Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-236956 |
|
|
Mus musculus |
NIH-3T3 Cell |
pmid |
sentence |
8890171 |
We show that HMG1 interacts with proteins encoded by the HOX gene family by establishing protein-protein contacts between the HMG box domains and the HOX homeodomain. The functional role of these interactions was studied using the transcriptional activity of the human HOXD9 protein as a model. HMG1 enhances, in a dose-dependent fashion, the sequence-specific DNA binding activity in vitro, and the transcriptional activation in a co-transfection assay in vivo, of the HOXD9 protein. |
|