Relation Results

Summary

Name PRKAA2
Full Name 5'-AMP-activated protein kinase catalytic subunit alpha-2
Synonyms AMPK subunit alpha-2, Acetyl-CoA carboxylase kinase, ACACA kinase, 2.7.11.27, Hydroxymethylglutaryl-CoA reductase kinase, HMGCR kinase, 2.7.11.31 | AMPK, AMPK2
Primary ID P54646
Links - -
Type protein
Relations 58
Function Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metaboli ...
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Type: Score: Layout: SPV 
0.20.5670.4780.4070.2580.2430.6420.20.3720.4910.20.2750.20.4870.2640.3320.2610.4340.20.6860.20.690.20.2660.6110.6170.2590.2590.4910.80.3070.8950.2580.8260.80.70.3760.5390.2PRKAA2HIPK2TSC2CRTC2PRKACAIKBKBPAK2ACACBPDHA1HNF4AULK1VASPDUSP1BAIAP2EEF2KCDC27SREBF1PPP1R12CPFKFB2PLD1RPTORPROX1ACACAHAS2ATMCAMKK2STK11SRCFYNAICA-RibotideULK2PRKAG1IKK-complexAMPKmetforminSerumINSRTSC1Gbeta

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▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ PRKAA2down-regulates activity img/direct_inhibition.png phosphorylation HIPK2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-275486 Ser121 LMRRSTVsLLDTYQK
pmid sentence
AMPKalpha2-mediated inhibition of WIP1 phosphorylation by HIPK2|Site-directed mutagenesis of Thr112 and Ser114 in the N terminus, and Thr1107 in the C terminus markedly reduced HIPK2 phosphorylation by AMPKalpha2 in vitro
Identifier Residue Sequence Organism Cell Line
SIGNOR-275487 Thr1116 AALGSTGtVAHLVAS
pmid sentence
AMPKalpha2-mediated inhibition of WIP1 phosphorylation by HIPK2|Site-directed mutagenesis of Thr112 and Ser114 in the N terminus, and Thr1107 in the C terminus markedly reduced HIPK2 phosphorylation by AMPKalpha2 in vitro
Identifier Residue Sequence Organism Cell Line
SIGNOR-275485 Thr119 HNLMRRStVSLLDTY
pmid sentence
AMPKalpha2-mediated inhibition of WIP1 phosphorylation by HIPK2|Site-directed mutagenesis of Thr112 and Ser114 in the N terminus, and Thr1107 in the C terminus markedly reduced HIPK2 phosphorylation by AMPKalpha2 in vitro
Publications: 3
+ PRKAA2up-regulates img/direct-activation.png phosphorylation TSC2 0.567
Identifier Residue Sequence Organism Cell Line
SIGNOR-149388 Ser1387 QPLSKSSsSPELQTL Homo sapiens
pmid sentence
We have observed that ampk directly phosphorylates tsc2, and the ampk-dependent phosphorylation of tsc2 is critical for the coordination between cell growth and cellular energy levels.
Publications: 1 Organism: Homo Sapiens
+ PRKAA2down-regulates img/direct_inhibition.png phosphorylation CRTC2 0.478
Identifier Residue Sequence Organism Cell Line
SIGNOR-166365 Ser171 SALNRTSsDSALHTS Homo sapiens
pmid sentence
Phosphorylation on the ser171 residue of crtc2 by ampk and ampk-related kinases, including the salt-inducible kinases (siks), is critical for determining the activity, cellular localization, and degradation of crtc2
Identifier Residue Sequence Organism Cell Line
SIGNOR-140238 Ser171 SALNRTSsDSALHTS Homo sapiens
pmid sentence
Phosphorylation on the ser171 residue of crtc2 by ampk and ampk-related kinases, including the salt-inducible kinases (siks), is critical for determining the activity, cellular localization, and degradation of crtc2
Identifier Residue Sequence Organism Cell Line
SIGNOR-142211 Ser171 SALNRTSsDSALHTS Homo sapiens
pmid sentence
Phosphorylation on the ser171 residue of crtc2 by ampk and ampk-related kinases, including the salt-inducible kinases (siks), is critical for determining the activity, cellular localization, and degradation of crtc2
Publications: 3 Organism: Homo Sapiens
+ PRKACAdown-regulates img/direct_inhibition.png phosphorylation PRKAA2 0.407
Identifier Residue Sequence Organism Cell Line
SIGNOR-161860 Ser173 DGEFLRTsCGSPNYA Homo sapiens
pmid sentence
Pka associates with and phosphorylates ampk?1 At ser-173 to impede threonine thr-172 phosphorylation and thus activation of ampk1 by lkb1 in response to lipolytic signals
Publications: 1 Organism: Homo Sapiens
+ PRKAA2up-regulates img/direct-activation.png phosphorylation IKBKB 0.258
Identifier Residue Sequence Organism Cell Line
SIGNOR-174401 Ser177 AKELDQGsLCTSFVG Homo sapiens
pmid sentence
These results demonstrate that the ikk is a direct substrate of ampk_2 and that its phosphorylation on ser177 and ser181no initiates the activation of the ampk_2 in endothelial cells which in turn phosphorylates and activates the _-subunit of the ikk. The latter also induces a higher rate of ikk auto-inactivation and thus attenuates the activation of nf_b and the expression of inflammatory genes
Identifier Residue Sequence Organism Cell Line
SIGNOR-174405 Ser181 DQGSLCTsFVGTLQY Homo sapiens
pmid sentence
These results demonstrate that the ikk is a direct substrate of ampk_2 and that its phosphorylation on ser177 and ser181no initiates the activation of the ampk_2 in endothelial cells which in turn phosphorylates and activates the _-subunit of the ikk. The latter also induces a higher rate of ikk auto-inactivation and thus attenuates the activation of nf_b and the expression of inflammatory genes
Publications: 2 Organism: Homo Sapiens
+ PRKAA2 img/unknown.png phosphorylation PAK2 0.243
Identifier Residue Sequence Organism Cell Line
SIGNOR-195110 Ser20 APPVRMSsTIFSTGG Homo sapiens
pmid sentence
Together, these results indicate that ampk phosphorylates endogenous ppp1r12c at s452 and pak2 at s20 in human cells.
Publications: 1 Organism: Homo Sapiens
+ PRKAA2down-regulates activity img/direct_inhibition.png phosphorylation ACACB 0.642
Identifier Residue Sequence Organism Cell Line
SIGNOR-250318 Ser222 PTMRPSMsGLHLVKR Homo sapiens
pmid sentence
The results suggest that the decrease in ACC activity during muscle contraction is caused by an increase in its phosphorylation, most probably due, at least in part, to activation of the alpha2 isoform of AMPK.
Identifier Residue Sequence Organism Cell Line
SIGNOR-250316 Ser222 PTMRPSMsGLHLVKR Homo sapiens
pmid sentence
ACCβ(Ser221) is a known target for AMPK in human skeletal muscle
Publications: 2 Organism: Homo Sapiens
+ PRKAA2up-regulates activity img/direct-activation.png phosphorylation PDHA1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-276840 Ser295 RYHGHSMsDPGVSYR in vitro
pmid sentence
AMPKα phosphorylates PDHA subunit on Ser295 and Ser314 to activate PDH complex
Identifier Residue Sequence Organism Cell Line
SIGNOR-276838 Ser314 IQEVRSKsDPIMLLK in vitro
pmid sentence
AMPKα phosphorylates PDHA subunit on Ser295 and Ser314 to activate PDH complex
Publications: 2 Organism: In Vitro
+ PRKAA2down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation HNF4A 0.372
Identifier Residue Sequence Organism Cell Line
SIGNOR-250322 Ser313 GKIKRLRsQVQVSLE Cricetulus griseus CHO Cell
pmid sentence
AMPK directly phosphorylates HNF4alpha and represses its transcriptional activity. AMPK-mediated phosphorylation of HNF4alpha on serine 304 had a 2-fold effect, reducing the ability of the transcription factor to form homodimers and bind DNA and increasing its degradation rate in vivo. Phosphorylation of HNF4α on Ser-304 reduces protein stability.
Publications: 1 Organism: Cricetulus Griseus
+ PRKAA2up-regulates img/direct-activation.png phosphorylation ULK1 0.491
Identifier Residue Sequence Organism Cell Line
SIGNOR-170859 Ser317 SHLASPPsLGEMQQL Homo sapiens
pmid sentence
In a screen for conserved substrates of ampk, we identified ulk1 and ulk2, mammalian orthologs of the yeast protein kinase atg1, which is required for autophagy.
Identifier Residue Sequence Organism Cell Line
SIGNOR-186633 Ser317 SHLASPPsLGEMQQL Homo sapiens
pmid sentence
In a screen for conserved substrates of ampk, we identified ulk1 and ulk2, mammalian orthologs of the yeast protein kinase atg1, which is required for autophagy.
Identifier Residue Sequence Organism Cell Line
SIGNOR-170863 Ser556 GLGCRLHsAPNLSDL Homo sapiens
pmid sentence
In a screen for conserved substrates of ampk, we identified ulk1 and ulk2, mammalian orthologs of the yeast protein kinase atg1, which is required for autophagy.
Identifier Residue Sequence Organism Cell Line
SIGNOR-186637 Ser556 GLGCRLHsAPNLSDL Homo sapiens
pmid sentence
In a screen for conserved substrates of ampk, we identified ulk1 and ulk2, mammalian orthologs of the yeast protein kinase atg1, which is required for autophagy.
Identifier Residue Sequence Organism Cell Line
SIGNOR-186641 Ser638 FDFPKTPsSQNLLAL Homo sapiens
pmid sentence
In a screen for conserved substrates of ampk, we identified ulk1 and ulk2, mammalian orthologs of the yeast protein kinase atg1, which is required for autophagy.
Identifier Residue Sequence Organism Cell Line
SIGNOR-170867 Ser638 FDFPKTPsSQNLLAL Homo sapiens
pmid sentence
In a screen for conserved substrates of ampk, we identified ulk1 and ulk2, mammalian orthologs of the yeast protein kinase atg1, which is required for autophagy.
Publications: 6 Organism: Homo Sapiens
+ PRKAA2down-regulates img/direct_inhibition.png phosphorylation VASP 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-176642 Ser322 TTLPRMKsSSSVTTS Homo sapiens
pmid sentence
Here we show that phosphorylation of vasp by ampk occurs at a novel site, serine 322, and that phosphorylation at this site alters actin filament binding. We also show that inhibition of ampk activity results in the accumulation of vasp at cell-cell adhesions and a concomitant increase in cell-cell adhesion.
Identifier Residue Sequence Organism Cell Line
SIGNOR-150462 Thr278 LARRRKAtQVGEKTP Homo sapiens
pmid sentence
Pharmacological ampk inhibitors and activators and ampk mutants revealed that the kinase specifically targets residue thr-278 but not ser-157 or ser-239. Quantitative fluorescence-activated cell sorter analysis and serum response factor transcriptional reporter assays, which quantify the cellular f-/g-actin equilibrium, indicated that ampk-mediated vasp phosphorylation impaired actin stress fiber formation and altered cell morphology.
Publications: 2 Organism: Homo Sapiens
+ PRKAA2down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation DUSP1 0.275
Identifier Residue Sequence Organism Cell Line
SIGNOR-276890 Ser334 AVLDRGTsTTTVFNF Homo sapiens HEK-293 Cell
pmid sentence
Taken together, these results imply that nicotine acts via AMPKα2 to phosphorylate MKP1 at Ser334, instigating MKP1 ubiquitination and proteasome-mediated degradation.
Publications: 1 Organism: Homo Sapiens
+ PRKAA2down-regulates img/direct_inhibition.png phosphorylation BAIAP2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-195102 Ser366 KTLPRSSsMAAGLER Homo sapiens
pmid sentence
Using this approach for ppp1r12c, baiap2, and cdc27, we found that mutation of a single serine to alanine (s452, s366, and s379 respectively) resulted in almost a complete loss of ampk phosphorylation in these proteins. Termination of irsp53 function is suggested to occur following cdc42 dissociation, kinase phosphorylation of t340 and t360, and subsequent 14-3-3 binding, which competes for sh3 partners, thus allowing filopodial retraction
Identifier Residue Sequence Organism Cell Line
SIGNOR-161810 Ser366 KTLPRSSsMAAGLER Homo sapiens
pmid sentence
Using this approach for ppp1r12c, baiap2, and cdc27, we found that mutation of a single serine to alanine (s452, s366, and s379 respectively) resulted in almost a complete loss of ampk phosphorylation in these proteins. Termination of irsp53 function is suggested to occur following cdc42 dissociation, kinase phosphorylation of t340 and t360, and subsequent 14-3-3 binding, which competes for sh3 partners, thus allowing filopodial retraction
Publications: 2 Organism: Homo Sapiens
+ PRKAA2down-regulates activity img/direct_inhibition.png phosphorylation EEF2K 0.487
Identifier Residue Sequence Organism Cell Line
SIGNOR-250319 Ser366 SPQVRTLsGSRPPLL in vitro
pmid sentence
AMPK can phosphorylate three sites in eEF2 kinase in vitro. Of these, Ser-398 appears to be more efficiently phosphorylated than either Ser-78 or Ser-366. Ser-78 and Ser-366 do not appear to be phosphorylated by AMPK within cells. Ser-366 serves to decrease the activity of eEF2 kinase
Identifier Residue Sequence Organism Cell Line
SIGNOR-250321 Ser78 SSGSPANsFHFKEAW in vitro
pmid sentence
AMPK can phosphorylate three sites in eEF2 kinase in vitro. Of these, Ser-398 appears to be more efficiently phosphorylated than either Ser-78 or Ser-366. Ser-78 and Ser-366 do not appear to be phosphorylated by AMPK within cells. Ser-366 serves to decrease the activity of eEF2 kinase
Publications: 2 Organism: In Vitro
+ PRKAA2 img/unknown.png phosphorylation CDC27 0.264
Identifier Residue Sequence Organism Cell Line
SIGNOR-195106 Ser379 NALPRRSsRLFTSDS Homo sapiens
pmid sentence
Using this approach for ppp1r12c, baiap2, and cdc27, we found that mutation of a single serine to alanine (s452, s366, and s379, respectively) resulted in an almost complete loss of ampk phosphorylation in these proteins
Publications: 1 Organism: Homo Sapiens
+ PRKAA2down-regulates img/direct_inhibition.png phosphorylation SREBF1 0.332
Identifier Residue Sequence Organism Cell Line
SIGNOR-173031 Ser396 TAVHKSKsLKDLVSA Homo sapiens
pmid sentence
Here we demonstrate that ampk interacts with and directly phosphorylates sterol regulatory element binding proteins (srebp-1c and -2). Ser372
Publications: 1 Organism: Homo Sapiens
+ PRKAA2up-regulates activity img/direct-activation.png phosphorylation EEF2K 0.487
Identifier Residue Sequence Organism Cell Line
SIGNOR-250158 Ser398 DSLPSSPsSATPHSQ in vitro
pmid sentence
Stimulation of the AMP-activated Protein Kinase Leads to Activation of Eukaryotic Elongation Factor 2 Kinase and to Its Phosphorylation at a Novel Site, Serine 398. phosphorylation of eEF2 kinase at Ser-398 leads to an increase in its activity.
Publications: 1 Organism: In Vitro
+ PRKAA2down-regulates img/direct_inhibition.png phosphorylation PPP1R12C 0.261
Identifier Residue Sequence Organism Cell Line
SIGNOR-195148 Ser452 AGLQRSAsSSWLEGT Homo sapiens
pmid sentence
Ampk-induced phosphorylation is necessary for ppp1r12c interaction with 14-3-3 and phosphorylation of myosin regulatory light chain. Both ampk activity and ppp1r12c phosphorylation are increased in mitotic cells and are important for mitosis completion. The interaction between ppp1r12c and 14-3-3_ may inactivate the ppp1r12c-containing phosphatase complex in vivo.
Publications: 1 Organism: Homo Sapiens
+ PRKAA2up-regulates activity img/direct-activation.png phosphorylation PFKFB2 0.434
Identifier Residue Sequence Organism Cell Line
SIGNOR-250323 Ser466 PVRMRRNsFTPLSSS Homo sapiens HEK-293 Cell
pmid sentence
AMPK phosphorylates and activates heart PFK-2 in vitro and in intact cells.  activation of PFK-2 was due to the phosphorylation of Ser466
Publications: 1 Organism: Homo Sapiens
+ PRKAA2up-regulates img/direct-activation.png phosphorylation PLD1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-164293 Ser505 GSVKRVTsGPSLGSL Homo sapiens
pmid sentence
Ampk-wild type (wt) stimulates pld activity, while ampk-dominant negative (dn) inhibits it. Ampk regulates pld1 activity through phosphorylation of the ser-505 and this phosphorylation is increased by the presence of amp.
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
+ PRKAA2down-regulates img/direct_inhibition.png phosphorylation RPTOR 0.686
Identifier Residue Sequence Organism Cell Line
SIGNOR-263045 Ser722 PRLRSVSsYGNIRAV Mus musculus
pmid sentence
These results suggest that AMPK activation can induce phosphorylation of both serine 722 and serine 792.|Raptor phosphorylation is required for inhibition of mTORC1 by AMPK
Publications: 1 Organism: Mus Musculus
+ PRKAA2down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation PROX1 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-277608 Ser79 KLLKRANsYEDAMMP Homo sapiens HEK-293T Cell
pmid sentence
Furthermore, the Ser79 phosphorylation of PROX1 by AMPK enhances the recruitment of CUL4-DDB1 ubiquitin ligase to promote PROX1 degradation.
Publications: 1 Organism: Homo Sapiens
+ PRKAA2down-regulates activity img/direct_inhibition.png phosphorylation RPTOR 0.686
Identifier Residue Sequence Organism Cell Line
SIGNOR-163463 Ser792 LTQSAPAsPTNKGVH Mus musculus
pmid sentence
These results suggest that AMPK activation can induce phosphorylation of both serine 722 and serine 792.|Raptor phosphorylation is required for inhibition of mTORC1 by AMPK
Publications: 1 Organism: Mus Musculus
+ PRKAA2down-regulates img/direct_inhibition.png phosphorylation ACACA 0.69
Identifier Residue Sequence Organism Cell Line
SIGNOR-87583 Ser80 LHIRSSMsGLHLVKQ Homo sapiens
pmid sentence
Significant negative linear correlations between phospho-acc and acc activity were observed in all models (p < 0.01). The decline in acc activity was related to the decrease in pcr and the rise in amp. A relationship between phospho-ampk (threonine 172) and activity of ampk immunoprecipitated with anti-alpha(2) subunit antibody preparation was also observed.
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle
+ PRKAA2down-regulates activity img/direct_inhibition.png phosphorylation HAS2 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-276299 Thr110 LQSVKRLtYPGIKVV Chlorocebus aethiops COS-7 Cell
pmid sentence
We found that AMPK phosphorylated Thr-110 of human HAS2, which inhibits its enzymatic activity.
Publications: 1 Organism: Chlorocebus Aethiops
+ ATMup-regulates activity img/direct-activation.png phosphorylation PRKAA2 0.266
Identifier Residue Sequence Organism Cell Line
SIGNOR-275488 Thr172 SDGEFLRtSCGSPNY
pmid sentence
ATM phosphorylates AMPKalpha2 to induce inhibitory phosphorylation of HIPK2|
Publications: 1
+ CAMKK2up-regulates img/direct-activation.png phosphorylation PRKAA2 0.611
Identifier Residue Sequence Organism Cell Line
SIGNOR-161929 Thr172 SDGEFLRtSCGSPNY Homo sapiens HeLa Cell
pmid sentence
These data indicate that the camkks function in intact cells as ampkks, predicting wider roles for these kinases in regulating ampk activity in vivo.
Identifier Residue Sequence Organism Cell Line
SIGNOR-138364 Thr172 SDGEFLRtSCGSPNY Homo sapiens HeLa Cell
pmid sentence
These data indicate that the camkks function in intact cells as ampkks, predicting wider roles for these kinases in regulating ampk activity in vivo.
Publications: 2 Organism: Homo Sapiens
+ STK11up-regulates img/direct-activation.png phosphorylation PRKAA2 0.617
Identifier Residue Sequence Organism Cell Line
SIGNOR-119179 Thr172 SDGEFLRtSCGSPNY Homo sapiens
pmid sentence
We demonstrated that lkb1 phosphorylates ampk on the activation loop threonine (thr172) within the catalytic subunit and activates ampk in vitro. Here, we have investigated whether lkb1 corresponds to the major ampkk activity present in cell extracts. Ampkk purified from rat liver corresponds to lkb1, and blocking lkb1 activity in cells abolishes ampk activation in response to different stimuli
Identifier Residue Sequence Organism Cell Line
SIGNOR-122725 Thr172 SDGEFLRtSCGSPNY Homo sapiens
pmid sentence
We demonstrated that lkb1 phosphorylates ampk on the activation loop threonine (thr172) within the catalytic subunit and activates ampk in vitro. Here, we have investigated whether lkb1 corresponds to the major ampkk activity present in cell extracts. Ampkk purified from rat liver corresponds to lkb1, and blocking lkb1 activity in cells abolishes ampk activation in response to different stimuli
Publications: 2 Organism: Homo Sapiens
+ SRCdown-regulates activity img/direct_inhibition.png phosphorylation PRKAA2 0.259
Identifier Residue Sequence Organism Cell Line
SIGNOR-277573 Tyr179 TSCGSPNyAAPEVIS Homo sapiens HEK-293T Cell
pmid sentence
We show here that Src signaling leads to direct phosphorylation of the AMPK-α subunit on a novel site, tyrosine 179, resulting in suppression of AMPK-T172 phosphorylation and autophagy upon integrin-mediated cell adhesion.
Publications: 1 Organism: Homo Sapiens
+ FYNdown-regulates activity img/direct_inhibition.png phosphorylation PRKAA2 0.259
Identifier Residue Sequence Organism Cell Line
SIGNOR-277279 Tyr436 EWKVVNAyHLRVRRK Mus musculus NIH-3T3 Cell
pmid sentence
Here we identified that Fyn phosphorylates the α subunit of AMPK on Y436 and inhibits AMPK enzymatic activity without altering the assembly state of the AMPK heterotrimeric complex. 
Publications: 1 Organism: Mus Musculus
+ ULK1down-regulates img/direct_inhibition.png phosphorylation PRKAA2 0.491
Identifier Residue Sequence Organism Cell Line
SIGNOR-173050 Homo sapiens
pmid sentence
Here we report that ulk1/2 in turn phosphorylates all three subunits of ampk and thereby negatively regulates its activity. Thus, we propose that ulk1 is not only involved in the induction of autophagy, but also in terminating signaling events that trigger autophagy. In our model, phosphorylation of ampk by ulk1 represents a negative feedback circuit.
Publications: 1 Organism: Homo Sapiens
+ AICA-Ribotideup-regulates img/direct-activation.png chemical activation PRKAA2 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-186055 Homo sapiens Myoblast
pmid sentence
Aicar-induced ampk phosphorylation inhibits cell cycle transition, reducing differentiation of myoblasts into myotubes, through pgc-1alpha-foxo3a-p21.
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle, Skeletal Muscle, Myotube
+ ULK2down-regulates img/direct_inhibition.png phosphorylation PRKAA2 0.307
Identifier Residue Sequence Organism Cell Line
SIGNOR-173089 Homo sapiens
pmid sentence
We could prove that ulk1-mediated phosphorylation of ampk reduced its level of phosphorylation at t172 of the _-subunit and hence interferes with its catalytic activity. I
Publications: 1 Organism: Homo Sapiens
+ PRKAG1up-regulates img/direct-activation.png binding PRKAA2 0.895
Identifier Residue Sequence Organism Cell Line
SIGNOR-139173 Homo sapiens
pmid sentence
Gamma non-catalytic subunit mediates binding to amp, adp and atp, leading to activate or inhibit ampk: amp-binding results in allosteric activation of alpha catalytic subunit (prkaa1 or prkaa2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits.
Publications: 1 Organism: Homo Sapiens
+ PRKAA2up-regulates img/direct-activation.png phosphorylation IKK-complex 0.258
Identifier Residue Sequence Organism Cell Line
SIGNOR-217457 Homo sapiens Monocyte
pmid sentence
These results demonstrate that the ikk is a direct substrate of ampk_2 and that its phosphorylation on ser177 and ser181no initiates the activation of the ampk_2 in endothelial cells which in turn phosphorylates and activates the _-subunit of the ikk. The latter also induces a higher rate of ikk auto-inactivation and thus attenuates the activation of nf_b and the expression of inflammatory genes
Publications: 1 Organism: Homo Sapiens
+ PRKAA2form complex img/form-complex.png binding AMPK 0.826
Identifier Residue Sequence Organism Cell Line
SIGNOR-139161 Homo sapiens
pmid sentence
Gamma non-catalytic subunit mediates binding to amp, adp and atp, leading to activate or inhibit ampk: amp-binding results in allosteric activation of alpha catalytic subunit (prkaa1 or prkaa2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits.
Publications: 1 Organism: Homo Sapiens
+ metforminup-regulates img/indirect-activation.png PRKAA2 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-111034 Homo sapiens
pmid sentence
Here we report that metformin activates ampk in hepatocytes.
Publications: 1 Organism: Homo Sapiens
+ Serumdown-regulates img/indirect_inhibition.png PRKAA2 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-186644 Homo sapiens
pmid sentence
Ampk is activated under conditions of low energy charge and typically inhibits anabolic reactions and promotes catabolism
Publications: 1 Organism: Homo Sapiens
+ PRKAA2up-regulates img/direct-activation.png phosphorylation INSR 0.376
Identifier Residue Sequence Organism Cell Line
SIGNOR-195324 Homo sapiens
pmid sentence
Ampk phosphorylates and activates theinsulinreceptor, providing a direct link between ampk and theinsulin pathway.
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
+ PRKAA2up-regulates img/direct-activation.png phosphorylation TSC1 0.539
Identifier Residue Sequence Organism Cell Line
SIGNOR-119541 Homo sapiens
pmid sentence
Under energy starvation conditions, the amp-activated protein kinase (ampk) phosphorylates tsc2 and enhances its activity.
Publications: 1 Organism: Homo Sapiens
+ PRKAA2up-regulates img/direct-activation.png phosphorylation Gbeta 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-166905 Homo sapiens
pmid sentence
Ampk recruitment and h2b ser36 phosphorylation colocalized within genes activated by ampk-dependent pathways, both in promoters and in transcribed regions.
Publications: 1 Organism: Homo Sapiens
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