3.0
Summary
| Name |  ATICView Modifications |
| Full Name | Bifunctional purine biosynthesis protein ATIC |
| Synonyms | PUR9_HUMAN | PURH |
| Primary ID | P31939 |
| Links |  -  -  |
| Type | protein |
| Relations | 7 |
| Pathways | Nucleotide Biosynthesis |
| Inhibitors | pemetrexed disodium |
| Function | Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis (PubMed:11948179, PubMed:14756554). Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR) (PubMed:9378707, PubMed:11948179, PubMed:10985775). Can use both 10-formyldihydrofolate and 10-formyltetrahydrofolate as the formyl donor in this reaction (PubMed:10985775). Also catalyzes the cyclization of FAICAR to IMP (PubMed:11948179, PubMed:14756554). Is able to convert thio-AICAR to 6-mercaptopurine ribonucleotide, an inhibitor of purine biosynthesis used in the treatment of human leukemias (PubMed:10985775). Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization (PubMed:25687571). |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | VASP | up-regulates activity 
phosphorylation
|
ATIC | 0.354 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ALK | up-regulates activity
phosphorylation
|
ATIC | 0.39 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ATIC | up-regulates quantity
chemical modification
|
(6S)-5,6,7,8-tetrahydrofolate(2-) | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Nucleotide Biosynthesis | |||
| + | pemetrexed disodium | down-regulates activity 
chemical inhibition
|
ATIC | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | ATIC | down-regulates quantity
chemical modification
|
10-formyltetrahydrofolate(2-) | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Nucleotide Biosynthesis | |||
| + | ATIC | up-regulates quantity
chemical modification
|
5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide(2-) | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Nucleotide Biosynthesis | |||
| + | ATIC | up-regulates quantity
chemical modification
|
IMP | 0.8 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Nucleotide Biosynthesis | |||