+ |
PCSK6 | up-regulates activity
cleavage
|
VWF |
0.298 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-260367 |
|
|
|
|
pmid |
sentence |
8218226 |
Like PACE,PACE4 was able to process pro-vWF to its mature form, and efficient cleavage required both the P4 arginine and the P2 lysine |
|
Publications: |
1 |
+ |
PCSK6 | up-regulates activity
cleavage
|
INSR |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-260366 |
|
|
Homo sapiens |
LoVo Cell |
pmid |
sentence |
25527501 |
Here we demonstrate that the two IR isoforms are similarly cleaved by furin, but when this furin-dependent maturation is inefficient, IR proforms move to the cell surface where the proprotein convertase PACE4 selectively supports IRB maturation. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |