads to the dissociation of MAP2 and MAP4 from microtubules and to a pronounced increase in dynamic instability. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250170 |
Ser928 |
SRLATNTsAPDLKNV |
in vitro |
|
| pmid |
sentence |
| 8631898 |
Here we show that p110mark phosphorylates analogous KXGS sites in the microtubule binding domains of the neuronal MAP2 and the ubiquitous MAP4. Phosphorylation in vitro leads to the dissociation of MAP2 and MAP4 from microtubules and to a pronounced increase in dynamic instability. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-250171 |
Ser941 |
NVRSKVGsTENIKHQ |
in vitro |
|
| pmid |
sentence |
| 8631898 |
Here we show that p110mark phosphorylates analogous KXGS sites in the microtubule binding domains of the neuronal MAP2 and the ubiquitous MAP4. Phosphorylation in vitro leads to the dissociation of MAP2 and MAP4 from microtubules and to a pronounced increase in dynamic instability. |
|
| Publications: |
3 |
Organism: |
In Vitro |
| + |
CDK1 | down-regulates
phosphorylation
|
MAP4 |
0.487 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-53735 |
Ser696 |
PNKELPPsPEKKTKP |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 9398320 |
Map4 is phosphorylated by cdc2 kinase in mitotic hela/ phosphorylation by cdc2 kinase decreased the microtubule-stabilizing ability of map4, suggesting that there are critical phosphorylation sites among the five major cdc2 kinase-dependent phosphorylation sites [spots 4 (ser-696), 5, 6, 9, and 10 (ser-787)]. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-77087 |
Ser787 |
KAPEKRAsPSKPASA |
Homo sapiens |
|
| pmid |
sentence |
| 10791892 |
Ser787 in the proline-rich region of human map4 is a critical phosphorylation site that reduces its activity to promote tubulin polymerization. Phosphorylation on ser-787 negatively regulates map4 activity to promote microtubule assembly. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-53739 |
Ser787 |
KAPEKRAsPSKPASA |
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 9398320 |
Map4 is phosphorylated by cdc2 kinase in mitotic hela/ phosphorylation by cdc2 kinase decreased the microtubule-stabilizing ability of map4, suggesting that there are critical phosphorylation sites among the five major cdc2 kinase-dependent phosphorylation sites [spots 4 (ser-696), 5, 6, 9, and 10 (ser-787)]. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
| + |
CDK1 |
Fatal error: Uncaught TypeError: implode(): Argument #2 ($array) must be of type ?array, string given in /home/prisca/signor/relation_result.php:2084
Stack trace:
#0 /home/prisca/signor/relation_result.php(2084): implode()
#1 {main}
thrown in /home/prisca/signor/relation_result.php on line 2084
4.0
MAP4
- 
- 