| + |
CSNK2A1 | up-regulates 
phosphorylation
|
CDC27 |
0.391 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-170872 |
Ser154 |
FLWSPFEsLCEIGEK |
Homo sapiens |
|
| pmid |
sentence |
| 21209074 |
We report here that phosphorylation of cdc27, a core subunit of apc, in response to tgf- signaling can facilitate the activation of apc.we have demonstrated that casein kinase ii (ckii) is involved in the phosphorylation of cdc27 in response to tgf- signaling. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
AMPK |
phosphorylation
|
CDC27 |
0.274 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-216434 |
Ser379 |
NALPRRSsRLFTSDS |
Homo sapiens |
|
| pmid |
sentence |
| 22137581 |
Using this approach for ppp1r12c, baiap2, and cdc27, we found that mutation of a single serine to alanine (s452, s366, and s379, respectively) resulted in an almost complete loss of ampk phosphorylation in these proteins |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PRKAA2 |
phosphorylation
|
CDC27 |
0.266 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-195106 |
Ser379 |
NALPRRSsRLFTSDS |
Homo sapiens |
|
| pmid |
sentence |
| 22137581 |
Using this approach for ppp1r12c, baiap2, and cdc27, we found that mutation of a single serine to alanine (s452, s366, and s379, respectively) resulted in an almost complete loss of ampk phosphorylation in these proteins |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
CDK1 | up-regulates
phosphorylation
|
CDC27 |
0.692 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-119873 |
Ser426 |
TQPNINDsLEITKLD |
Homo sapiens |
|
| pmid |
sentence |
| 14657031 |
Apc activation is thought to depend on apc phosphorylation and cdc20 binding. We have identified 43 phospho_sites on apc of which at least 34 are mitosis specific. Of these, 32 sites are clustered in parts of apc1 and the tetratricopeptide repeat (tpr) subunits cdc27, cdc16, cdc23 and apc7. In vitro, at least 15 of the mitotic phospho_sites can be generated by cyclin_dependent kinase 1 (cdk1), and 3 by polo_like kinase 1 (plk1). Apc phosphorylation by cdk1, but not by plk1, is sufficient for increased cdc20 binding and apc activation |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-119877 |
Thr446 |
EGKISTItPQIQAFN |
Homo sapiens |
|
| pmid |
sentence |
| 14657031 |
Apc activation is thought to depend on apc phosphorylation and cdc20 binding. We have identified 43 phospho_sites on apc of which at least 34 are mitosis specific. Of these, 32 sites are clustered in parts of apc1 and the tetratricopeptide repeat (tpr) subunits cdc27, cdc16, cdc23 and apc7. In vitro, at least 15 of the mitotic phospho_sites can be generated by cyclin_dependent kinase 1 (cdk1), and 3 by polo_like kinase 1 (plk1). Apc phosphorylation by cdk1, but not by plk1, is sufficient for increased cdc20 binding and apc activation |
|
| Publications: |
2 |
Organism: |
Homo Sapiens |
| + |
CDC27 | form complex 
binding
|
APC-c |
0.885 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-252003 |
|
|
|
|
| pmid |
sentence |
| 16896351 |
The anaphase promoting complex/cyclosome (APC/C) is a ubiquitin ligase that has essential functions in and outside the eukaryotic cell cycle. It is the most complex molecular machine that is known to catalyse ubiquitylation reactions, and it contains more than a dozen subunits that assemble into a large 1.5-MDa complex. |
|
| Publications: |
1 |
3.0
CDC27
- 
- 