Relation Results

Summary

Name HOXD3
Full Name Homeobox protein Hox-D3
Synonyms Homeobox protein Hox-4A | HOX1D, HOX4A
Primary ID P31249
Links - -
Type protein
Relations 3
Function Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on t ...
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Type: Score: Layout: SPV 
0.2520.2520.3HOXD3A5/b1 integrinITGA5HMGB1

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Relations
Regulator
Mechanism
target
score ℹ
+ HOXD3up-regulates quantity by expression img/direct-activation.png transcriptional regulation A5/b1 integrin 0.252
Identifier Residue Sequence Organism Cell Line
SIGNOR-261650 Homo sapiens HMEC-1 Cell
pmid sentence
The homeobox transcription factor Hox D3 promotes integrin alpha5beta1 expression and function during angiogenesis.
Publications: 1 Organism: Homo Sapiens
+ HOXD3up-regulates quantity by expression img/direct-activation.png transcriptional regulation ITGA5 0.252
Identifier Residue Sequence Organism Cell Line
SIGNOR-261649 Homo sapiens
pmid sentence
The homeobox transcription factor Hox D3 promotes integrin alpha5beta1 expression and function during angiogenesis.
Publications: 1 Organism: Homo Sapiens
+ HMGB1up-regulates activity img/direct-activation.png binding HOXD3 0.3
Identifier Residue Sequence Organism Cell Line
SIGNOR-219980 in vitro
pmid sentence
We show that HMG1 interacts with proteins encoded by the HOX gene family by establishing protein-protein contacts between the HMG box domains and the HOX homeodomain. The functional role of these interactions was studied using the transcriptional activity of the human HOXD9 protein as a model. HMG1 enhances, in a dose-dependent fashion, the sequence-specific DNA binding activity in vitro, and the transcriptional activation in a co-transfection assay in vivo, of the HOXD9 protein.
Publications: 1 Organism: In Vitro
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