3.0
Summary
| Name |  BLVRB
|
| Full Name | Flavin reductase |
| Synonyms | FR, Biliverdin reductase B, BVR-B, 1.3.1.24, Biliverdin-IX beta-reductase, Green heme-binding protein, GHBP, NADPH-dependent diaphorase, NADPH-flavin reductase, FLR | FLR |
| Primary ID | P30043 |
| Links |  -  -  |
| Type | protein |
| Relations | 2 |
| Function | Broad specificity oxidoreductase that catalyzes the NADPH-dependent reduction of a variety of flavins, such as riboflavin, FAD or FMN, biliverdins, methemoglobin and PQQ (pyrroloquinoline quinone). Contributes to heme catabolism and metabolizes linear tetrapyrroles. Can also reduce the complexed Fe(3+) iron to Fe(2+) in the presence of FMN and NADPH. In the liver, converts biliverdin to bilirubin. |
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Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | BLVRB | down-regulates quantity 
chemical modification
|
bilirubin(2-) | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Tissue: | Liver | |||
| + | BLVRB | up-regulates quantity 
chemical modification
|
biliverdin(2-) | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Tissue: | Liver | |||