| + |
phenylalanine | down-regulates activity 
chemical inhibition
|
GCHFR |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252205 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11361142 |
The enzyme activity of GTP cyclohydrolase I is controlled by a regulatory protein for this enzyme, GFRP, which is a pentamer of identical subunits. GFRP mediates feedback inhibition of GTP cyclohydrolase I activity by BH4, and the inhibition by BH4 is reversed by phenylalanine |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
sapropterin | up-regulates activity 
chemical activation
|
GCHFR |
0.8 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252204 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11361142 |
The enzyme activity of GTP cyclohydrolase I is controlled by a regulatory protein for this enzyme, GFRP, which is a pentamer of identical subunits. GFRP mediates feedback inhibition of GTP cyclohydrolase I activity by BH4, and the inhibition by BH4 is reversed by phenylalanine |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
GCHFR | down-regulates activity
binding
|
GCH1 |
0.859 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252203 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11361142 |
The enzyme activity of GTP cyclohydrolase I is controlled by a regulatory protein for this enzyme, GFRP, which is a pentamer of identical subunits. GFRP mediates feedback inhibition of GTP cyclohydrolase I activity by BH4, and the inhibition by BH4 is reversed by phenylalanine |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
GCHFR
- 
- 