| + |
GRK4 | down-regulates activity 
phosphorylation
|
BDKRB2 |
0.292 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-247902 |
Ser366 |
EPIQMENsMGTLRTS |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 11517230 |
...expression of GRK4 drastically increased the basal level of32P incorporation into B2R.[]a clustered phosphorylation around Ser(346) is necessary for desensitization of the B2 receptor-induced phospholipase C activation. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-251193 |
Ser373 |
SMGTLRTsISVERQI |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 11517230 |
Expression of GRK4α drastically increased the basal level of32P incorporation into B2R. GRK4α elevated the basal phosphorylation of Ser339 and Ser346/Ser348. phosphorylation of specific residues was correlated with the initiation of receptor internalization and the regulation of its desensitization. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-249674 |
Ser375 |
GTLRTSIsVERQIHK |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 11517230 |
...expression of GRK4 drastically increased the basal level of32P incorporation into B2R.[]a clustered phosphorylation around Ser(346) is necessary for desensitization of the B2 receptor-induced phospholipase C activation. |
|
| Publications: |
3 |
Organism: |
Homo Sapiens |
3.0
GRK4
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