Summary

Name PSMB5
Full Name Proteasome subunit beta type-5
Synonyms Macropain epsilon chain, Multicatalytic endopeptidase complex epsilon chain, Proteasome chain 6, Proteasome epsilon chain, Proteasome subunit MB1, Proteasome subunit X | LMPX, MB1, X
Primary ID P28074
Links - -
Type protein
Relations 5
Inhibitors bortezomib; ixazomib; ixazomib citrate; carfilzomib
Function Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB5 displays a chymotrypsin-like activity.

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Relations

Regulator Mechanism target score ℹ
+ bortezomibdown-regulates activity img/direct_inhibition.png chemical inhibition PSMB5 0.8
Publications: 1 Organism: Homo Sapiens
+ ixazomibdown-regulates img/direct_inhibition.png chemical inhibition PSMB5 0.8
Publications: 1 Organism: Homo Sapiens
+ ixazomib citratedown-regulates img/direct_inhibition.png chemical inhibition PSMB5 0.8
Publications: 1 Organism: Homo Sapiens
+ carfilzomibdown-regulates activity img/direct_inhibition.png chemical inhibition PSMB5 0.8
Publications: 1 Organism: Homo Sapiens
+ PSMB5form complex img/form-complex.png binding 26S Proteasome 0.859
Publications: 1 Organism: Homo Sapiens