Summary

Name APOBEC3A
Full Name DNA dC->dU-editing enzyme APOBEC-3A
Synonyms A3A, Phorbolin-1 |
Primary ID P31941
Links - -
Type protein
Relations 2
Function DNA deaminase (cytidine deaminase) with restriction activity against viruses, foreign DNA and mobility of retrotransposons. Exhibits antiviral activity against adeno-associated virus (AAV) and human T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons. Selectively targets single-stranded DNA and can deaminate both methylcytosine and cytosine in foreign DNA. Can induce somatic hypermutation in the nuclear and mitochondrial DNA. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation.

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Relations

Regulator Mechanism target score
+ up-regulates img/indirect-activation.png Clearance_of_foreign intracellular_DNA 0.7
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination APOBEC3A 0.255
Publications: 1 Organism: Homo Sapiens