Summary

Name CD40LG
Full Name CD40 ligand
Synonyms CD40-L, T-cell antigen Gp39, TNF-related activation protein, TRAP, Tumor necrosis factor ligand superfamily member 5 | CD40L, TNFSF5, TRAP
Primary ID P29965
Links - -
Type protein
Relations 4
Pathways NF-KB Non Canonical
Function Cytokine that acts as a ligand to CD40/TNFRSF5 (PubMed:1280226, PubMed:31331973). Costimulates T-cell proliferation and cytokine production (PubMed:8617933). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (PubMed:8617933). Induces the activation of NF-kappa-B (PubMed:15067037, PubMed:31331973). Induces the activation of kinases MAPK8 and PAK2 in T-cells (PubMed:15067037). Induces tyrosine phosphorylation of isoform 3 of CD28 (PubMed:15067037). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4 (By similarity). Involved in immunoglobulin class switching (By similarity).

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Relations

Regulator Mechanism target score ℹ
+ CD40LGdown-regulates img/indirect_inhibition.png PTPN7 0.2
Publications: 1 Organism: Homo Sapiens
+ CD40LGdown-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation IGSF6 0.332
Publications: 1 Organism: Homo Sapiens
+ CD40LGup-regulates activity img/direct-activation.png binding CD40 0.927
Publications: 2 Organism: Homo Sapiens
Pathways:NF-KB Non Canonical